Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation

Human Molecular Genetics

Volumn 24, Issue 24, 2015, Pages 6886-6898

  Coyne, Alyssa N ^a,b   Yamada, Shizuka B ^a   Siddegowda, Bhavani Bagevalu ^a   Estes, Patricia S ^a   Zaepfel, Benjamin L ^a   Johannesmeyer, Jeffrey S ^a   Lockwood, Donovan B ^a,b   Pham, Linh T ^a   Hart, Michael P ^d   Cassel, Joel A ^e   Freibaum, Brian ^f   Boehringer, Ashley V ^a,b,c   Paul Taylor, J ^f   Reitz, Allen B ^e   Gitler, Aaron D ^d   Zarnescu, Daniela C ^a,b,c  

^a The University of Arizona   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Pennsylvania Biotechnology Center   (United States)

^f ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; FRAGILE X MENTAL RETARDATION PROTEIN; MESSENGER RNA; RNA; TAR DNA BINDING PROTEIN; DNA BINDING PROTEIN; DROSOPHILA PROTEIN; FUTSCH PROTEIN, DROSOPHILA; MICROTUBULE ASSOCIATED PROTEIN; NEUROTOXIN; RNA BINDING PROTEIN; TDP-43 PROTEIN, HUMAN;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FRACTIONATION; CELL GRANULE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA MODIFICATION; DROSOPHILA; FEMALE; GENE EXPRESSION PROFILING; GENE INTERACTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIFESPAN; LOCOMOTION; MOLECULAR BIOLOGY; MOTONEURON; NEUROEPITHELIUM; NEUROMUSCULAR SYNAPSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PHENOTYPIC VARIATION; POLYSOME; PRIORITY JOURNAL; TOXICITY TESTING; TRANSLATION INITIATION; ANIMAL; DISEASE MODEL; DROSOPHILA MELANOGASTER; GENE SILENCING; GENE TRANSLOCATION; GENETICS; METABOLISM; NERVE CELL; NEUROMUSCULAR JUNCTION; PHENOTYPE; SOLUBILITY;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; NEUROMUSCULAR JUNCTION; NEURONS; NEUROTOXINS; PHENOTYPE; RNA, MESSENGER; RNA-BINDING PROTEINS; SOLUBILITY; TRANSLOCATION, GENETIC;

EID: 84952862498     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv389     Document Type: Article

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