PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1

Nucleic Acids Research

Volumn 42, Issue 12, 2014, Pages 7762-7775

  Langelier, Marie France ^a   Riccio, Amanda A ^a   Pascal, John M ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; DNA; GLYCINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 2; PROTEIN PARP 3; TRYPTOPHAN; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DNA BINDING; DNA FLANKING REGION; DNA REPAIR; DNA STRAND BREAKAGE; DNA STRUCTURE; GENE ACTIVATION; HUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRYPTOPHAN GLYCINE ARGININE DOMAIN;

ALLOSTERIC REGULATION; CELL CYCLE PROTEINS; DNA BREAKS; ENZYME ACTIVATION; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN STRUCTURE, TERTIARY;

EID: 84903977632     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gku474     Document Type: Article

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