In vitro cytotoxicity perspective of diazepinomicin (ECO-4601) on human hepatoma cell line (HEPG2)

Biomedicine and Aging Pathology

Volumn 4, Issue 1, 2014, Pages 65-70

  Rambabu, Vinayagam ^a   Vijayakumar, Subramaniyan ^a  

^a A V V M SRI PUSHPAM COLLEGE   (India)

Author keywords

Apoptosis; Diazepinomicin; Heptocellular carcinoma; Liver cancer; Secondary metabolite

Indexed keywords

DIAZEPINOMICIN; DNA FRAGMENT; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; TRYPAN BLUE;

AGAR GEL ELECTROPHORESIS; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; DRUG CYTOTOXICITY; FLUORESCENCE MICROSCOPY; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROMONOSPORA; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; WESTERN BLOTTING;

EID: 84896700370     PISSN: 22105220     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomag.2013.10.004     Document Type: Article

References (36)

1. F.X. Bosch, J. Ribes, M. Diaz, and R. Cleries Primary liver cancer: worldwide incidence and trends Gastroenterology 127 5 Suppl 1 2004 S5 S16
2. B.K. Edwards, E. Ward, B.A. Kohler, C. Eheman, A.G. Zauber, and R.N. Anderson et al. Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates Cancer 116 3 2010 544 573
3. D. Motola-Kuba, D. Zamora-Valdes, M. Uribe, and N. Mendez-Sanchez Hepatocellular carcinoma. An overview Ann Hepatol 5 2006 16 24
4. K.A. McGlynn, and W.T. London Epidemiology and natural history of hepatocellular carcinoma Best Pract Res Clin Gastroenterol 19 2005 3 23
5. P. Srivatanakul, H. Sriplung, and S. Deerasamee Epidemiology of liver cancer: an overview Asian Pac J Cancer Prev 5 2004 118 125
6. E.K. Teo, and K.M. Fock Hepatocellular carcinoma: an Asian perspective Dig Dis 19 2001 263 268
7. J.M. Clark The epidemiology of nonalcoholic fatty liver disease in adults J Clin Gastroenterol 40 2006 S5 S10
8. Y. Tanaka, K. Hanada, and M. Mizokami A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence will increase in the next two decades Proc Natl Acad Sci U S A 99 2002 15584 15589
9. F.T. Bosman, F. Carneiro, R.H. Hruban, and N.D. Theise WHO Classification of Tumours of the Digestive System vol. 3 2010 IARC Press Lyon 417
10. G. Cragg, D. Newman, and K. Snader Natural products in drug discovery and development J Nat Prod 60 1997 52 60
11. P.R. Jensen, P.G. Williams, D.C. Oh, L. Zeigler, and W. Fenical Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora Appl Environ Microbiol 73 4 2007 1146 1152
12. J.J.W. Blunt, B.R. Copp, M.H. Munro, P.T. Northcote, and M.R. Prinsep Marine natural products Nat Prod Rep 27 2 2010 165 237
13. D.W. Udwary, L. Zeigler, R.N. Asolkar, V. Singan, A. Lapidus, and W. Fenical et al. Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica Proc Natl Acad Sci U S A 104 25 2007 10376 10381
14. D.J. Newman, G.M. Cragg, and K.M. Snader Natural products as source of new drugs over the period J Nat Prod 66 7 2003 1022 1037
15. C. Méndez, and J.A. Salas Altering the glycosylation pattern of bioactive compounds Trends Biotechnol 19 11 2001 449 456
16. R.D. Charan, G. Schlingmann, J. Janso, V. Bernan, X. Feng, and G.T. Carter Diazepinomicin, a new antimicrobial alkaloid from marine Micromonospora sp J Nat Prod 67 2004 1431 1433
17. U.R. Abdelmohsen, M. Szesny, E.M. Othman, T. Schirmeister, S. Grond, and H. Stopper et al. Antioxidant and anti-protease activities of diazepinomicin from the sponge-associated Micromonospora strain RV115 Mar Drugs 10 10 2012 2208 2221
18. Q. Chen, PengW, and A. Xu Apoptosis of a human non-small cell lung cancer (NSCLC) cell line, PLA-801, induced by acutiaporberine, a novel bisalkaloid derived from Thalictrum acutifolium (Hand-Mazz) Bovin Biochem Pharmacol 63 2001 1389 1396
19. M.C. Kew Epidemiology of hepatocellular carcinoma Toxicology 181-182 2002 35 38
20. C. Olano, C. Méndez, and J.A. Salas Molecular insights on the biosynthesis of antitumour compounds by actinomycetes Microb Biotechnol 4 2 2011 144 164
21. K.S. Lam Discovery of novel metabolites from marine actinomycetes Current Opinion in Microbiology 9 3 2006 245 251
22. J.B. McAlpine, A.H. Banskota, R.D. Charan, G. Schlingmann, E. Zazopoulos, and M. Piraee et al. Biosynthesis of diazepinomicin/ECO-4601, a Micromonospora secondary metabolite with a novel ring system J Nat Prod 71 2008 1585 1590
23. J.R. Tennant Evaluation of the trypan blue technique for determination of cell viability Transplantation 2 1964 685 694
24. J. Berdy Bioactive microbial metabolites J Antibiot 58 2005 1 26
25. C. Campas Diazepinomicin Drugs Fut 34 5 2009 349
26. H. Lecoeur Nuclear apoptosis detection by flow cytometry: influence of endogenous endonucleases Exp Cell Res 277 1 2002 1 14
27. B. Brune Nitric oxide and apoptosis in mesangial cells Kidney Int 61 3 2002 786 789
28. W.E. Zheng, H. Chen, S.F. Yuan, L.L. Wu, W. Zhang, and H.Y. Sun et al. Overexpression of beta iii-tubulin and survivin associated with drug resistance to docetaxel-based chemotherapy in advanced gastric cancer J BUON 17 2 2012 284 290
29. D.M. Hockenbery, C.D. Giedt, J.W. O'Neill, M.K. Manion, and D.E. Banker Mitochondria and apoptosis: new therapeutic targets Adv Cancer Res 85 2002 203 242
30. J. Henry-Mowatt, C. Dive, J.C. Martinou, and D. James Role of mitochondrial membrane permeabilization in apoptosis and cancer Oncogene 23 2004 2850 2860
31. B. Antonsson, F. Conti, A. Ciavatta, S. Montessuit, S. Lewis, and I. Martinou et al. Inhibition of Bax channel-forming activity by Bcl-2 Science 277 5324 1997 370 372
32. K. Langeswaran, S. Gowthamkumar, S. Vijayaprakash, R. Revathy, and M.P. Balasubramanian Influence of limonin role on Wnt signaling molecule in HepG2 cell line J Nat Sci Biol Med 4 1 2013 126 133
33. C. Campas Diazepinomicin Drug Fut 34 2009 349 351
34. K.K. Wong Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK pathway Recent Pat Anticancer Drug Discov 4 1 2009 28 35
35. D.J. Newman, and M.G. Cragg Natural products as sources of new drugs over the last 25 years J Nat Prod 70 2007 461 477
36. K. Suthindhiran, and K. Kannabiran Cytotoxic and Antimicrobial Potential of Actinomycete Species Saccharopolyspora salina VITSDK4 isolated from the Bay of Bengal Coast of India Am J Infect Dis 5 2 2009 90 98