Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors

ACS Chemical Biology

Volumn 10, Issue 12, 2015, Pages 2716-2724

  Abdul Hay, Samer O ^a   Bannister, Thomas D ^b   Wang, Hui ^b   Cameron, Michael D ^c   Caulfield, Thomas R ^a   Masson, Amandine ^a   Bertrand, Juliette ^a   Howard, Erin A ^a   McGuire, Michael P ^a   Crisafulli, Umberto ^a   Rosenberry, Terrone R ^a   Topper, Caitlyn L ^e   Thompson, Caroline R ^e   Schürer, Stephan C ^c,f   Madoux, Franck ^d   Hodder, Peter ^d   Leissring, Malcolm A ^a,e  

^a MAYO CLINIC   (United States)

^b Department of Chemistry ^*  (United States)

^c Molecular Therapeutics   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; METALLOPROTEINASE INHIBITOR; ENZYME INHIBITOR; HYPERGLYCEMIC AGENT; INSULINASE; THIOL DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL VIABILITY ASSAY; DISULFIDE BOND; DRUG TARGETING; ELECTROPHILICITY; EXTRACELLULAR SPACE; HEK293 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC50; LUMINESCENCE; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; RAT; RING OPENING; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; CYTOSOL; DRUG DELIVERY SYSTEM; ENZYMOLOGY; PRECLINICAL STUDY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

COMPUTER SIMULATION; CYTOSOL; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; EXTRACELLULAR SPACE; INHIBITORY CONCENTRATION 50; INSULIN ANTAGONISTS; INSULYSIN; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 84952641633     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/acschembio.5b00334     Document Type: Article

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