Crystal structures of poly(ADP-ribose) polymerase-1 (PARP-1) zinc fingers bound to DNA: Structural and functional insights into DNA-dependent PARP-1 activity

Journal of Biological Chemistry

Volumn 286, Issue 12, 2011, Pages 10690-10701

  Langelier, Marie France ^a   Planck, Jamie L ^a   Roy, Swati ^a   Pascal, John M ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADP-RIBOSE; BINDING AFFINITIES; BIOLOGICAL ANALYSIS; DNA COMPLEX; DNA INTERACTION; DNA REPAIR; DNA STRUCTURE; HYDROPHOBIC INTERACTIONS; IN-VITRO; NUCLEOTIDE BASIS; PHOSPHODIESTERS; POLY(ADP-RIBOSE)-POLYMERASE 1 (PARP-1); STRAND BREAKS; STRUCTURAL BASIS; STRUCTURAL DIFFERENCES; ZINC FINGER; ZINC FINGER DOMAINS;

ACTIVATION ANALYSIS; BINDING ENERGY; COMPLEXATION; CRYSTAL STRUCTURE; FUNCTIONAL POLYMERS; HYDROPHOBICITY; NUCLEIC ACIDS; NUCLEOTIDES; RHENIUM COMPOUNDS; STRUCTURAL ANALYSIS; ZINC;

DNA;

DOUBLE STRANDED DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN ZN1; PROTEIN ZN2; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DNA STRUCTURE; HOMOLOGOUS RECOMBINATION; HYDROPHOBICITY; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; SEQUENCE ALIGNMENT; STRUCTURE ANALYSIS;

ANIMALS; CELL LINE; DNA; DNA BREAKS, DOUBLE-STRANDED; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; MICE, KNOCKOUT; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; ZINC FINGERS;

EID: 79953176276     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.202507     Document Type: Article

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