Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function

Biochimie

Volumn 94, Issue 9, 2012, Pages 1974-1981

  Cassel, Joel A ^a   McDonnell, Mark E ^b   Velvadapu, Venkata ^b   Andrianov, Vyacheslav ^a   Reitz, Allen B ^a  

^a Pennsylvania Biotechnology Center   (United States)

^b Fox Chase Chemical Diversity Center Inc   (United States)

Author keywords

Caspase activation; Mixed inhibition; TDP 43

Indexed keywords

4 AMINOQUINOLINE DERIVATIVE; CASPASE 3; CASPASE 7; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OLIGONUCLEOTIDE; TAR DNA BINDING PROTEIN;

ARTICLE; CELL FUNCTION; ENZYME ACTIVITY; GLIOMA; HUMAN; HUMAN CELL; INCUBATION TIME; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN FUNCTION; STRUCTURE ANALYSIS;

AMINOQUINOLINES; BIOTINYLATION; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HIGH-THROUGHPUT SCREENING ASSAYS; HISTONE DEACETYLASES; HUMANS; POLY(ADP-RIBOSE) POLYMERASES; PROTEOLYSIS; RNA, SMALL INTERFERING; UBIQUITIN-ACTIVATING ENZYMES;

EID: 84864279352     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.05.020     Document Type: Article

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