Recruitment of Nox4 to a plasma membrane scaffold is required for localized reactive oxygen species generation and sustained Src activation in response to insulin-like growth factor-I

Journal of Biological Chemistry

Volumn 288, Issue 22, 2013, Pages 15641-15653

  Xi, Gang ^a   Shen, Xin Chun ^a   Wai, Christine ^a   Clemmons, David R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ACTIONS; CLOSE PROXIMITY; INSULIN-LIKE GROWTH FACTOR-I; OVER-EXPRESSION; REACTIVE OXYGEN SPECIES; ROS GENERATIONS; SCAFFOLD PROTEIN; SIGNALING COMPLEX;

AMINO ACIDS; CELL MEMBRANES; CELL PROLIFERATION; CELL SIGNALING; OXIDATION; SIGNAL TRANSDUCTION;

SCAFFOLDS (BIOLOGY);

FOCAL ADHESION KINASE 2; GLUCOSE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; HYDROGEN PEROXIDE; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SOMATOMEDIN C; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CELL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVITY; GENE OVEREXPRESSION; HYPERGLYCEMIA; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ATHEROSCLEROSIS; DIABETES; INSULIN-LIKE GROWTH FACTOR (IGF); NADPH OXIDASE; REACTIVE OXYGEN SPECIES (ROS); SIGNAL TRANSDUCTION; SRC;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENS, DIFFERENTIATION; AORTA; CELL MEMBRANE STRUCTURES; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; ENZYME ACTIVATION; GRB2 ADAPTOR PROTEIN; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MICE; MUTATION, MISSENSE; NADPH OXIDASE; OXIDATION-REDUCTION; PROTEIN BINDING; REACTIVE OXYGEN SPECIES; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; SRC-FAMILY KINASES; SWINE;

MUS;

EID: 84878408065     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.456046     Document Type: Article

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