Hyperglycemia stimulates p62/PKCζ interaction, which mediates NF-κB activation, increased Nox4 expression, and inflammatory cytokine activation in vascular smooth muscle

FASEB Journal

Volumn 29, Issue 12, 2015, Pages 4772-4782

  Xi, Gang ^a   Shen, Xinchun ^b   Wai, Christine ^a   Vilas, Caroline K ^a   Clemmons, David R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NANJING UNIVERSITY OF FINANCE AND ECONOMICS   (China)

Author keywords

Diabetes; IGF I; P65 rel; PDK1; TNF

Indexed keywords

GSK 227434; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C ZETA; PROTEIN P62; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SOMATOMEDIN C; UNCLASSIFIED DRUG; AUTACOID; CYTOKINE; HEAT SHOCK PROTEIN; NOX4 PROTEIN, MOUSE; PROTEIN KINASE C; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SEQUESTOSOME 1; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETES MELLITUS; HYPERGLYCEMIA; METABOLIC STRESS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION; PIG; VASCULAR SMOOTH MUSCLE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELLS, CULTURED; CYTOKINES; ENZYME ACTIVATION; HEAT-SHOCK PROTEINS; HYPERGLYCEMIA; INFLAMMATION MEDIATORS; MICE; MICE, INBRED C57BL; MUSCLE, SMOOTH, VASCULAR; NADPH OXIDASE; NF-KAPPA B; PHOSPHORYLATION; PROTEIN KINASE C; SEQUESTOSOME-1 PROTEIN; SWINE;

EID: 84952707793     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.15-275453     Document Type: Article

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