메뉴 건너뛰기




Volumn 27, Issue 1, 2012, Pages 30-38

Immunosuppressive drugs on inducing Ag-specific CD4+CD25+Foxp3+ Treg cells during immune response in vivo

Author keywords

Immunosuppressant; Mouse model; Regulatory T cells; Tolerance

Indexed keywords

CD4 ANTIGEN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; FINGOLIMOD; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2 RECEPTOR ALPHA; LEFLUNOMIDE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TRANSCRIPTION FACTOR FOXP3;

EID: 84864531704     PISSN: 09663274     EISSN: 18785492     Source Type: Journal    
DOI: 10.1016/j.trim.2012.05.001     Document Type: Article
Times cited : (41)

References (54)
  • 1
    • 0033608835 scopus 로고    scopus 로고
    • Immunosuppressive strategies in transplantation
    • Denton M.D., Magee C.C., Sayegh M.H. Immunosuppressive strategies in transplantation. Lancet 1999, 353:1083-1091.
    • (1999) Lancet , vol.353 , pp. 1083-1091
    • Denton, M.D.1    Magee, C.C.2    Sayegh, M.H.3
  • 2
    • 0034061860 scopus 로고    scopus 로고
    • Chronic allograft dysfunction: mechanisms and new approaches to therapy
    • Womer K.L., Vella J.P., Sayegh M.H. Chronic allograft dysfunction: mechanisms and new approaches to therapy. Semin Nephrol 2000, 20:126-147.
    • (2000) Semin Nephrol , vol.20 , pp. 126-147
    • Womer, K.L.1    Vella, J.P.2    Sayegh, M.H.3
  • 3
    • 34247277666 scopus 로고    scopus 로고
    • Foxp3 in control of the regulatory T cell lineage
    • Zheng Y., Rudensky A.Y. Foxp3 in control of the regulatory T cell lineage. Nat Immunol 2007, 8:457-462.
    • (2007) Nat Immunol , vol.8 , pp. 457-462
    • Zheng, Y.1    Rudensky, A.Y.2
  • 4
    • 0034794768 scopus 로고    scopus 로고
    • Challenges to achieving clinical transplantation tolerance
    • Salama A.D., Remuzzi G., Harmon W.E., Sayegh M.H. Challenges to achieving clinical transplantation tolerance. J Clin Invest 2001, 108:943-948.
    • (2001) J Clin Invest , vol.108 , pp. 943-948
    • Salama, A.D.1    Remuzzi, G.2    Harmon, W.E.3    Sayegh, M.H.4
  • 5
    • 48349085577 scopus 로고    scopus 로고
    • New insights into mechanisms of spontaneous liver transplant tolerance: the role of Foxp3-expressing CD25+CD4+ regulatory T cells
    • Li W., Kuhr C.S., Zheng X.X., Carper K., Thomson A.W., Reyes J.D., et al. New insights into mechanisms of spontaneous liver transplant tolerance: the role of Foxp3-expressing CD25+CD4+ regulatory T cells. Am J Transplant 2008, 8:1639-1651.
    • (2008) Am J Transplant , vol.8 , pp. 1639-1651
    • Li, W.1    Kuhr, C.S.2    Zheng, X.X.3    Carper, K.4    Thomson, A.W.5    Reyes, J.D.6
  • 6
    • 34249687073 scopus 로고    scopus 로고
    • The different effects of cyclosporin A and rapamycin on regulatory CD4+CD25+ T cells: potential relationship with transplant tolerance induction
    • Zhao Y. The different effects of cyclosporin A and rapamycin on regulatory CD4+CD25+ T cells: potential relationship with transplant tolerance induction. Expert Rev Clin Immunol 2007, 3:245-249.
    • (2007) Expert Rev Clin Immunol , vol.3 , pp. 245-249
    • Zhao, Y.1
  • 7
    • 29144523592 scopus 로고    scopus 로고
    • Elevated T regulatory cells in long-term stable transplant tolerance in rhesus macaques induced by anti-CD3 immunotoxin and deoxyspergualin
    • Asiedu C.K., Goodwin K.J., Balgansuren G., Jenkins S.M., Le Bas-Bernardet S., Jargal U., et al. Elevated T regulatory cells in long-term stable transplant tolerance in rhesus macaques induced by anti-CD3 immunotoxin and deoxyspergualin. J Immunol 2005, 175:8060-8068.
    • (2005) J Immunol , vol.175 , pp. 8060-8068
    • Asiedu, C.K.1    Goodwin, K.J.2    Balgansuren, G.3    Jenkins, S.M.4    Le Bas-Bernardet, S.5    Jargal, U.6
  • 8
    • 33847218321 scopus 로고    scopus 로고
    • The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice
    • Qu Y., Zhang B., Zhao L., Liu G., Ma H., Rao E., et al. The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice. Transpl Immunol 2007, 17:153-161.
    • (2007) Transpl Immunol , vol.17 , pp. 153-161
    • Qu, Y.1    Zhang, B.2    Zhao, L.3    Liu, G.4    Ma, H.5    Rao, E.6
  • 9
    • 33747889822 scopus 로고    scopus 로고
    • Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipients
    • Segundo D.S., Ruiz J.C., Izquierdo M., Fernandez-Fresnedo G., Gomez-Alamillo C., Merino R., et al. Calcineurin inhibitors, but not rapamycin, reduce percentages of CD4+CD25+FOXP3+ regulatory T cells in renal transplant recipients. Transplantation 2006, 82:550-557.
    • (2006) Transplantation , vol.82 , pp. 550-557
    • Segundo, D.S.1    Ruiz, J.C.2    Izquierdo, M.3    Fernandez-Fresnedo, G.4    Gomez-Alamillo, C.5    Merino, R.6
  • 10
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    • Battaglia M., Stabilini A., Roncarolo M.G. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 2005, 105:4743-4748.
    • (2005) Blood , vol.105 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.G.3
  • 11
    • 33845687004 scopus 로고    scopus 로고
    • A potential side effect of cyclosporin A: inhibition of CD4(+)CD25(+) regulatory T cells in mice
    • Wang H., Zhao L., Sun Z., Sun L., Zhang B., Zhao Y. A potential side effect of cyclosporin A: inhibition of CD4(+)CD25(+) regulatory T cells in mice. Transplantation 2006, 82:1484-1492.
    • (2006) Transplantation , vol.82 , pp. 1484-1492
    • Wang, H.1    Zhao, L.2    Sun, Z.3    Sun, L.4    Zhang, B.5    Zhao, Y.6
  • 12
    • 0032102935 scopus 로고    scopus 로고
    • Rapamycin inhibits the generation of graft-versus-host disease- and graft-versus-leukemia-causing T cells by interfering with the production of Th1 or Th1 cytotoxic cytokines
    • Blazar B.R., Taylor P.A., Panoskaltsis-Mortari A., Vallera D.A. Rapamycin inhibits the generation of graft-versus-host disease- and graft-versus-leukemia-causing T cells by interfering with the production of Th1 or Th1 cytotoxic cytokines. J Immunol 1998, 160:5355-5365.
    • (1998) J Immunol , vol.160 , pp. 5355-5365
    • Blazar, B.R.1    Taylor, P.A.2    Panoskaltsis-Mortari, A.3    Vallera, D.A.4
  • 13
    • 30344449766 scopus 로고    scopus 로고
    • 15-Deoxyspergualin and cyclophosphamide, but not mycophenolate mofetil, prolong survival and attenuate renal disease in a murine model of ANCA-associated crescentic nephritis
    • Birck R., Newman M., Braun C., Neumann I., Nemoto K., Yard B., et al. 15-Deoxyspergualin and cyclophosphamide, but not mycophenolate mofetil, prolong survival and attenuate renal disease in a murine model of ANCA-associated crescentic nephritis. Nephrol Dial Transplant 2006, 21:58-63.
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 58-63
    • Birck, R.1    Newman, M.2    Braun, C.3    Neumann, I.4    Nemoto, K.5    Yard, B.6
  • 14
    • 0034927121 scopus 로고    scopus 로고
    • Mycophenolate mofetil combined with a cyclooxygenase-2 inhibitor ameliorates murine lupus nephritis
    • Zoja C., Benigni A., Noris M., Corna D., Casiraghi F., Pagnoncelli M., et al. Mycophenolate mofetil combined with a cyclooxygenase-2 inhibitor ameliorates murine lupus nephritis. Kidney Int 2001, 60:653-663.
    • (2001) Kidney Int , vol.60 , pp. 653-663
    • Zoja, C.1    Benigni, A.2    Noris, M.3    Corna, D.4    Casiraghi, F.5    Pagnoncelli, M.6
  • 15
    • 1842452888 scopus 로고    scopus 로고
    • Additive effects of leflunomide and tacrolimus in prevention of islet xenograft rejection
    • Zhang L., Qi Z., Wu D., Shan S., Ekberg H. Additive effects of leflunomide and tacrolimus in prevention of islet xenograft rejection. Scand J Immunol 2004, 59:255-260.
    • (2004) Scand J Immunol , vol.59 , pp. 255-260
    • Zhang, L.1    Qi, Z.2    Wu, D.3    Shan, S.4    Ekberg, H.5
  • 16
    • 33745213340 scopus 로고    scopus 로고
    • Induction of regulatory T cells by leflunomide in a murine model of contact allergen sensitivity
    • Weigmann B., Jarman E.R., Sudowe S., Bros M., Knop J., Reske-Kunz A.B. Induction of regulatory T cells by leflunomide in a murine model of contact allergen sensitivity. J Invest Dermatol 2006, 126:1524-1533.
    • (2006) J Invest Dermatol , vol.126 , pp. 1524-1533
    • Weigmann, B.1    Jarman, E.R.2    Sudowe, S.3    Bros, M.4    Knop, J.5    Reske-Kunz, A.B.6
  • 17
    • 70449368171 scopus 로고    scopus 로고
    • Homeostatic proliferation of naive CD8+ T cells depends on CD62L/l-selectin-mediated homing to peripheral LN
    • Schuster K., Gadiot J., Andreesen R., Mackensen A., Gajewski T.F., Blank C. Homeostatic proliferation of naive CD8+ T cells depends on CD62L/l-selectin-mediated homing to peripheral LN. Eur J Immunol 2009, 39:2981-2990.
    • (2009) Eur J Immunol , vol.39 , pp. 2981-2990
    • Schuster, K.1    Gadiot, J.2    Andreesen, R.3    Mackensen, A.4    Gajewski, T.F.5    Blank, C.6
  • 18
    • 70349333237 scopus 로고    scopus 로고
    • The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo
    • Wolf A.M., Eller K., Zeiser R., Durr C., Gerlach U.V., Sixt M., et al. The sphingosine 1-phosphate receptor agonist FTY720 potently inhibits regulatory T cell proliferation in vitro and in vivo. J Immunol 2009, 183:3751-3760.
    • (2009) J Immunol , vol.183 , pp. 3751-3760
    • Wolf, A.M.1    Eller, K.2    Zeiser, R.3    Durr, C.4    Gerlach, U.V.5    Sixt, M.6
  • 19
    • 33846878993 scopus 로고    scopus 로고
    • Cyclophosphamide enhances the antitumor efficacy of adoptively transferred immune cells through the induction of cytokine expression, B-cell and T-cell homeostatic proliferation, and specific tumor infiltration
    • Bracci L., Moschella F., Sestili P., La Sorsa V., Valentini M., Canini I., et al. Cyclophosphamide enhances the antitumor efficacy of adoptively transferred immune cells through the induction of cytokine expression, B-cell and T-cell homeostatic proliferation, and specific tumor infiltration. Clin Cancer Res 2007, 13:644-653.
    • (2007) Clin Cancer Res , vol.13 , pp. 644-653
    • Bracci, L.1    Moschella, F.2    Sestili, P.3    La Sorsa, V.4    Valentini, M.5    Canini, I.6
  • 20
    • 33644749039 scopus 로고    scopus 로고
    • Cyclophosphamide augments inflammation by reducing immunosuppression in a mouse model of allergic airway disease
    • Su Y.C., Rolph M.S., Cooley M.A., Sewell W.A. Cyclophosphamide augments inflammation by reducing immunosuppression in a mouse model of allergic airway disease. J Allergy Clin Immunol 2006, 117:635-641.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 635-641
    • Su, Y.C.1    Rolph, M.S.2    Cooley, M.A.3    Sewell, W.A.4
  • 21
    • 70949097273 scopus 로고    scopus 로고
    • Induction of Foxp3 demethylation increases regulatory CD4+CD25+ T cells and prevents the occurrence of diabetes in mice
    • Zheng Q., Xu Y., Liu Y., Zhang B., Li X., Guo F., et al. Induction of Foxp3 demethylation increases regulatory CD4+CD25+ T cells and prevents the occurrence of diabetes in mice. J Mol Med (Berl) 2009, 87:1191-1205.
    • (2009) J Mol Med (Berl) , vol.87 , pp. 1191-1205
    • Zheng, Q.1    Xu, Y.2    Liu, Y.3    Zhang, B.4    Li, X.5    Guo, F.6
  • 22
    • 0345476290 scopus 로고    scopus 로고
    • Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
    • Wells A.D., Li X.C., Li Y., Walsh M.C., Zheng X.X., Wu Z., et al. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med 1999, 5:1303-1307.
    • (1999) Nat Med , vol.5 , pp. 1303-1307
    • Wells, A.D.1    Li, X.C.2    Li, Y.3    Walsh, M.C.4    Zheng, X.X.5    Wu, Z.6
  • 23
    • 34247643786 scopus 로고    scopus 로고
    • The regulation of Foxp3 expression in regulatory CD4(+)CD25(+)T cells: multiple pathways on the road
    • Zhang L., Zhao Y. The regulation of Foxp3 expression in regulatory CD4(+)CD25(+)T cells: multiple pathways on the road. J Cell Physiol 2007, 211:590-597.
    • (2007) J Cell Physiol , vol.211 , pp. 590-597
    • Zhang, L.1    Zhao, Y.2
  • 24
    • 67650105331 scopus 로고    scopus 로고
    • Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin
    • Strauss L., Czystowska M., Szajnik M., Mandapathil M., Whiteside T.L. Differential responses of human regulatory T cells (Treg) and effector T cells to rapamycin. PLoS One 2009, 4:e5994.
    • (2009) PLoS One , vol.4
    • Strauss, L.1    Czystowska, M.2    Szajnik, M.3    Mandapathil, M.4    Whiteside, T.L.5
  • 25
    • 33845915103 scopus 로고    scopus 로고
    • Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin
    • Strauss L., Whiteside T.L., Knights A., Bergmann C., Knuth A., Zippelius A. Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin. J Immunol 2007, 178:320-329.
    • (2007) J Immunol , vol.178 , pp. 320-329
    • Strauss, L.1    Whiteside, T.L.2    Knights, A.3    Bergmann, C.4    Knuth, A.5    Zippelius, A.6
  • 26
    • 34447324631 scopus 로고    scopus 로고
    • Daily subcutaneous injections of peptide induce CD4+ CD25+ T regulatory cells
    • Dahlberg P.E., Schartner J.M., Timmel A., Seroogy C.M. Daily subcutaneous injections of peptide induce CD4+ CD25+ T regulatory cells. Clin Exp Immunol 2007, 149:226-234.
    • (2007) Clin Exp Immunol , vol.149 , pp. 226-234
    • Dahlberg, P.E.1    Schartner, J.M.2    Timmel, A.3    Seroogy, C.M.4
  • 27
    • 58149291783 scopus 로고    scopus 로고
    • Recurrent superantigen exposure in vivo leads to highly suppressive CD4+CD25+ and CD4+CD25- T cells with anergic and suppressive genetic signatures
    • Schartner J.M., Singh A.M., Dahlberg P.E., Nettenstrom L., Seroogy C.M. Recurrent superantigen exposure in vivo leads to highly suppressive CD4+CD25+ and CD4+CD25- T cells with anergic and suppressive genetic signatures. Clin Exp Immunol 2009, 155:348-356.
    • (2009) Clin Exp Immunol , vol.155 , pp. 348-356
    • Schartner, J.M.1    Singh, A.M.2    Dahlberg, P.E.3    Nettenstrom, L.4    Seroogy, C.M.5
  • 28
    • 65349134526 scopus 로고    scopus 로고
    • The role of positive costimulatory molecules in transplantation and tolerance
    • Agarwal A., Newell K.A. The role of positive costimulatory molecules in transplantation and tolerance. Curr Opin Organ Transplant 2008, 13:366-372.
    • (2008) Curr Opin Organ Transplant , vol.13 , pp. 366-372
    • Agarwal, A.1    Newell, K.A.2
  • 29
    • 34248679904 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects
    • Kang S.M., Tang Q., Bluestone J.A. CD4+CD25+ regulatory T cells in transplantation: progress, challenges and prospects. Am J Transplant 2007, 7:1457-1463.
    • (2007) Am J Transplant , vol.7 , pp. 1457-1463
    • Kang, S.M.1    Tang, Q.2    Bluestone, J.A.3
  • 30
    • 34547204632 scopus 로고    scopus 로고
    • Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment
    • You S., Leforban B., Garcia C., Bach J.F., Bluestone J.A., Chatenoud L. Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc Natl Acad Sci U S A 2007, 104:6335-6340.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 6335-6340
    • You, S.1    Leforban, B.2    Garcia, C.3    Bach, J.F.4    Bluestone, J.A.5    Chatenoud, L.6
  • 32
    • 0037181405 scopus 로고    scopus 로고
    • Compared to mycophenolate mofetil, rapamycin induces significant changes on growth factors and growth factor receptors in the early days post-kidney transplantation
    • Oliveira J.G., Xavier P., Sampaio S.M., Henriques C., Tavares I., Mendes A.A., et al. Compared to mycophenolate mofetil, rapamycin induces significant changes on growth factors and growth factor receptors in the early days post-kidney transplantation. Transplantation 2002, 73:915-920.
    • (2002) Transplantation , vol.73 , pp. 915-920
    • Oliveira, J.G.1    Xavier, P.2    Sampaio, S.M.3    Henriques, C.4    Tavares, I.5    Mendes, A.A.6
  • 33
    • 0034667761 scopus 로고    scopus 로고
    • Rapamycin induces transforming growth factor-beta production by lymphocytes
    • Dodge I.L., Demirci G., Strom T.B., Li X.C. Rapamycin induces transforming growth factor-beta production by lymphocytes. Transplantation 2000, 70:1104-1106.
    • (2000) Transplantation , vol.70 , pp. 1104-1106
    • Dodge, I.L.1    Demirci, G.2    Strom, T.B.3    Li, X.C.4
  • 34
    • 0036143018 scopus 로고    scopus 로고
    • Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation
    • Huynh M.L., Fadok V.A., Henson P.M. Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J Clin Invest 2002, 109:41-50.
    • (2002) J Clin Invest , vol.109 , pp. 41-50
    • Huynh, M.L.1    Fadok, V.A.2    Henson, P.M.3
  • 35
    • 4544241811 scopus 로고    scopus 로고
    • Tolerance, not immunity, crucially depends on IL-2
    • Malek T.R., Bayer A.L. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol 2004, 4:665-674.
    • (2004) Nat Rev Immunol , vol.4 , pp. 665-674
    • Malek, T.R.1    Bayer, A.L.2
  • 36
    • 2442637772 scopus 로고    scopus 로고
    • Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function
    • Thornton A.M., Donovan E.E., Piccirillo C.A., Shevach E.M. Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function. J Immunol 2004, 172:6519-6523.
    • (2004) J Immunol , vol.172 , pp. 6519-6523
    • Thornton, A.M.1    Donovan, E.E.2    Piccirillo, C.A.3    Shevach, E.M.4
  • 38
    • 38049177784 scopus 로고    scopus 로고
    • Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells
    • Zeiser R., Leveson-Gower D.B., Zambricki E.A., Kambham N., Beilhack A., Loh J., et al. Differential impact of mammalian target of rapamycin inhibition on CD4+CD25+Foxp3+ regulatory T cells compared with conventional CD4+ T cells. Blood 2008, 111:453-462.
    • (2008) Blood , vol.111 , pp. 453-462
    • Zeiser, R.1    Leveson-Gower, D.B.2    Zambricki, E.A.3    Kambham, N.4    Beilhack, A.5    Loh, J.6
  • 39
    • 63949085355 scopus 로고    scopus 로고
    • Apoptosis of CD4(+)CD25(high) T cells in response to Sirolimus requires activation of T cell receptor and is modulated by IL-2
    • Molhoek K.R., McSkimming C.C., Olson W.C., Brautigan D.L., Slingluff C.L. Apoptosis of CD4(+)CD25(high) T cells in response to Sirolimus requires activation of T cell receptor and is modulated by IL-2. Cancer Immunol Immunother 2009, 58:867-876.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 867-876
    • Molhoek, K.R.1    McSkimming, C.C.2    Olson, W.C.3    Brautigan, D.L.4    Slingluff, C.L.5
  • 40
    • 78650188983 scopus 로고    scopus 로고
    • An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness
    • Procaccini C., De Rosa V., Galgani M., Abanni L., Cali G., Porcellini A., et al. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity 2010, 33:929-941.
    • (2010) Immunity , vol.33 , pp. 929-941
    • Procaccini, C.1    De Rosa, V.2    Galgani, M.3    Abanni, L.4    Cali, G.5    Porcellini, A.6
  • 41
    • 79952750887 scopus 로고    scopus 로고
    • Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice
    • Wang Y., Camirand G., Lin Y., Froicu M., Deng S., Shlomchik W.D., Lakkis F.G., Rothstein D.M. Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice. J Immunol 2011, 186:2809-2818.
    • (2011) J Immunol , vol.186 , pp. 2809-2818
    • Wang, Y.1    Camirand, G.2    Lin, Y.3    Froicu, M.4    Deng, S.5    Shlomchik, W.D.6    Lakkis, F.G.7    Rothstein, D.M.8
  • 42
    • 77951295311 scopus 로고    scopus 로고
    • Impact of immunosuppressants on the therapeutic efficacy of in vitro-expanded CD4+CD25+Foxp3+ regulatory T cells in allotransplantation
    • Lim D.G., Koo S.K., Park Y.H., Kim Y., Kim H.M., Park C.S., Kim S.C., Han D.J. Impact of immunosuppressants on the therapeutic efficacy of in vitro-expanded CD4+CD25+Foxp3+ regulatory T cells in allotransplantation. Transplantation 2010, 89:928-936.
    • (2010) Transplantation , vol.89 , pp. 928-936
    • Lim, D.G.1    Koo, S.K.2    Park, Y.H.3    Kim, Y.4    Kim, H.M.5    Park, C.S.6    Kim, S.C.7    Han, D.J.8
  • 43
    • 77953806657 scopus 로고    scopus 로고
    • Mycophenolate mofetil modifies kidney tubular injury and Foxp3+ regulatory T cell trafficking during recovery from experimental ischemia-reperfusion
    • Gandolfo M.T., Jang H.R., Bagnasco S.M., Ko G.J., Agreda P., Soloski M.J., Crow M.T., Rabb H. Mycophenolate mofetil modifies kidney tubular injury and Foxp3+ regulatory T cell trafficking during recovery from experimental ischemia-reperfusion. Transpl Immunol 2010, 23:45-52.
    • (2010) Transpl Immunol , vol.23 , pp. 45-52
    • Gandolfo, M.T.1    Jang, H.R.2    Bagnasco, S.M.3    Ko, G.J.4    Agreda, P.5    Soloski, M.J.6    Crow, M.T.7    Rabb, H.8
  • 44
    • 33745633856 scopus 로고    scopus 로고
    • Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production
    • Zeiser R., Nguyen V.H., Beilhack A., Buess M., Schulz S., Baker J., et al. Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production. Blood 2006, 108:390-399.
    • (2006) Blood , vol.108 , pp. 390-399
    • Zeiser, R.1    Nguyen, V.H.2    Beilhack, A.3    Buess, M.4    Schulz, S.5    Baker, J.6
  • 46
    • 41949141343 scopus 로고    scopus 로고
    • Immune-potentiating effects of the chemotherapeutic drug cyclophosphamide
    • Brode S., Cooke A. Immune-potentiating effects of the chemotherapeutic drug cyclophosphamide. Crit Rev Immunol 2008, 28:109-126.
    • (2008) Crit Rev Immunol , vol.28 , pp. 109-126
    • Brode, S.1    Cooke, A.2
  • 47
    • 33847368549 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients
    • Ghiringhelli F., Menard C., Puig P.E., Ladoire S., Roux S., Martin F., et al. Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients. Cancer Immunol Immunother 2007, 56:641-648.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 641-648
    • Ghiringhelli, F.1    Menard, C.2    Puig, P.E.3    Ladoire, S.4    Roux, S.5    Martin, F.6
  • 48
    • 36049009999 scopus 로고    scopus 로고
    • Increase of CD4+ CD25+ regulatory T cells in the peripheral blood of patients with metastatic carcinoma: a Phase I clinical trial using cyclophosphamide and immunotherapy to eliminate CD4+ CD25+ T lymphocytes
    • Audia S., Nicolas A., Cathelin D., Larmonier N., Ferrand C., Foucher P., et al. Increase of CD4+ CD25+ regulatory T cells in the peripheral blood of patients with metastatic carcinoma: a Phase I clinical trial using cyclophosphamide and immunotherapy to eliminate CD4+ CD25+ T lymphocytes. Clin Exp Immunol 2007, 150:523-530.
    • (2007) Clin Exp Immunol , vol.150 , pp. 523-530
    • Audia, S.1    Nicolas, A.2    Cathelin, D.3    Larmonier, N.4    Ferrand, C.5    Foucher, P.6
  • 49
    • 77953730756 scopus 로고    scopus 로고
    • Selective depletion of CD4+CD25+Foxp3+ regulatory T cells by low-dose cyclophosphamide is explained by reduced intracellular ATP levels
    • Zhao J., Cao Y., Lei Z., Yang Z., Zhang B., Huang B. Selective depletion of CD4+CD25+Foxp3+ regulatory T cells by low-dose cyclophosphamide is explained by reduced intracellular ATP levels. Cancer Res 2010, 70:4850-4858.
    • (2010) Cancer Res , vol.70 , pp. 4850-4858
    • Zhao, J.1    Cao, Y.2    Lei, Z.3    Yang, Z.4    Zhang, B.5    Huang, B.6
  • 50
    • 22144475453 scopus 로고    scopus 로고
    • Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells
    • Baan C.C., van der Mast B.J., Klepper M., Mol W.M., Peeters A.M., Korevaar S.S., et al. Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells. Transplantation 2005, 80:110-117.
    • (2005) Transplantation , vol.80 , pp. 110-117
    • Baan, C.C.1    van der Mast, B.J.2    Klepper, M.3    Mol, W.M.4    Peeters, A.M.5    Korevaar, S.S.6
  • 51
    • 31544482746 scopus 로고    scopus 로고
    • Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells
    • Coenen J.J., Koenen H.J., van Rijssen E., Hilbrands L.B., Joosten I. Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells. Blood 2006, 107:1018-1023.
    • (2006) Blood , vol.107 , pp. 1018-1023
    • Coenen, J.J.1    Koenen, H.J.2    van Rijssen, E.3    Hilbrands, L.B.4    Joosten, I.5
  • 52
    • 77958151145 scopus 로고    scopus 로고
    • The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells
    • Liu G, Yang K, Burns S, Shrestha S, Chi H. The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells. Nat Immunol 11:1047-56.
    • Nat Immunol. , vol.11 , pp. 1047-1056
    • Liu, G.1    Yang, K.2    Burns, S.3    Shrestha, S.4    Chi, H.5
  • 54
    • 41149113441 scopus 로고    scopus 로고
    • The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
    • Haxhinasto S., Mathis D., Benoist C. The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med 2008, 205:565-574.
    • (2008) J Exp Med , vol.205 , pp. 565-574
    • Haxhinasto, S.1    Mathis, D.2    Benoist, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.