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Volumn 68, Issue , 2015, Pages 167-176

MicroRNA-Let-7a regulates the function of microglia in inflammation

Author keywords

Brain derived neurotrophic factor (BDNF); BV2 microglia, inflammation; Inducible nitric oxide synthase (iNOS); Interleukin (IL) 10; Interleukin (IL) 4; MicroRNA Let 7a (miR Let 7a)

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 6; MICRORNA; MICRORNA LET 7A; NITRITE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; CASPASE 3; CYTOKINE; LIPOPOLYSACCHARIDE; MESSENGER RNA; MIRNLET7 MICRORNA, MOUSE; NITROPRUSSIDE SODIUM;

EID: 84952008853     PISSN: 10447431     EISSN: 10959327     Source Type: Journal    
DOI: 10.1016/j.mcn.2015.07.004     Document Type: Article
Times cited : (84)

References (67)
  • 1
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros V. The functions of animal microRNAs. Nature 2004, 431:350-355.
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 2
    • 84879470993 scopus 로고    scopus 로고
    • MiRNA-transcription factor interactions: a combinatorial regulation of gene expression
    • Arora S., Rana R., Chhabra A., Jaiswal A., Rani V. MiRNA-transcription factor interactions: a combinatorial regulation of gene expression. Mol. Gen. Genomics. 2013, 288:77-87.
    • (2013) Mol. Gen. Genomics. , vol.288 , pp. 77-87
    • Arora, S.1    Rana, R.2    Chhabra, A.3    Jaiswal, A.4    Rani, V.5
  • 3
    • 0032032424 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures
    • Bhat N.R., Zhang P., Lee J.C., Hogan E.L. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci. 1998, 18:1633-1641.
    • (1998) J. Neurosci. , vol.18 , pp. 1633-1641
    • Bhat, N.R.1    Zhang, P.2    Lee, J.C.3    Hogan, E.L.4
  • 4
    • 58149386890 scopus 로고    scopus 로고
    • MicroRNAs: novel regulators during the immune response
    • Bi Y., Liu G., Yang R. MicroRNAs: novel regulators during the immune response. J. Cell. Physiol. 2009, 218:467-472.
    • (2009) J. Cell. Physiol. , vol.218 , pp. 467-472
    • Bi, Y.1    Liu, G.2    Yang, R.3
  • 5
    • 0037762690 scopus 로고    scopus 로고
    • Neurotrophins and their receptors: a convergence point for many signalling pathways
    • Chao M.V. Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat. Rev. Neurosci. 2003, 4:299-309.
    • (2003) Nat. Rev. Neurosci. , vol.4 , pp. 299-309
    • Chao, M.V.1
  • 6
    • 0026738695 scopus 로고
    • Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
    • Chao C.C., Hu S., Molitor T.W., Shaskan E.G., Peterson P.K. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J. Immunol. 1992, 149:2736-2741.
    • (1992) J. Immunol. , vol.149 , pp. 2736-2741
    • Chao, C.C.1    Hu, S.2    Molitor, T.W.3    Shaskan, E.G.4    Peterson, P.K.5
  • 7
    • 0027197996 scopus 로고
    • Neuroprotective role of IL-4 against activated microglia
    • Chao C.C., Molitor T.W., Hu S. Neuroprotective role of IL-4 against activated microglia. J. Immunol. 1993, 151:1473-1481.
    • (1993) J. Immunol. , vol.151 , pp. 1473-1481
    • Chao, C.C.1    Molitor, T.W.2    Hu, S.3
  • 8
    • 35348929402 scopus 로고    scopus 로고
    • A cellular micro-RNA, let-7i, regulates toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection
    • Chen X.M., Splinter P.L., O'Hara S.P., LaRusso N.F. A cellular micro-RNA, let-7i, regulates toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection. J. Biol. Chem. 2007, 282:28929-28938.
    • (2007) J. Biol. Chem. , vol.282 , pp. 28929-28938
    • Chen, X.M.1    Splinter, P.L.2    O'Hara, S.P.3    LaRusso, N.F.4
  • 9
    • 79951521140 scopus 로고    scopus 로고
    • Coregulation of transcription factors and microRNAs in human transcriptional regulatory network
    • Chen C.Y., Chen S.T., Fuh C.S., Juan H.F., Huang H.C. Coregulation of transcription factors and microRNAs in human transcriptional regulatory network. BMC Bioinforma. 2011, 12(Suppl. 1):S41.
    • (2011) BMC Bioinforma. , vol.12 , pp. S41
    • Chen, C.Y.1    Chen, S.T.2    Fuh, C.S.3    Juan, H.F.4    Huang, H.C.5
  • 11
    • 84922562352 scopus 로고    scopus 로고
    • MiR-21 and let-7 in the Ras and NF-kappaB pathways
    • Choudhury S.N., Li Y. MiR-21 and let-7 in the Ras and NF-kappaB pathways. Microrna 2012, 1:65-69.
    • (2012) Microrna , vol.1 , pp. 65-69
    • Choudhury, S.N.1    Li, Y.2
  • 13
    • 0034525687 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in astrocytes, oligodendrocytes, and microglia/macrophages after spinal cord injury
    • Dougherty K.D., Dreyfus C.F., Black I.B. Brain-derived neurotrophic factor in astrocytes, oligodendrocytes, and microglia/macrophages after spinal cord injury. Neurobiol. Dis. 2000, 7:574-585.
    • (2000) Neurobiol. Dis. , vol.7 , pp. 574-585
    • Dougherty, K.D.1    Dreyfus, C.F.2    Black, I.B.3
  • 14
    • 38349169664 scopus 로고    scopus 로고
    • Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?
    • Filipowicz W., Bhattacharyya S.N., Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?. Nat. Rev. Genet. 2008, 9:102-114.
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 102-114
    • Filipowicz, W.1    Bhattacharyya, S.N.2    Sonenberg, N.3
  • 15
    • 0024408824 scopus 로고
    • Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    • Fiorentino D.F., Bond M.W., Mosmann T.R. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J. Exp. Med. 1989, 170:2081-2095.
    • (1989) J. Exp. Med. , vol.170 , pp. 2081-2095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 17
    • 79951701971 scopus 로고    scopus 로고
    • Targeting TNF-alpha to elucidate and ameliorate neuroinflammation in neurodegenerative diseases
    • Frankola K.A., Greig N.H., Luo W., Tweedie D. Targeting TNF-alpha to elucidate and ameliorate neuroinflammation in neurodegenerative diseases. CNS Neurol. Disord. Drug Targets 2011, 10:391-403.
    • (2011) CNS Neurol. Disord. Drug Targets , vol.10 , pp. 391-403
    • Frankola, K.A.1    Greig, N.H.2    Luo, W.3    Tweedie, D.4
  • 18
    • 84893202052 scopus 로고    scopus 로고
    • Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia
    • Freilich R.W., Woodbury M.E., Ikezu T. Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia. PLoS One 2013, 8:e79416.
    • (2013) PLoS One , vol.8
    • Freilich, R.W.1    Woodbury, M.E.2    Ikezu, T.3
  • 19
    • 0028217132 scopus 로고
    • Requirement for BDNF in activity-dependent survival of cortical neurons
    • Ghosh A., Carnahan J., Greenberg M.E. Requirement for BDNF in activity-dependent survival of cortical neurons. Science 1994, 263:1618-1623.
    • (1994) Science , vol.263 , pp. 1618-1623
    • Ghosh, A.1    Carnahan, J.2    Greenberg, M.E.3
  • 22
    • 84873021276 scopus 로고    scopus 로고
    • Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia
    • Gomes C., Ferreira R., George J., Sanches R., Rodrigues D.I., Goncalves N., Cunha R.A. Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia. J. Neuroinflammation 2013, 10:16.
    • (2013) J. Neuroinflammation , vol.10 , pp. 16
    • Gomes, C.1    Ferreira, R.2    George, J.3    Sanches, R.4    Rodrigues, D.I.5    Goncalves, N.6    Cunha, R.A.7
  • 23
    • 84883790050 scopus 로고    scopus 로고
    • Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock
    • Hagar J.A., Powell D.A., Aachoui Y., Ernst R.K., Miao E.A. Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. Science 2013, 341:1250-1253.
    • (2013) Science , vol.341 , pp. 1250-1253
    • Hagar, J.A.1    Powell, D.A.2    Aachoui, Y.3    Ernst, R.K.4    Miao, E.A.5
  • 24
    • 33646439133 scopus 로고    scopus 로고
    • Activated microglia contribute to the maintenance of chronic pain after spinal cord injury
    • Hains B.C., Waxman S.G. Activated microglia contribute to the maintenance of chronic pain after spinal cord injury. J. Neurosci. 2006, 26:4308-4317.
    • (2006) J. Neurosci. , vol.26 , pp. 4308-4317
    • Hains, B.C.1    Waxman, S.G.2
  • 25
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: active sensor and versatile effector cells in the normal and pathologic brain
    • Hanisch U.K., Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat. Neurosci. 2007, 10:1387-1394.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 26
    • 0031913982 scopus 로고    scopus 로고
    • Inflammatory signals induce neurotrophin expression in human microglial cells
    • Heese K., Hock C., Otten U. Inflammatory signals induce neurotrophin expression in human microglial cells. J. Neurochem. 1998, 70:699-707.
    • (1998) J. Neurochem. , vol.70 , pp. 699-707
    • Heese, K.1    Hock, C.2    Otten, U.3
  • 30
    • 84924747021 scopus 로고    scopus 로고
    • Attenuation of inflammatory-mediated neurotoxicity by Saururus chinensis extract in LPS-induced BV-2 microglia cells via regulation of NF-kappaB signaling and anti-oxidant properties
    • Kim B.W., Koppula S., Park S.Y., Hwang J.W., Park P.J., Lim J.H., Choi D.K. Attenuation of inflammatory-mediated neurotoxicity by Saururus chinensis extract in LPS-induced BV-2 microglia cells via regulation of NF-kappaB signaling and anti-oxidant properties. BMC Complement. Altern. Med. 2014, 14:502.
    • (2014) BMC Complement. Altern. Med. , vol.14 , pp. 502
    • Kim, B.W.1    Koppula, S.2    Park, S.Y.3    Hwang, J.W.4    Park, P.J.5    Lim, J.H.6    Choi, D.K.7
  • 31
    • 71649101716 scopus 로고    scopus 로고
    • Loss of let-7 binding sites resulting from truncations of the 3' untranslated region of HMGA2 mRNA in uterine leiomyomas
    • Klemke M., Meyer A., Hashemi Nezhad M., Belge G., Bartnitzke S., Bullerdiek J. Loss of let-7 binding sites resulting from truncations of the 3' untranslated region of HMGA2 mRNA in uterine leiomyomas. Cancer Genet. Cytogenet. 2010, 196:119-123.
    • (2010) Cancer Genet. Cytogenet. , vol.196 , pp. 119-123
    • Klemke, M.1    Meyer, A.2    Hashemi Nezhad, M.3    Belge, G.4    Bartnitzke, S.5    Bullerdiek, J.6
  • 32
  • 33
    • 24744467358 scopus 로고    scopus 로고
    • Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines
    • Koenigsknecht-Talboo J., Landreth G.E. Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines. J. Neurosci. 2005, 25:8240-8249.
    • (2005) J. Neurosci. , vol.25 , pp. 8240-8249
    • Koenigsknecht-Talboo, J.1    Landreth, G.E.2
  • 34
    • 84875139094 scopus 로고    scopus 로고
    • MicroRNA-92a negatively regulates toll-like receptor (TLR)-triggered inflammatory response in macrophages by targeting MKK4 kinase
    • Lai L., Song Y., Liu Y., Chen Q., Han Q., Chen W., Pan T., Zhang Y., Cao X., Wang Q. MicroRNA-92a negatively regulates toll-like receptor (TLR)-triggered inflammatory response in macrophages by targeting MKK4 kinase. J. Biol. Chem. 2013, 288:7956-7967.
    • (2013) J. Biol. Chem. , vol.288 , pp. 7956-7967
    • Lai, L.1    Song, Y.2    Liu, Y.3    Chen, Q.4    Han, Q.5    Chen, W.6    Pan, T.7    Zhang, Y.8    Cao, X.9    Wang, Q.10
  • 36
    • 78650653944 scopus 로고    scopus 로고
    • MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-beta
    • Louafi F., Martinez-Nunez R.T., Sanchez-Elsner T. MicroRNA-155 targets SMAD2 and modulates the response of macrophages to transforming growth factor-beta. J. Biol. Chem. 2010, 285:41328-41336.
    • (2010) J. Biol. Chem. , vol.285 , pp. 41328-41336
    • Louafi, F.1    Martinez-Nunez, R.T.2    Sanchez-Elsner, T.3
  • 37
    • 84874804934 scopus 로고    scopus 로고
    • Valproic acid attenuates microgliosis in injured spinal cord and purinergic P2X4 receptor expression in activated microglia
    • Lu W.H., Wang C.Y., Chen P.S., Wang J.W., Chuang D.M., Yang C.S., Tzeng S.F. Valproic acid attenuates microgliosis in injured spinal cord and purinergic P2X4 receptor expression in activated microglia. J. Neurosci. Res. 2013, 91:694-705.
    • (2013) J. Neurosci. Res. , vol.91 , pp. 694-705
    • Lu, W.H.1    Wang, C.Y.2    Chen, P.S.3    Wang, J.W.4    Chuang, D.M.5    Yang, C.S.6    Tzeng, S.F.7
  • 38
    • 73049110767 scopus 로고    scopus 로고
    • The multifaceted profile of activated microglia
    • Lynch M.A. The multifaceted profile of activated microglia. Mol. Neurobiol. 2009, 40:139-156.
    • (2009) Mol. Neurobiol. , vol.40 , pp. 139-156
    • Lynch, M.A.1
  • 39
    • 79952810857 scopus 로고    scopus 로고
    • Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity
    • Maezawa I., Zimin P.I., Wulff H., Jin L.W. Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. J. Biol. Chem. 2011, 286:3693-3706.
    • (2011) J. Biol. Chem. , vol.286 , pp. 3693-3706
    • Maezawa, I.1    Zimin, P.I.2    Wulff, H.3    Jin, L.W.4
  • 40
    • 84864249514 scopus 로고    scopus 로고
    • Mechanisms underlying the rapid peroxisome proliferator-activated receptor-gamma-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease
    • Mandrekar-Colucci S., Karlo J.C., Landreth G.E. Mechanisms underlying the rapid peroxisome proliferator-activated receptor-gamma-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. J. Neurosci. 2012, 32:10117-10128.
    • (2012) J. Neurosci. , vol.32 , pp. 10117-10128
    • Mandrekar-Colucci, S.1    Karlo, J.C.2    Landreth, G.E.3
  • 42
    • 84875950146 scopus 로고    scopus 로고
    • IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS
    • Minten C., Terry R., Deffrasnes C., King N.J., Campbell I.L. IFN regulatory factor 8 is a key constitutive determinant of the morphological and molecular properties of microglia in the CNS. PLoS One 2012, 7:e49851.
    • (2012) PLoS One , vol.7
    • Minten, C.1    Terry, R.2    Deffrasnes, C.3    King, N.J.4    Campbell, I.L.5
  • 44
    • 77649340617 scopus 로고    scopus 로고
    • Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation, invasion, and proliferation associated with let-7 down-regulation in retinoblastomas
    • Mu G., Liu H., Zhou F., Xu X., Jiang H., Wang Y., Qu Y. Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation, invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. Hum. Pathol. 2010, 41:493-502.
    • (2010) Hum. Pathol. , vol.41 , pp. 493-502
    • Mu, G.1    Liu, H.2    Zhou, F.3    Xu, X.4    Jiang, H.5    Wang, Y.6    Qu, Y.7
  • 46
    • 0032510798 scopus 로고    scopus 로고
    • Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor
    • Neumann H., Misgeld T., Matsumuro K., Wekerle H. Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:5779-5784.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 5779-5784
    • Neumann, H.1    Misgeld, T.2    Matsumuro, K.3    Wekerle, H.4
  • 48
    • 35148835215 scopus 로고    scopus 로고
    • CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells
    • Ponomarev E.D., Maresz K., Tan Y., Dittel B.N. CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells. J. Neurosci. 2007, 27:10714-10721.
    • (2007) J. Neurosci. , vol.27 , pp. 10714-10721
    • Ponomarev, E.D.1    Maresz, K.2    Tan, Y.3    Dittel, B.N.4
  • 49
    • 78651247933 scopus 로고    scopus 로고
    • MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-alpha-PU.1 pathway
    • Ponomarev E.D., Veremeyko T., Barteneva N., Krichevsky A.M., Weiner H.L. MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-alpha-PU.1 pathway. Nat. Med. 2011, 17:64-70.
    • (2011) Nat. Med. , vol.17 , pp. 64-70
    • Ponomarev, E.D.1    Veremeyko, T.2    Barteneva, N.3    Krichevsky, A.M.4    Weiner, H.L.5
  • 52
    • 52949091534 scopus 로고    scopus 로고
    • The let-7 family of microRNAs
    • Roush S., Slack F.J. The let-7 family of microRNAs. Trends Cell Biol. 2008, 18:505-516.
    • (2008) Trends Cell Biol. , vol.18 , pp. 505-516
    • Roush, S.1    Slack, F.J.2
  • 53
    • 58749093072 scopus 로고    scopus 로고
    • IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia
    • Shimizu E., Kawahara K., Kajizono M., Sawada M., Nakayama H. IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia. J. Immunol. 2008, 181:6503-6513.
    • (2008) J. Immunol. , vol.181 , pp. 6503-6513
    • Shimizu, E.1    Kawahara, K.2    Kajizono, M.3    Sawada, M.4    Nakayama, H.5
  • 55
    • 84924191380 scopus 로고    scopus 로고
    • Neuroinflammation, microglia and mast cells in the pathophysiology of neurocognitive disorders: a review
    • Skaper S.D., Facci L., Giusti P. Neuroinflammation, microglia and mast cells in the pathophysiology of neurocognitive disorders: a review. CNS Neurol. Disord. Drug Targets 2014.
    • (2014) CNS Neurol. Disord. Drug Targets
    • Skaper, S.D.1    Facci, L.2    Giusti, P.3
  • 56
    • 0036154041 scopus 로고    scopus 로고
    • BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells?
    • Stadelmann C., Kerschensteiner M., Misgeld T., Bruck W., Hohlfeld R., Lassmann H. BDNF and gp145trkB in multiple sclerosis brain lesions: neuroprotective interactions between immune and neuronal cells?. Brain 2002, 125:75-85.
    • (2002) Brain , vol.125 , pp. 75-85
    • Stadelmann, C.1    Kerschensteiner, M.2    Misgeld, T.3    Bruck, W.4    Hohlfeld, R.5    Lassmann, H.6
  • 57
    • 33746354022 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner
    • Takeuchi H., Jin S., Wang J., Zhang G., Kawanokuchi J., Kuno R., Sonobe Y., Mizuno T., Suzumura A. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J. Biol. Chem. 2006, 281:21362-21368.
    • (2006) J. Biol. Chem. , vol.281 , pp. 21362-21368
    • Takeuchi, H.1    Jin, S.2    Wang, J.3    Zhang, G.4    Kawanokuchi, J.5    Kuno, R.6    Sonobe, Y.7    Mizuno, T.8    Suzumura, A.9
  • 60
    • 33644768174 scopus 로고    scopus 로고
    • Control of translation and mRNA degradation by miRNAs and siRNAs
    • Valencia-Sanchez M.A., Liu J., Hannon G.J., Parker R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev. 2006, 20:515-524.
    • (2006) Genes Dev. , vol.20 , pp. 515-524
    • Valencia-Sanchez, M.A.1    Liu, J.2    Hannon, G.J.3    Parker, R.4
  • 61
    • 84952045664 scopus 로고    scopus 로고
    • Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer's disease brains and human microglia
    • Walker D.G., Whetzel A.M., Lue L.F. Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer's disease brains and human microglia. Neuroscience 2014.
    • (2014) Neuroscience
    • Walker, D.G.1    Whetzel, A.M.2    Lue, L.F.3
  • 62
    • 26944495173 scopus 로고    scopus 로고
    • MicroRNA function in animal development
    • Wienholds E., Plasterk R.H. MicroRNA function in animal development. FEBS Lett. 2005, 579:5911-5922.
    • (2005) FEBS Lett. , vol.579 , pp. 5911-5922
    • Wienholds, E.1    Plasterk, R.H.2
  • 63
    • 84905003317 scopus 로고    scopus 로고
    • Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i
    • Xie H., Lei N., Gong A.Y., Chen X.M., Hu G. Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i. Hum. Immunol. 2014, 75:760-765.
    • (2014) Hum. Immunol. , vol.75 , pp. 760-765
    • Xie, H.1    Lei, N.2    Gong, A.Y.3    Chen, X.M.4    Hu, G.5
  • 67
    • 33750442559 scopus 로고    scopus 로고
    • Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia
    • Zhao W., Xie W., Xiao Q., Beers D.R., Appel S.H. Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia. J. Neurochem. 2006, 99:1176-1187.
    • (2006) J. Neurochem. , vol.99 , pp. 1176-1187
    • Zhao, W.1    Xie, W.2    Xiao, Q.3    Beers, D.R.4    Appel, S.H.5


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