Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 7, 2008, Pages 2311-2315

  Hasvold, Lisa A ^a   Wang, Le ^a   Przytulinska, Magdalena ^a   Xiao, Zhan ^a   Chen, Zehan ^a   Gu, Wen Zhen ^a   Merta, Philip J ^a   Xue, John ^a   Kovar, Peter ^a   Zhang, Haiying ^a   Park, Chang ^a   Sowin, Thomas J ^a   Rosenberg, Saul H ^a   Lin, Nan Horng ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Chk1

Indexed keywords

BENZODIAZEPINE DERIVATIVE; CHECKPOINT KINASE 1; ENZYME INHIBITOR;

ARTICLE; DEPROTECTION REACTION; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME SPECIFICITY; ESTERIFICATION; HECK REACTION; NITRATION; REDUCTION; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION;

ANTINEOPLASTIC AGENTS; BENZODIAZEPINONES; CELL LINE, TUMOR; DRUG DESIGN; ENZYME INHIBITORS; HELA CELLS; HUMANS; MODELS, CHEMICAL; PROTEIN BINDING; PROTEIN KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN ECHOVIRUS 1;

EID: 41349120782     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.02.080     Document Type: Article

References (8)

1. Walworth N.C. Curr. Opin. Cell Biol. 12 (2000) 697-704
2. Powell S.N., DeFrank J.S., Connell P., Eogan M., Preffer F., Dombkowski D., Tang W., and Friend S. Cancer Res. 55 (1995) 1643
3. Kawabe T. Mol. Cancer Ther. 3 (2004) 513
4. Zhou B.B., and Elledge S.J. Nature 408 (2000) 433
5. Li Q., and Zhu G.-D. Curr. Top. Med. Chem. 2 (2002) 939
6. Wang L., Sullivan G.M., Hexamer L.A., Hasvold L.A., Thalji R., Przytulinska M., Tao Z.F., Li G., Chen Z., Xiao Z., Gu W.Z., Xue J., Bui M.H., Merta P., Kovar P., Bouska J.J., Zhang H., Park C., Stewart K., Sham H.L., Sowin T.J., Rosenberg S.H., and Lin N.H. J. Med. Chem. 50 17 (2007) 4162
7. Tong Y., Claiborne A., Stewart K.D., Park C., Kovar P., Chen Z., Credo R.B., Gu W.-Z., Gwaltney II S.L., Judge R.A., Zhang H., Rosenberg S.H., Sham H.L., Sowin T.J., and Lin N.-H. Bioorg. Med. Chem. 15 (2007) 2759
8. Xiao Z., Chen Z., Gunasekera A.H., Sowin T.J., Rosenberg S.H., Fesik S., and Zhang H. J. Biol. Chem. 278 24 (2003) 21767