ISCHRUNK - In Silico Approach to Characterization and Reduction of Uncertainty in the Kinetic Models of Genome-scale Metabolic Networks

Metabolic Engineering

Volumn 33, Issue , 2016, Pages 158-168

  Andreozzi, Stefano ^a,b   Miskovic, Ljubisa ^a,b   Hatzimanikatis, Vassily ^a,b  

^a EPFL   (Switzerland)

^b SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

Author keywords

Enzyme saturations; Kinetic parameters; Large scale kinetic models; Machine learning; Monte Carlo sampling; Uncertainty reduction

Indexed keywords

ARTIFICIAL INTELLIGENCE; ENZYMES; ESCHERICHIA COLI; KINETIC PARAMETERS; KINETIC THEORY; KINETICS; LEARNING SYSTEMS; METABOLISM; METABOLITES; MONTE CARLO METHODS; PHYSIOLOGY; THERMODYNAMICS; UNCERTAINTY ANALYSIS;

COMPUTATIONAL METHODOLOGY; ENZYME SATURATION; GENOME-SCALE METABOLIC NETWORK; KINETIC MODELS; METABOLIC FLUX ANALYSIS; METABOLITE CONCENTRATIONS; MONTE CARLO SAMPLING; UNCERTAINTY REDUCTION;

PHYSIOLOGICAL MODELS;

1,4 BUTANEDIOL; ENZYME; FRUCTOSE BISPHOSPHATE; GLUCOSE; NICOTINAMIDE ADENINE DINUCLEOTIDE; 1,4-BUTANEDIOL; BUTANEDIOL; ESCHERICHIA COLI PROTEIN; PROTEOME;

ARTICLE; CITRIC ACID CYCLE; CLASSIFICATION ALGORITHM; ESCHERICHIA COLI; EXTRACELLULAR SPACE; GENOME; GLYCOLYSIS; KINETIC PARAMETERS; MACHINE LEARNING; METABOLIC FLUX ANALYSIS; METABOLITE; MICHAELIS CONSTANT; MICHAELIS MENTEN KINETICS; NONHUMAN; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; RESPIRATORY CHAIN; STEADY STATE; STOICHIOMETRY; THERMODYNAMICS; BACTERIAL GENOME; BIOLOGICAL MODEL; COMPUTER SIMULATION; KINETICS; METABOLISM; METABOLOME; PHYSIOLOGY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; SOFTWARE;

BUTYLENE GLYCOLS; COMPUTER SIMULATION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENOME, BACTERIAL; GLUCOSE; KINETICS; METABOLIC FLUX ANALYSIS; METABOLOME; MODELS, BIOLOGICAL; PROTEOME; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; SOFTWARE;

EID: 84952637898     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2015.10.002     Document Type: Article

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