C9RAN translation: A potential therapeutic target for the treatment of amyotrophic lateral sclerosis and frontotemporal dementia

Expert Opinion on Therapeutic Targets

Volumn 17, Issue 9, 2013, Pages 991-995

  Gendron, Tania F ^a   Cosio, Danielle M ^a   Petrucelli, Leonard ^a  

^a MAYO CLINIC   (United States)

Author keywords

Amyotrophic lateral sclerosis; C9ORF72; Expanded hexanucleotide repeat; Foci; Frontotemporal dementia; Neurodegeneration; Repeat associated non ATG translation; RNA

Indexed keywords

GUANINE QUADRUPLEX; NUCLEAR RNA; RNA BINDING PROTEIN; SMALL INTERFERING RNA;

ALLELE; AMYOTROPHIC LATERAL SCLEROSIS; CYTOPLASM; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; HUMAN; MOLECULARLY TARGETED THERAPY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN SECONDARY STRUCTURE; REVIEW; RNA BINDING; RNA SPLICING; RNA TRANSLATION;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CHROMOSOMES, HUMAN, PAIR 9; DNA REPEAT EXPANSION; FRONTOTEMPORAL DEMENTIA; HUMANS; PROTEIN BIOSYNTHESIS; PROTEINS;

EID: 84882687005     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2013.818659     Document Type: Review

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