Anthocyanin extracted from black Soybean seed coats prevents autoimmune arthritis by suppressing the development of Th17 cells and synthesis of proinflammatory cytokines by such cells, via inhibition of NF-ΚB

PLoS ONE

Volumn 10, Issue 11, 2015, Pages

  Min, Hong Ki ^a,b   Kim, Sung Min ^a   Baek, Seung Ye ^a   Woo, Jung Won ^c   Park, Jin Sil ^a   Cho, Mi La ^a   Lee, Jennifer ^a,b   Kwok, Seung Ki ^a,b   Kim, Sae Woong ^b   Park, Sung Hwan ^a,b  

^a The Catholic University of Korea   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c POSTECH Biotech Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ANTHOCYANIN; CD4 ANTIGEN; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 17; MESSENGER RNA; STAT3 PROTEIN; COLLAGEN; CYTOKINE; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARTHRITIC ACTIVITY; ARTHRITIS; ARTICLE; AUTOIMMUNE ARTHRITIS; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG ACTIVITY; DRUG EFFECT; GENE EXPRESSION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MALE; MOUSE; NONHUMAN; OSTEOCLAST; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; PLANT SEED; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SOYBEAN; SPLEEN; TH17 CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTHRITIS, EXPERIMENTAL; AUTOIMMUNE DISEASES; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL DIFFERENTIATION; CHEMICALLY INDUCED; CHEMISTRY; CYTOLOGY; DBA MOUSE; DRUG EFFECTS; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; METABOLISM; MONONUCLEAR CELL; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANTHOCYANINS; ARTHRITIS, EXPERIMENTAL; AUTOIMMUNE DISEASES; BLOTTING, WESTERN; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; COLLAGEN; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; IMMUNOENZYME TECHNIQUES; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MICE, INBRED DBA; NF-KAPPA B; OSTEOCLASTS; PLANT EXTRACTS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEEDS; SIGNAL TRANSDUCTION; SOYBEANS; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 84952685352     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0138201     Document Type: Article

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