Thioredoxin-interacting protein mediates dysfunction of tubular autophagy in diabetic kidneys through inhibiting autophagic flux

Laboratory Investigation

Volumn 94, Issue 3, 2014, Pages 309-320

  Huang, Chunling ^a,b   Lin, Mike Z ^a   Cheng, Delfine ^c   Braet, Filip ^c   Pollock, Carol A ^a   Chen, Xin Ming ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b XIAMEN UNIVERSITY   (China)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

autophagy; autophagy flux; diabetic nephropathy; renal proximal tubular cells; thioredoxin interacting protein

Indexed keywords

BAFILOMYCIN A1; GLUCOSE; PROTEIN P62; SMALL INTERFERING RNA; THIOREDOXIN INTERACTING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL VACUOLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPERGLYCEMIA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; LYSOSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; AUTOPHAGY; CARRIER PROTEINS; CELL LINE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; GENE KNOCKDOWN TECHNIQUES; HUMANS; KIDNEY TUBULES, PROXIMAL; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; OXIDATIVE STRESS; PHAGOSOMES; RNA, MESSENGER; RNA-BINDING PROTEINS; THIOREDOXINS; TRANSCRIPTION FACTORS;

EID: 84896807067     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2014.2     Document Type: Article

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