Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation

Journal of Neuroinflammation

Volumn 12, Issue 1, 2015, Pages

  Mazzola, Maria Antonietta ^a   Raheja, Radhika ^a   Murugaiyan, Gopal ^a   Rajabi, Hasan ^b   Kumar, Deepak ^c   Pertel, Thomas ^a   Regev, Keren ^a   Griffin, Russell ^a   Aly, Lilian ^a   Kivisakk, Pia ^a   Nejad, Parham ^a   Patel, Bonny ^a   Gwanyalla, Nguendab ^a   Hei, Hillary ^a   Glanz, Bonnie ^a   Chitnis, Tanuja ^a   Weiner, Howard L ^a   Gandhi, Roopali ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Fingolimod (FTY720); Granzyme B; IFN ; Multiple sclerosis; TCF 1

Indexed keywords

FINGOLIMOD; GAMMA INTERFERON; GLYCOGEN SYNTHASE KINASE 3BETA; GRANZYME B; LENTIVIRUS VECTOR; PROTEIN KINASE B; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR 7; IMMUNOSUPPRESSIVE AGENT; TCF7 PROTEIN, HUMAN;

ARTICLE; CD4+ T LYMPHOCYTE; CELL MIGRATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG MECHANISM; ENZYME PHOSPHORYLATION; EPIGENETICS; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; LYMPHOCYTE FUNCTION; MULTIPLE SCLEROSIS; PHENOTYPE; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION; TCF7 GENE; UPREGULATION; WESTERN BLOTTING; WNT SIGNALING PATHWAY; BIOSYNTHESIS; DRUG EFFECTS; FEMALE; MALE; METABOLISM; PHYSIOLOGY;

CD4-POSITIVE T-LYMPHOCYTES; FEMALE; FINGOLIMOD HYDROCHLORIDE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MULTIPLE SCLEROSIS; T CELL TRANSCRIPTION FACTOR 1; UP-REGULATION;

EID: 84952011329     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-015-0460-z     Document Type: Article

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