메뉴 건너뛰기




Volumn 7, Issue , 2015, Pages 51-61

Unmet needs of patients with narcolepsy: Perspectives on emerging treatment options

Author keywords

Cataplexy; GABA B agonists; H3 antagonist; Hypocretin; Immunotherapy

Indexed keywords


EID: 84951905259     PISSN: None     EISSN: 11791608     Source Type: Journal    
DOI: 10.2147/NSS.S56077     Document Type: Review
Times cited : (20)

References (116)
  • 1
    • 84921438674 scopus 로고    scopus 로고
    • Clinical and practical considerations in the pharmacologic management of narcolepsy
    • Thorpy MJ, Dauvilliers Y. Clinical and practical considerations in the pharmacologic management of narcolepsy. Sleep Med. 2015;16(1):9-18.
    • (2015) Sleep Med. , vol.16 , Issue.1 , pp. 9-18
    • Thorpy, M.J.1    Dauvilliers, Y.2
  • 2
    • 84888252514 scopus 로고    scopus 로고
    • Delayed diagnosis, range of severity, and multiple sleep comorbidities: A clinical and polysomnographic analysis of 100 patients of the innsbruck narcolepsy cohort
    • Frauscher B, Ehrmann L, Mitterling T, et al. Delayed diagnosis, range of severity, and multiple sleep comorbidities: a clinical and polysomnographic analysis of 100 patients of the innsbruck narcolepsy cohort. J Clin Sleep Med. 2013;9(8):805-812.
    • (2013) J Clin Sleep Med. , vol.9 , Issue.8 , pp. 805-812
    • Frauscher, B.1    Ehrmann, L.2    Mitterling, T.3
  • 4
    • 0034967934 scopus 로고    scopus 로고
    • Narcolepsy: Clinical features, new pathophysiologic insights, and future perspectives
    • Overeem S, Mignot E, van Dijk JG, Lammers GJ. Narcolepsy: clinical features, new pathophysiologic insights, and future perspectives. J Clin Neurophysiol. 2001;18(2):78-105.
    • (2001) J Clin Neurophysiol. , vol.18 , Issue.2 , pp. 78-105
    • Overeem, S.1    Mignot, E.2    Van Dijk, J.G.3    Lammers, G.J.4
  • 5
    • 33846840794 scopus 로고    scopus 로고
    • Narcolepsy with cataplexy
    • Dauvilliers Y, Arnulf I, Mignot E. Narcolepsy with cataplexy. Lancet. 2007;369(9560):499-511.
    • (2007) Lancet. , vol.369 , Issue.9560 , pp. 499-511
    • Dauvilliers, Y.1    Arnulf, I.2    Mignot, E.3
  • 6
    • 0037172877 scopus 로고    scopus 로고
    • Prevalence of narcolepsy symptomatology and diagnosis in the European general population
    • Ohayon MM, Priest RG, Zulley J, Smirne S, Paiva T. Prevalence of narcolepsy symptomatology and diagnosis in the European general population. Neurology. 2002;58(12):1826-1833.
    • (2002) Neurology. , vol.58 , Issue.12 , pp. 1826-1833
    • Ohayon, M.M.1    Priest, R.G.2    Zulley, J.3    Smirne, S.4    Paiva, T.5
  • 7
    • 84900002785 scopus 로고    scopus 로고
    • Delayed diagnosis of narcolepsy: Characterization and impact
    • Thorpy MJ, Krieger AC. Delayed diagnosis of narcolepsy: characterization and impact. Sleep Med. 2014;15(5):502-507.
    • (2014) Sleep Med. , vol.15 , Issue.5 , pp. 502-507
    • Thorpy, M.J.1    Krieger, A.C.2
  • 8
    • 35048834847 scopus 로고    scopus 로고
    • Health-related quality of life in patients with narcolepsy
    • Dodel R, Peter H, Spottke A, et al. Health-related quality of life in patients with narcolepsy. Sleep Med. 2007;8:733-741.
    • (2007) Sleep Med. , vol.8 , pp. 733-741
    • Dodel, R.1    Peter, H.2    Spottke, A.3
  • 9
    • 84870522806 scopus 로고    scopus 로고
    • The burden of narcolepsy with cataplexy: How disease history and clinical features influence socio-economic outcomes
    • Ingravallo F, Gnucci V, Pizza F, et al. The burden of narcolepsy with cataplexy: how disease history and clinical features influence socio-economic outcomes. Sleep Med. 2012;13:1293-1300.
    • (2012) Sleep Med. , vol.13 , pp. 1293-1300
    • Ingravallo, F.1    Gnucci, V.2    Pizza, F.3
  • 10
    • 84865285099 scopus 로고    scopus 로고
    • Health, social, and economic consequences of narcolepsy: A controlled national study evaluating the societal effect on patients and their partners
    • Jennum P, Ibsen R, Petersen ER, Knudsen S, Kjellberg J. Health, social, and economic consequences of narcolepsy: a controlled national study evaluating the societal effect on patients and their partners. Sleep Med. 2012;13(8):1086-1093.
    • (2012) Sleep Med. , vol.13 , Issue.8 , pp. 1086-1093
    • Jennum, P.1    Ibsen, R.2    Petersen, E.R.3    Knudsen, S.4    Kjellberg, J.5
  • 11
  • 12
    • 0028583080 scopus 로고
    • Psychosocial impact of narcolepsy
    • Broughton WA, Broughton RJ. Psychosocial impact of narcolepsy. Sleep. 1994;17(8 Suppl):S45-S49.
    • (1994) Sleep. , vol.17 , Issue.8 , pp. S45-S49
    • Broughton, W.A.1    Broughton, R.J.2
  • 14
    • 78649443021 scopus 로고    scopus 로고
    • Sleep disorders and accidental risk in a large group of regular registered highway drivers
    • Philip P, Sagaspe P, Lagarde E, et al. Sleep disorders and accidental risk in a large group of regular registered highway drivers. Sleep Med. 2010;11:973-979.
    • (2010) Sleep Med. , vol.11 , pp. 973-979
    • Philip, P.1    Sagaspe, P.2    Lagarde, E.3
  • 15
    • 80755144904 scopus 로고    scopus 로고
    • Overview of management of narcolepsy
    • Goswami M, Pandi-Perumal SR, Thorphy MJ, editors. New York: Springer
    • Nishino S, Kotorii N. Overview of management of narcolepsy. In: Goswami M, Pandi-Perumal SR, Thorphy MJ, editors. Narcolepsy: A Clinical Guide. New York: Springer; 2010:251-265.
    • (2010) Narcolepsy: A Clinical Guide , pp. 251-265
    • Nishino, S.1    Kotorii, N.2
  • 16
    • 36849065939 scopus 로고    scopus 로고
    • Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin
    • Standards of Practice Committee of the American Academy of Sleep Medicine
    • Morgenthaler TI, Kapur VK, Brown T, et al; Standards of Practice Committee of the American Academy of Sleep Medicine. Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin. Sleep. 2007;30(12):1705-1711.
    • (2007) Sleep. , vol.30 , Issue.12 , pp. 1705-1711
    • Morgenthaler, T.I.1    Kapur, V.K.2    Brown, T.3
  • 17
    • 0001209408 scopus 로고
    • The use of Benzedrine for the treatment of narcolepsy
    • Prinzmetal M, Bloomberg W. The use of Benzedrine for the treatment of narcolepsy. JAMA. 1935;105(25):2051-2054.
    • (1935) JAMA. , vol.105 , Issue.25 , pp. 2051-2054
    • Prinzmetal, M.1    Bloomberg, W.2
  • 18
    • 58549096895 scopus 로고    scopus 로고
    • Potential adverse effects of amphetamine treatment on brain and behavior: A review
    • Berman SM, Kuczenski R, McCracken JT, London ED. Potential adverse effects of amphetamine treatment on brain and behavior: a review. Mol Psychiatry. 2009;14(2):123-142.
    • (2009) Mol Psychiatry. , vol.14 , Issue.2 , pp. 123-142
    • Berman, S.M.1    Kuczenski, R.2    McCracken, J.T.3    London, E.D.4
  • 19
    • 0027516491 scopus 로고
    • Amphetamines and narcolepsy: Use of the Stanford database
    • Guilleminault C. Amphetamines and narcolepsy: use of the Stanford database. Sleep. 1993;16(3):199-201.
    • (1993) Sleep. , vol.16 , Issue.3 , pp. 199-201
    • Guilleminault, C.1
  • 20
    • 84868013057 scopus 로고    scopus 로고
    • A practical guide to the therapy of narcolepsy and hypersomnia syndromes
    • Mignot EJ. A practical guide to the therapy of narcolepsy and hypersomnia syndromes. Neurotherapeutics. 2012;9(4):739-752.
    • (2012) Neurotherapeutics. , vol.9 , Issue.4 , pp. 739-752
    • Mignot, E.J.1
  • 21
    • 0025734373 scopus 로고
    • Relative efficacy of drugs for the treatment of sleepiness in narcolepsy
    • Mitler MM, Hajdukovic R. Relative efficacy of drugs for the treatment of sleepiness in narcolepsy. Sleep. 1991;14(3):218-220.
    • (1991) Sleep. , vol.14 , Issue.3 , pp. 218-220
    • Mitler, M.M.1    Hajdukovic, R.2
  • 24
    • 0034455666 scopus 로고    scopus 로고
    • Problems associated with switch to modafinil - A novel alerting agent in narcolepsy
    • Guilleminault C, Aftab FA, Karadeniz D, Philip P, Leger D. Problems associated with switch to modafinil - a novel alerting agent in narcolepsy. Eur J Neurol. 2000;7(4):381-384.
    • (2000) Eur J Neurol. , vol.7 , Issue.4 , pp. 381-384
    • Guilleminault, C.1    Aftab, F.A.2    Karadeniz, D.3    Philip, P.4    Leger, D.5
  • 25
    • 58149379246 scopus 로고    scopus 로고
    • Effective treatment of narcolepsy-cataplexy with duloxetine: A report of three cases
    • Izzi F, Placidi F, Marciani MG, et al. Effective treatment of narcolepsy-cataplexy with duloxetine: a report of three cases. Sleep Med. 2009;10(1):153-154.
    • (2009) Sleep Med. , vol.10 , Issue.1 , pp. 153-154
    • Izzi, F.1    Placidi, F.2    Marciani, M.G.3
  • 26
    • 79951909577 scopus 로고    scopus 로고
    • Case series of 226 γ-hydroxybutyrate-associated deaths: Lethal toxicity and trauma
    • Zvosec DL, Smith SW, Porrata T, Strobl AQ, Dyer JE. Case series of 226 γ-hydroxybutyrate-associated deaths: lethal toxicity and trauma. Am J Emerg Med. 2011;29(3):319-332.
    • (2011) Am J Emerg Med. , vol.29 , Issue.3 , pp. 319-332
    • Zvosec, D.L.1    Smith, S.W.2    Porrata, T.3    Strobl, A.Q.4    Dyer, J.E.5
  • 29
    • 84875627031 scopus 로고    scopus 로고
    • Management of narcolepsy during pregnancy
    • Thorpy M, Zhao CG, Dauvilliers Y. Management of narcolepsy during pregnancy. Sleep Med. 2013;14(4):367-376.
    • (2013) Sleep Med. , vol.14 , Issue.4 , pp. 367-376
    • Thorpy, M.1    Zhao, C.G.2    Dauvilliers, Y.3
  • 30
    • 84893846748 scopus 로고    scopus 로고
    • Orexin neurons suppress narcolepsy via 2 distinct efferent pathways
    • Hasegawa E, Yanagisawa M, Sakurai T, Mieda M. Orexin neurons suppress narcolepsy via 2 distinct efferent pathways. J Clin Invest. 2014;124(2):604-616.
    • (2014) J Clin Invest. , vol.124 , Issue.2 , pp. 604-616
    • Hasegawa, E.1    Yanagisawa, M.2    Sakurai, T.3    Mieda, M.4
  • 31
    • 0034667702 scopus 로고    scopus 로고
    • Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons
    • Bourgin P, Huitrón-Résendiz S, Spier AD, et al. Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons. J Neurosci. 2000;20(20):7760-7765.
    • (2000) J Neurosci. , vol.20 , Issue.20 , pp. 7760-7765
    • Bourgin, P.1    Huitrón-Résendiz, S.2    Spier, A.D.3
  • 32
    • 0035859825 scopus 로고    scopus 로고
    • Arousal effect of orexin A depends on activation of the histaminergic system
    • Huang ZL, Qu WM, Li WD, et al. Arousal effect of orexin A depends on activation of the histaminergic system. Proc Natl Acad Sci U S A. 2001;98(17):9965-9970.
    • (2001) Proc Natl Acad Sci U S A. , vol.98 , Issue.17 , pp. 9965-9970
    • Huang, Z.L.1    Qu, W.M.2    Li, W.D.3
  • 33
    • 0035906548 scopus 로고    scopus 로고
    • Effects on sleep and wakefulness of the injection of hypocretin-1 (orexin-A) into the laterodorsal tegmental nucleus of the cat
    • Xi MC, Morales FR, Chase MH. Effects on sleep and wakefulness of the injection of hypocretin-1 (orexin-A) into the laterodorsal tegmental nucleus of the cat. Brain Res. 2001;901(1-2):259-264.
    • (2001) Brain Res. , vol.901 , Issue.1-2 , pp. 259-264
    • Xi, M.C.1    Morales, F.R.2    Chase, M.H.3
  • 34
    • 1842584959 scopus 로고    scopus 로고
    • Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice
    • Mieda M, Willie JT, Hara J, Sinton CM, Sakurai T, Yanagisawa M. Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice. Proc Natl Acad Sci U S A. 2004;101(13):4649-4654.
    • (2004) Proc Natl Acad Sci U S A. , vol.101 , Issue.13 , pp. 4649-4654
    • Mieda, M.1    Willie, J.T.2    Hara, J.3    Sinton, C.M.4    Sakurai, T.5    Yanagisawa, M.6
  • 36
    • 48949095544 scopus 로고    scopus 로고
    • Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy
    • Mishima K, Fujiki N, Yoshida Y, et al. Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy. Sleep. 2008;31(8):1119-1126.
    • (2008) Sleep. , vol.31 , Issue.8 , pp. 1119-1126
    • Mishima, K.1    Fujiki, N.2    Yoshida, Y.3
  • 37
    • 1642382070 scopus 로고    scopus 로고
    • Effects of IV and ICV hypocretin-1 (orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretin-ligand-deficient narcoleptic dog
    • Fujiki N, Yoshida Y, Ripley B, Mignot E, Nishino S. Effects of IV and ICV hypocretin-1 (orexin A) in hypocretin receptor-2 gene mutated narcoleptic dogs and IV hypocretin-1 replacement therapy in a hypocretin-ligand-deficient narcoleptic dog. Sleep. 2003;26(8):953-959.
    • (2003) Sleep. , vol.26 , Issue.8 , pp. 953-959
    • Fujiki, N.1    Yoshida, Y.2    Ripley, B.3    Mignot, E.4    Nishino, S.5
  • 38
    • 0034570309 scopus 로고    scopus 로고
    • Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs
    • John J, Wu MF, Siegel JM. Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs. Sleep Res Online. 2000;3(1):23-28.
    • (2000) Sleep Res Online. , vol.3 , Issue.1 , pp. 23-28
    • John, J.1    Wu, M.F.2    Siegel, J.M.3
  • 39
    • 57649134261 scopus 로고    scopus 로고
    • Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease
    • Hanson LR, Frey WH 2nd. Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease. BMC Neurosci. 2008;9 Suppl 3:S5.
    • (2008) BMC Neurosci. , vol.9 , pp. S5
    • Hanson, L.R.1    Frey, W.H.2
  • 40
    • 59149092853 scopus 로고    scopus 로고
    • Novel vasoconstrictor formulation to enhance intranasal targeting of neuropeptide therapeutics to the central nervous system
    • Dhuria SV, Hanson LR, Frey WH 2nd. Novel vasoconstrictor formulation to enhance intranasal targeting of neuropeptide therapeutics to the central nervous system. J Pharmacol Exp Ther. 2009;328(1): 312-320.
    • (2009) J Pharmacol Exp Ther. , vol.328 , Issue.1 , pp. 312-320
    • Dhuria, S.V.1    Hanson, L.R.2    Frey, W.H.3
  • 41
    • 37549069954 scopus 로고    scopus 로고
    • Systemic and nasal delivery of orexin-A (hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates
    • Deadwyler SA, Porrino L, Siegel JM, Hampson RE. Systemic and nasal delivery of orexin-A (hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates. J Neurosci. 2007;27(52):14239-14247.
    • (2007) J Neurosci. , vol.27 , Issue.52 , pp. 14239-14247
    • Deadwyler, S.A.1    Porrino, L.2    Siegel, J.M.3    Hampson, R.E.4
  • 42
    • 54949146168 scopus 로고    scopus 로고
    • Olfactory dysfunction in patients with narcolepsy with cataplexy is restored by intranasal orexin a (hypocretin-1)
    • Baier PC, Weinhold SL, Huth V, Gottwald B, Ferstl R, Hinze-Selch D. Olfactory dysfunction in patients with narcolepsy with cataplexy is restored by intranasal orexin a (hypocretin-1). Brain 2008;131(Pt 10): 2734-2741.
    • (2008) Brain , vol.131 , pp. 2734-2741
    • Baier, P.C.1    Weinhold, S.L.2    Huth, V.3    Gottwald, B.4    Ferstl, R.5    Hinze-Selch, D.6
  • 43
    • 84859899795 scopus 로고    scopus 로고
    • Effects of intranasal hypocretin-1 (orexin A) on sleep in narcolepsy with cataplexy
    • Baier PC, Hallschmid M, Seeck-Hirschner M, et al. Effects of intranasal hypocretin-1 (orexin A) on sleep in narcolepsy with cataplexy. Sleep Med. 2011;12(10):941-946.
    • (2011) Sleep Med. , vol.12 , Issue.10 , pp. 941-946
    • Baier, P.C.1    Hallschmid, M.2    Seeck-Hirschner, M.3
  • 44
    • 84859907507 scopus 로고    scopus 로고
    • Intranasal hypocretin-1: Making sense of scents?
    • Lammers GJ. Intranasal hypocretin-1: making sense of scents? Sleep Med. 2011;12(10):939-940.
    • (2011) Sleep Med. , vol.12 , Issue.10 , pp. 939-940
    • Lammers, G.J.1
  • 45
    • 84892516058 scopus 로고    scopus 로고
    • The effect of intranasal orexin-A (hypocretin-1) on sleep, wakefulness and attention in narcolepsy with cataplexy
    • Weinhold SL, Seeck-Hirschner M, Nowak A, Hallschmid M, Göder R, Baier PC. The effect of intranasal orexin-A (hypocretin-1) on sleep, wakefulness and attention in narcolepsy with cataplexy. Behav Brain Res. 2014;262:8-13.
    • (2014) Behav Brain Res. , vol.262 , pp. 8-13
    • Weinhold, S.L.1    Seeck-Hirschner, M.2    Nowak, A.3    Hallschmid, M.4    Göder, R.5    Baier, P.C.6
  • 46
    • 84873388862 scopus 로고    scopus 로고
    • Effects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy men
    • Sun H, Kennedy WP, Wilbraham D. Effects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy men. Sleep. 2013;36(2):259-267.
    • (2013) Sleep. , vol.36 , Issue.2 , pp. 259-267
    • Sun, H.1    Kennedy, W.P.2    Wilbraham, D.3
  • 47
    • 84911154996 scopus 로고    scopus 로고
    • Orexin receptor antagonists - A patent review (2010 to August 2014)
    • Boss C. Orexin receptor antagonists - a patent review (2010 to August 2014). Expert Opin Ther Pat. 2014;24(12):1367-1381.
    • (2014) Expert Opin Ther Pat. , vol.24 , Issue.12 , pp. 1367-1381
    • Boss, C.1
  • 48
    • 84888266137 scopus 로고    scopus 로고
    • Toward an understanding of agonist binding to human orexin-1 and orexin-2 receptors with G-protein-coupled receptor modeling and site-directed mutagenesis
    • Heifetz A, Barker O, Morris GB, Law RJ, Slack M, Biggin PC. Toward an understanding of agonist binding to human orexin-1 and orexin-2 receptors with G-protein-coupled receptor modeling and site-directed mutagenesis. Biochemistry. 2013;52(46):8246-8260.
    • (2013) Biochemistry. , vol.52 , Issue.46 , pp. 8246-8260
    • Heifetz, A.1    Barker, O.2    Morris, G.B.3    Law, R.J.4    Slack, M.5    Biggin, P.C.6
  • 49
    • 84899680582 scopus 로고    scopus 로고
    • Effects of hypocretin/orexin cell transplantation on narcoleptic-like sleep behavior in rats
    • Arias-Carrión O, Murillo-Rodríguez E. Effects of hypocretin/orexin cell transplantation on narcoleptic-like sleep behavior in rats. PLoS One. 2014;9(4):e95342.
    • (2014) PLoS One. , vol.9 , Issue.4 , pp. e95342
    • Arias-Carrión, O.1    Murillo-Rodríguez, E.2
  • 50
    • 84904959625 scopus 로고    scopus 로고
    • Advances in non-dopaminergic treatments for Parkinson's disease
    • Stayte S, Vissel B. Advances in non-dopaminergic treatments for Parkinson's disease. Front Neurosci. 2014;8:113.
    • (2014) Front Neurosci. , vol.8 , pp. 113
    • Stayte, S.1    Vissel, B.2
  • 51
    • 53149147775 scopus 로고    scopus 로고
    • Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice
    • Liu M, Thankachan S, Kaur S, et al. Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice. Eur J Neurosci. 2008;28: 1382-1393.
    • (2008) Eur J Neurosci. , vol.28 , pp. 1382-1393
    • Liu, M.1    Thankachan, S.2    Kaur, S.3
  • 52
    • 79955780626 scopus 로고    scopus 로고
    • Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice
    • Liu M, Blanco-Centurion C, Konadhode R, et al. Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice. J Neurosci. 2011;31:6028-6040.
    • (2011) J Neurosci. , vol.31 , pp. 6028-6040
    • Liu, M.1    Blanco-Centurion, C.2    Konadhode, R.3
  • 53
    • 84871895020 scopus 로고    scopus 로고
    • Effects of orexin gene transfer in the dorsolateral pons in orexin knockout mice
    • Blanco-Centurion C, Liu M, Konadhode R, Pelluru D, Shiromani PJ. Effects of orexin gene transfer in the dorsolateral pons in orexin knockout mice. Sleep. 2013;36(1):31-40.
    • (2013) Sleep. , vol.36 , Issue.1 , pp. 31-40
    • Blanco-Centurion, C.1    Liu, M.2    Konadhode, R.3    Pelluru, D.4    Shiromani, P.J.5
  • 54
  • 55
    • 78650798151 scopus 로고    scopus 로고
    • Histamine H3 receptors and sleep-wake regulation
    • Lin JS, Sergeeva OA, Haas HL. Histamine H3 receptors and sleep-wake regulation. J Pharmacol Exp Ther. 2011;336(1):17-23.
    • (2011) J Pharmacol Exp Ther. , vol.336 , Issue.1 , pp. 17-23
    • Lin, J.S.1    Sergeeva, O.A.2    Haas, H.L.3
  • 56
    • 62549119555 scopus 로고    scopus 로고
    • Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls
    • Nishino S, Sakurai E, Nevsimalova S, et al. Decreased CSF histamine in narcolepsy with and without low CSF hypocretin-1 in comparison to healthy controls. Sleep. 2009;32(2):175-180.
    • (2009) Sleep. , vol.32 , Issue.2 , pp. 175-180
    • Nishino, S.1    Sakurai, E.2    Nevsimalova, S.3
  • 57
    • 84889029747 scopus 로고    scopus 로고
    • Current and emerging options for the drug treatment of narcolepsy
    • De la Herrán-Arita AK, García-García F. Current and emerging options for the drug treatment of narcolepsy. Drugs. 2013;73(16): 1771-1781.
    • (2013) Drugs. , vol.73 , Issue.16 , pp. 1771-1781
    • De La Herrán-Arita, A.K.1    García-García, F.2
  • 58
    • 79958026433 scopus 로고    scopus 로고
    • The histamine H3 receptor: From discovery to clinical trials with pitolisant
    • Schwartz JC. The histamine H3 receptor: from discovery to clinical trials with pitolisant. Br J Pharmacol. 2011;163(4):713-721.
    • (2011) Br J Pharmacol. , vol.163 , Issue.4 , pp. 713-721
    • Schwartz, J.C.1
  • 59
    • 40849137722 scopus 로고    scopus 로고
    • An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: Studies in orexin-/- mice and patients
    • Lin JS, Dauvilliers Y, Arnulf I, et al. An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients. Neurobiol Dis. 2008;30(1):74-83.
    • (2008) Neurobiol Dis. , vol.30 , Issue.1 , pp. 74-83
    • Lin, J.S.1    Dauvilliers, Y.2    Arnulf, I.3
  • 60
    • 84862791691 scopus 로고    scopus 로고
    • Pitolisant, an inverse agonist of the histamine H3 receptor: An alternative stimulant for narcolepsy-cataplexy in teenagers with refractory sleepiness
    • Inocente C, Arnulf I, Bastuji H, et al. Pitolisant, an inverse agonist of the histamine H3 receptor: an alternative stimulant for narcolepsy-cataplexy in teenagers with refractory sleepiness. Clin Neuropharmacol. 2012;35(2):55-60.
    • (2012) Clin Neuropharmacol. , vol.35 , Issue.2 , pp. 55-60
    • Inocente, C.1    Arnulf, I.2    Bastuji, H.3
  • 61
    • 84885378478 scopus 로고    scopus 로고
    • Pitolisant versus placebo or modafinil in patients with narcolepsy: A double-blind randomised trial
    • HARMONY I study group
    • Dauvilliers Y, Bassetti C, Lammers GJ, et al; HARMONY I study group. Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial. Lancet Neurol. 2013;12(11):1068-1075.
    • (2013) Lancet Neurol. , vol.12 , Issue.11 , pp. 1068-1075
    • Dauvilliers, Y.1    Bassetti, C.2    Lammers, G.J.3
  • 62
    • 10744226168 scopus 로고    scopus 로고
    • Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice
    • Kaupmann K, Cryan JF, Wellendorph P, et al. Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice. Eur J Neurosci. 2003;18(10):2722-2730.
    • (2003) Eur J Neurosci. , vol.18 , Issue.10 , pp. 2722-2730
    • Kaupmann, K.1    Cryan, J.F.2    Wellendorph, P.3
  • 63
    • 77958586336 scopus 로고    scopus 로고
    • Differential effects of GABAB receptor subtypes, {gamma}-hydroxybutyric acid, and baclofen on EEG activity and sleep regulation
    • Vienne J, Bettler B, Franken P, Tafti M. Differential effects of GABAB receptor subtypes, {gamma}-hydroxybutyric acid, and baclofen on EEG activity and sleep regulation. J Neurosci. 2010;30(42):14194-14204.
    • (2010) J Neurosci. , vol.30 , Issue.42 , pp. 14194-14204
    • Vienne, J.1    Bettler, B.2    Franken, P.3    Tafti, M.4
  • 64
    • 66349107313 scopus 로고    scopus 로고
    • Narcolepsy: Action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybate
    • Huang YS, Guilleminault C. Narcolepsy: action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybate. Pediatr Neurol. 2009;41(1):9-16.
    • (2009) Pediatr Neurol. , vol.41 , Issue.1 , pp. 9-16
    • Huang, Y.S.1    Guilleminault, C.2
  • 65
    • 84899848319 scopus 로고    scopus 로고
    • GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy
    • Black SW, Morairty SR, Chen TM, et al. GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy. J Neurosci. 2014; 34(19):6485-6494.
    • (2014) J Neurosci. , vol.34 , Issue.19 , pp. 6485-6494
    • Black, S.W.1    Morairty, S.R.2    Chen, T.M.3
  • 66
    • 84900387901 scopus 로고    scopus 로고
    • Clinical potential, safety, and tolerability of arbaclofen in the treatment of autism spectrum disorder
    • Frye RE. Clinical potential, safety, and tolerability of arbaclofen in the treatment of autism spectrum disorder. Drug Healthc Patient Saf. 2014;6:69-76.
    • (2014) Drug Healthc Patient Saf. , vol.6 , pp. 69-76
    • Frye, R.E.1
  • 67
    • 0022364873 scopus 로고
    • Thyrotropin-releasing hormone and the pituitary. New insights into the mechanisms of stimulated secretion and clinical usage
    • Kolesnick RN, Gershengorn MC. Thyrotropin-releasing hormone and the pituitary. New insights into the mechanisms of stimulated secretion and clinical usage. Am J Med. 1985;79(6):729-739.
    • (1985) Am J Med. , vol.79 , Issue.6 , pp. 729-739
    • Kolesnick, R.N.1    Gershengorn, M.C.2
  • 68
    • 77950860422 scopus 로고    scopus 로고
    • Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputs
    • Nillni EA. Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputs. Front Neuroendocrinol. 2010;31(2):134-156.
    • (2010) Front Neuroendocrinol. , vol.31 , Issue.2 , pp. 134-156
    • Nillni, E.A.1
  • 69
    • 64949145980 scopus 로고    scopus 로고
    • TRH-receptor-type-2-deficient mice are euthyroid and exhibit increased depression and reduced anxiety phenotypes
    • Sun Y, Zupan B, Raaka BM, Toth M, Gershengorn MC. TRH-receptor-type-2-deficient mice are euthyroid and exhibit increased depression and reduced anxiety phenotypes. Neuropsychopharmacology. 2009;34(6): 1601-1608.
    • (2009) Neuropsychopharmacology. , vol.34 , Issue.6 , pp. 1601-1608
    • Sun, Y.1    Zupan, B.2    Raaka, B.M.3    Toth, M.4    Gershengorn, M.C.5
  • 70
    • 0026047021 scopus 로고
    • Muscle denervation increases thyrotropin-releasing hormone (TRH) biosynthesis in the rat medullary raphe
    • Van den Bergh P, Octave JN, Lechan RM. Muscle denervation increases thyrotropin-releasing hormone (TRH) biosynthesis in the rat medullary raphe. Brain Res. 1991;566(1-2):219-224.
    • (1991) Brain Res. , vol.566 , Issue.1-2 , pp. 219-224
    • Van Den Bergh, P.1    Octave, J.N.2    Lechan, R.M.3
  • 71
    • 80052937152 scopus 로고    scopus 로고
    • Taltirelin, a thyrotropin-releasing hormone analog, alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory pain
    • Eto K, Kim SK, Nabekura J, Ishibashi H. Taltirelin, a thyrotropin-releasing hormone analog, alleviates mechanical allodynia through activation of descending monoaminergic neurons in persistent inflammatory pain. Brain Res. 2011;1414:50-57.
    • (2011) Brain Res. , vol.1414 , pp. 50-57
    • Eto, K.1    Kim, S.K.2    Nabekura, J.3    Ishibashi, H.4
  • 72
    • 0032571346 scopus 로고    scopus 로고
    • An update on the CNS actions of TRH and its analogs
    • Horita A. An update on the CNS actions of TRH and its analogs. Life Sci. 1998;62:1443-1448.
    • (1998) Life Sci. , vol.62 , pp. 1443-1448
    • Horita, A.1
  • 73
    • 33746308184 scopus 로고    scopus 로고
    • The TRH neuron: A hypothalamic integrator of energy metabolism
    • Lechan RM, Fekete C. The TRH neuron: a hypothalamic integrator of energy metabolism. Prog Brain Res. 2006;153:209-235.
    • (2006) Prog Brain Res. , vol.153 , pp. 209-235
    • Lechan, R.M.1    Fekete, C.2
  • 75
    • 0029157656 scopus 로고
    • Treatment with thyrotropin-releasing hormone (TRH) in patients with traumatic spinal cord injuries
    • Pitts LH, Ross A, Chase GA, Faden AI. Treatment with thyrotropin-releasing hormone (TRH) in patients with traumatic spinal cord injuries. J Neurotrauma. 1995;12(3):235-243.
    • (1995) J Neurotrauma. , vol.12 , Issue.3 , pp. 235-243
    • Pitts, L.H.1    Ross, A.2    Chase, G.A.3    Faden, A.I.4
  • 76
    • 84922276023 scopus 로고    scopus 로고
    • First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models
    • Kelly JA, Boyle NT, Cole N, et al. First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models. Neuropharmacology. 2015;89:193-203.
    • (2015) Neuropharmacology. , vol.89 , pp. 193-203
    • Kelly, J.A.1    Boyle, N.T.2    Cole, N.3
  • 77
    • 84863981956 scopus 로고    scopus 로고
    • Thyrotropin-releasing hormone as a treatment for cancer-related fatigue: A randomized controlled study
    • Kamath J, Feinn R, Winokur A. Thyrotropin-releasing hormone as a treatment for cancer-related fatigue: a randomized controlled study. Support Care Cancer. 2012;20(8):1745-1753.
    • (2012) Support Care Cancer. , vol.20 , Issue.8 , pp. 1745-1753
    • Kamath, J.1    Feinn, R.2    Winokur, A.3
  • 78
    • 83055186451 scopus 로고    scopus 로고
    • L-pGlu-(2-propyl)-L-His-L-ProNH2 attenuates 4-aminopyridine-induced epileptiform activity and sodium current: A possible action of new thyrotropin-releasing hormone analog for its anticonvulsant potential
    • Sah N, Rajput SK, Singh JN, et al. L-pGlu-(2-propyl)-L-His-L-ProNH2 attenuates 4-aminopyridine-induced epileptiform activity and sodium current: a possible action of new thyrotropin-releasing hormone analog for its anticonvulsant potential. Neuroscience. 2011;199:74-85.
    • (2011) Neuroscience. , vol.199 , pp. 74-85
    • Sah, N.1    Rajput, S.K.2    Singh, J.N.3
  • 79
    • 70350703427 scopus 로고    scopus 로고
    • Oral administration of the thyrotropin-releasing hormone (TRH) analogue, taltireline hydrate, in spinal muscular atrophy
    • Kato Z, Okuda M, Okumura Y, et al. Oral administration of the thyrotropin-releasing hormone (TRH) analogue, taltireline hydrate, in spinal muscular atrophy. J Child Neurol. 2009;24(8):1010-1012.
    • (2009) J Child Neurol. , vol.24 , Issue.8 , pp. 1010-1012
    • Kato, Z.1    Okuda, M.2    Okumura, Y.3
  • 80
    • 14044265763 scopus 로고    scopus 로고
    • Excitatory effects of thyrotropin-releasing hormone in the thalamus
    • Broberger C, McCormick DA. Excitatory effects of thyrotropin-releasing hormone in the thalamus. J Neurosci. 2005;25(7):1664-1673.
    • (2005) J Neurosci. , vol.25 , Issue.7 , pp. 1664-1673
    • Broberger, C.1    McCormick, D.A.2
  • 81
    • 80054889131 scopus 로고    scopus 로고
    • Novel thyrotropin-releasing hormone analogs: A patent review
    • Khomane KS, Meena CL, Jain R, Bansal AK. Novel thyrotropin-releasing hormone analogs: a patent review. Expert Opin Ther Pat. 2011;21(11):1673-1691.
    • (2011) Expert Opin Ther Pat. , vol.21 , Issue.11 , pp. 1673-1691
    • Khomane, K.S.1    Meena, C.L.2    Jain, R.3    Bansal, A.K.4
  • 82
    • 0015265240 scopus 로고
    • On the half life of thyrotropin-releasing hormone in rats
    • Redding TW, Schally AV. On the half life of thyrotropin-releasing hormone in rats. Neuroendocrinology. 1972;9(4):250-256.
    • (1972) Neuroendocrinology. , vol.9 , Issue.4 , pp. 250-256
    • Redding, T.W.1    Schally, A.V.2
  • 83
    • 79952077009 scopus 로고    scopus 로고
    • Synthesis, receptor binding, and CNS pharmacological studies of new thyrotropin-releasing hormone (TRH) analogues
    • Monga V, Meena C, Rajput S, et al. Synthesis, receptor binding, and CNS pharmacological studies of new thyrotropin-releasing hormone (TRH) analogues. ChemMedChem. 2011;6(3):531-543.
    • (2011) ChemMedChem. , vol.6 , Issue.3 , pp. 531-543
    • Monga, V.1    Meena, C.2    Rajput, S.3
  • 84
    • 0030753896 scopus 로고    scopus 로고
    • Effects of thyrotropin-releasing hormone and its analogs on daytime sleepiness and cataplexy in canine narcolepsy
    • Nishino S, Arrigoni J, Shelton J, Kanbayashi T, Dement WC, Mignot E. Effects of thyrotropin-releasing hormone and its analogs on daytime sleepiness and cataplexy in canine narcolepsy. J Neurosci. 1997; 17(16):6401-6408.
    • (1997) J Neurosci. , vol.17 , Issue.16 , pp. 6401-6408
    • Nishino, S.1    Arrigoni, J.2    Shelton, J.3    Kanbayashi, T.4    Dement, W.C.5    Mignot, E.6
  • 85
    • 0343517646 scopus 로고    scopus 로고
    • Chronic oral administration of CG-3703, a thyrotropin releasing hormone analog, increases wake and decreases cataplexy in canine narcolepsy
    • Riehl J, Honda K, Kwan M, Hong J, Mignot E, Nishino S. Chronic oral administration of CG-3703, a thyrotropin releasing hormone analog, increases wake and decreases cataplexy in canine narcolepsy. Neuropsychopharmacology. 2000;23(1):34-45.
    • (2000) Neuropsychopharmacology. , vol.23 , Issue.1 , pp. 34-45
    • Riehl, J.1    Honda, K.2    Kwan, M.3    Hong, J.4    Mignot, E.5    Nishino, S.6
  • 86
    • 61649095016 scopus 로고    scopus 로고
    • Chemistry and biology of thyrotropin-releasing hormone (TRH) and its analogs
    • Monga V, Meena CL, Kaur N, Jain R. Chemistry and biology of thyrotropin-releasing hormone (TRH) and its analogs. Curr Med Chem. 2008;15(26):2718-2733.
    • (2008) Curr Med Chem. , vol.15 , Issue.26 , pp. 2718-2733
    • Monga, V.1    Meena, C.L.2    Kaur, N.3    Jain, R.4
  • 87
    • 84878617543 scopus 로고    scopus 로고
    • Thyrotropin-releasing hormone receptor type 1 (TRH-R1), not TRH-R2, primarily mediates taltirelin actions in the CNS of mice
    • Thirunarayanan N, Nir EA, Raaka BM, Gershengorn MC. Thyrotropin-releasing hormone receptor type 1 (TRH-R1), not TRH-R2, primarily mediates taltirelin actions in the CNS of mice. Neuropsychopharmacology. 2013;38(6):950-956.
    • (2013) Neuropsychopharmacology. , vol.38 , Issue.6 , pp. 950-956
    • Thirunarayanan, N.1    Nir, E.A.2    Raaka, B.M.3    Gershengorn, M.C.4
  • 89
    • 31844440852 scopus 로고    scopus 로고
    • Lack of behavioral tolerance by repeated treatment with taltirelin hydrate, a thyrotropin-releasing hormone analog, in rats
    • Asai H, Asahi T, Yamamura M, Yamauchi-Kohno R, Saito A. Lack of behavioral tolerance by repeated treatment with taltirelin hydrate, a thyrotropin-releasing hormone analog, in rats. Pharmacol Biochem Behav. 2005;82(4):646-651.
    • (2005) Pharmacol Biochem Behav. , vol.82 , Issue.4 , pp. 646-651
    • Asai, H.1    Asahi, T.2    Yamamura, M.3    Yamauchi-Kohno, R.4    Saito, A.5
  • 90
    • 64849092435 scopus 로고    scopus 로고
    • Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons
    • Hara J, Gerashchenko D, Wisor JP, Sakurai T, Xie X, Kilduff TS. Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons. J Neurosci. 2009;29(12): 3705-3714.
    • (2009) J Neurosci. , vol.29 , Issue.12 , pp. 3705-3714
    • Hara, J.1    Gerashchenko, D.2    Wisor, J.P.3    Sakurai, T.4    Xie, X.5    Kilduff, T.S.6
  • 92
    • 65549114213 scopus 로고    scopus 로고
    • Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone
    • Parmentier R, Kolbaev S, Klyuch BP, et al. Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone. J Neurosci. 2009;29(14):4471-4483.
    • (2009) J Neurosci. , vol.29 , Issue.14 , pp. 4471-4483
    • Parmentier, R.1    Kolbaev, S.2    Klyuch, B.P.3
  • 93
    • 84863296844 scopus 로고    scopus 로고
    • Thyrotropin-releasing hormone (TRH) inhibits melanin-concentrating hormone neurons: Implications for TRH-mediated anorexic and arousal actions
    • Zhang X, van den Pol AN. Thyrotropin-releasing hormone (TRH) inhibits melanin-concentrating hormone neurons: implications for TRH-mediated anorexic and arousal actions. J Neurosci. 2012;32(9): 3032-3043.
    • (2012) J Neurosci. , vol.32 , Issue.9 , pp. 3032-3043
    • Zhang, X.1    Van Den Pol, A.N.2
  • 94
    • 66649111903 scopus 로고    scopus 로고
    • Narcolepsy is strongly associated with the T-cell receptor alpha locus
    • Hallmayer J, Faraco J, Lin L, et al. Narcolepsy is strongly associated with the T-cell receptor alpha locus. Nat Genet. 2009;41:708-711.
    • (2009) Nat Genet. , vol.41 , pp. 708-711
    • Hallmayer, J.1    Faraco, J.2    Lin, L.3
  • 95
    • 77956633514 scopus 로고    scopus 로고
    • Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy
    • Hor H, Kutalik Z, Dauvilliers Y, et al. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nat Genet. 2010;42:786-789.
    • (2010) Nat Genet. , vol.42 , pp. 786-789
    • Hor, H.1    Kutalik, Z.2    Dauvilliers, Y.3
  • 96
    • 77949667777 scopus 로고    scopus 로고
    • Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients
    • Cvetkovic-Lopes V, Bayer L, Dorsaz S, et al. Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients. J Clin Invest. 2010;120:713-719.
    • (2010) J Clin Invest. , vol.120 , pp. 713-719
    • Cvetkovic-Lopes, V.1    Bayer, L.2    Dorsaz, S.3
  • 97
    • 77954353102 scopus 로고    scopus 로고
    • Anti-Tribbles homolog 2 autoantibodies in Japanese patients with narcolepsy
    • Toyoda H, Tanaka S, Miyagawa T, Honda Y, Tokynaga K, Honda M. Anti-Tribbles homolog 2 autoantibodies in Japanese patients with narcolepsy. Sleep. 2010;33:875-878.
    • (2010) Sleep. , vol.33 , pp. 875-878
    • Toyoda, H.1    Tanaka, S.2    Miyagawa, T.3    Honda, Y.4    Tokynaga, K.5    Honda, M.6
  • 98
    • 77954369866 scopus 로고    scopus 로고
    • Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy
    • Kawashima M, Lin L, Tanaka S, et al. Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy. Sleep. 2010;33:869-874.
    • (2010) Sleep. , vol.33 , pp. 869-874
    • Kawashima, M.1    Lin, L.2    Tanaka, S.3
  • 99
    • 77954365814 scopus 로고    scopus 로고
    • The trouble with Tribbles: Do antibodies against TRIB2 cause narcolepsy?
    • Lim AS, Scammell TE. The trouble with Tribbles: do antibodies against TRIB2 cause narcolepsy? Sleep. 2010;33(7):857-858.
    • (2010) Sleep. , vol.33 , Issue.7 , pp. 857-858
    • Lim, A.S.1    Scammell, T.E.2
  • 100
    • 84860390294 scopus 로고    scopus 로고
    • Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China
    • Han F, Lin L, Warby SC, et al. Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. Ann Neurol. 2011;70:410-417.
    • (2011) Ann Neurol. , vol.70 , pp. 410-417
    • Han, F.1    Lin, L.2    Warby, S.C.3
  • 101
    • 84859027226 scopus 로고    scopus 로고
    • Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland
    • Partinen M, Saarenpää-Heikkilä O, Ilveskoski I, et al. Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland. PLoS One. 2012;7:e33723.
    • (2012) PLoS One. , vol.7 , pp. e33723
    • Partinen, M.1    Saarenpää-Heikkilä, O.2    Ilveskoski, I.3
  • 102
    • 84881660400 scopus 로고    scopus 로고
    • Incidence of narcolepsy in Norwegian children and adolescents after vaccination against H1N1 influenza A
    • Heier MS, Gautvik KM, Wannag E, et al. Incidence of narcolepsy in Norwegian children and adolescents after vaccination against H1N1 influenza A. Sleep Med. 2013;14:867-871.
    • (2013) Sleep Med. , vol.14 , pp. 867-871
    • Heier, M.S.1    Gautvik, K.M.2    Wannag, E.3
  • 103
    • 84899102996 scopus 로고    scopus 로고
    • Narcolepsy, 2009 A(H1N1) pandemic influenza, and pandemic influenza vaccinations: What is known and unknown about the neurological disorder, the role for autoimmunity, and vaccine adjuvants
    • Ahmed SS, Schur PH, MacDonald NE, Steinman L. Narcolepsy, 2009 A(H1N1) pandemic influenza, and pandemic influenza vaccinations: what is known and unknown about the neurological disorder, the role for autoimmunity, and vaccine adjuvants. J Autoimmun. 2014;50: 1-11.
    • (2014) J Autoimmun. , vol.50 , pp. 1-11
    • Ahmed, S.S.1    Schur, P.H.2    MacDonald, N.E.3    Steinman, L.4
  • 104
    • 67349139579 scopus 로고    scopus 로고
    • No persistent effect of intravenous immunoglobulins in patients with narcolepsy with cataplexy
    • Valko PO, Khatami R, Baumann CR, Bassetti CL. No persistent effect of intravenous immunoglobulins in patients with narcolepsy with cataplexy. J Neurol. 2008;255(12):1900-1903.
    • (2008) J Neurol. , vol.255 , Issue.12 , pp. 1900-1903
    • Valko, P.O.1    Khatami, R.2    Baumann, C.R.3    Bassetti, C.L.4
  • 105
    • 56349137577 scopus 로고    scopus 로고
    • Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy
    • Plazzi G, Poli F, Franceschini C, et al. Intravenous high-dose immunoglobulin treatment in recent onset childhood narcolepsy with cataplexy. J Neurol. 2008;255(10):1549-1554.
    • (2008) J Neurol. , vol.255 , Issue.10 , pp. 1549-1554
    • Plazzi, G.1    Poli, F.2    Franceschini, C.3
  • 106
    • 9644288106 scopus 로고    scopus 로고
    • Successful management of cataplexy with intravenous immunoglobulins shortly after narcolepsy onset
    • Dauvilliers Y, Carlander B, Rivier F, Touchon J, Tafti M. Successful management of cataplexy with intravenous immunoglobulins shortly after narcolepsy onset. Ann Neurol. 2004;56:905-908.
    • (2004) Ann Neurol. , vol.56 , pp. 905-908
    • Dauvilliers, Y.1    Carlander, B.2    Rivier, F.3    Touchon, J.4    Tafti, M.5
  • 107
    • 33745714458 scopus 로고    scopus 로고
    • Follow-up of four narcolepsy patients treated with intravenous immunoglobulins
    • Dauvilliers Y. Follow-up of four narcolepsy patients treated with intravenous immunoglobulins. Ann Neurol. 2006;60(1):153.
    • (2006) Ann Neurol. , vol.60 , Issue.1 , pp. 153
    • Dauvilliers, Y.1
  • 108
    • 0346887119 scopus 로고    scopus 로고
    • Clinical efficacy of high-dose intravenous immunoglobulins near the onset of narcolepsy in a 10-year-old boy
    • Lecendreux M, Maret S, Bassetti C, Mouren MC, Tafti M. Clinical efficacy of high-dose intravenous immunoglobulins near the onset of narcolepsy in a 10-year-old boy. J Sleep Res. 2003;12(4):347-348.
    • (2003) J Sleep Res. , vol.12 , Issue.4 , pp. 347-348
    • Lecendreux, M.1    Maret, S.2    Bassetti, C.3    Mouren, M.C.4    Tafti, M.5
  • 109
    • 20444379398 scopus 로고    scopus 로고
    • Variable response to intravenous immunoglobulin therapy in childhood narcolepsy
    • Abstract
    • Zuberi SM, Mignot E, Ling L, et al. Variable response to intravenous immunoglobulin therapy in childhood narcolepsy. J Sleep Res. 2004; 13(Suppl 1):828. Abstract.
    • (2004) J Sleep Res. , vol.13 , pp. 828
    • Zuberi, S.M.1    Mignot, E.2    Ling, L.3
  • 110
    • 24644509681 scopus 로고    scopus 로고
    • Late-onset narcolepsy presenting as rapidly progressing muscle weakness: Response to plasmapheresis
    • Chen W, Black J, Call P, Mignot E. Late-onset narcolepsy presenting as rapidly progressing muscle weakness: response to plasmapheresis. Ann Neurol. 2005;58(3):489-490.
    • (2005) Ann Neurol. , vol.58 , Issue.3 , pp. 489-490
    • Chen, W.1    Black, J.2    Call, P.3    Mignot, E.4
  • 111
    • 0033710848 scopus 로고    scopus 로고
    • Reduced number of hypocretin neurons in human narcolepsy
    • Thannickal TC, Moore RY, Nienhuis R, et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron. 2000;27(3):469-474.
    • (2000) Neuron. , vol.27 , Issue.3 , pp. 469-474
    • Thannickal, T.C.1    Moore, R.Y.2    Nienhuis, R.3
  • 112
    • 84863784166 scopus 로고    scopus 로고
    • A remarkable effect of alemtuzumab in a patient suffering from narcolepsy with cataplexy
    • Donjacour CE, Lammers GJ. A remarkable effect of alemtuzumab in a patient suffering from narcolepsy with cataplexy. J Sleep Res. 2012;21(4):479-480.
    • (2012) J Sleep Res. , vol.21 , Issue.4 , pp. 479-480
    • Donjacour, C.E.1    Lammers, G.J.2
  • 113
    • 78049232715 scopus 로고    scopus 로고
    • Antigen-specific immunotherapy of autoimmune and allergic diseases
    • Sabatos-Peyton CA, Verhagen J, Wraith DC. Antigen-specific immunotherapy of autoimmune and allergic diseases. Curr Opin Immunol. 2010;22(5):609-615.
    • (2010) Curr Opin Immunol. , vol.22 , Issue.5 , pp. 609-615
    • Sabatos-Peyton, C.A.1    Verhagen, J.2    Wraith, D.C.3
  • 115
    • 0036889653 scopus 로고    scopus 로고
    • A single-site, double-blind, placebo-controlled, dose-ranging study of YKP10A - A putative, new antidepressant
    • Amsterdam JD, Brunswick DJ, Hundert M. A single-site, double-blind, placebo-controlled, dose-ranging study of YKP10A - a putative, new antidepressant. Prog Neuropsychopharmacol Biol Psychiatry. 2002; 26(7-8):1333-1338.
    • (2002) Prog Neuropsychopharmacol Biol Psychiatry. , vol.26 , Issue.7-8 , pp. 1333-1338
    • Amsterdam, J.D.1    Brunswick, D.J.2    Hundert, M.3
  • 116
    • 84953421762 scopus 로고    scopus 로고
    • Efficacy and safety of oral ADX-N05 for the treatment of excessive daytime sleepiness in adults with narcolepsy: Results of a randomized, double-blind, placebo-controlled trial [abstract]
    • May 31-June 4,; Minneapolis, MN. Abstract LBA4
    • Black J, Swick T, Feldman N, et al. Efficacy and safety of oral ADX-N05 for the treatment of excessive daytime sleepiness in adults with narcolepsy: results of a randomized, double-blind, placebo-controlled trial [abstract]. Presented at: 28th Annual Meeting of the Associated Professional Sleep Societies (SLEEP); May 31-June 4, 2014; Minneapolis, MN. Abstract LBA4.
    • (2014) Presented At: 28th Annual Meeting of the Associated Professional Sleep Societies (SLEEP)
    • Black, J.1    Swick, T.2    Feldman, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.