메뉴 건너뛰기




Volumn 34, Issue 6, 2009, Pages 1601-1608

TRH-receptor-type-2-deficient mice are euthyroid and exhibit increased depression and reduced anxiety phenotypes

Author keywords

Anxiety; Behavioral changes; Depression; Thyrotropin releasing hormone; Thyrotropin releasing hormone receptors; TRHR2 deficient mouse

Indexed keywords

GLUCOSE; PROLACTIN; PROTIRELIN RECEPTOR; THYROTROPIN; THYROXINE;

EID: 64949145980     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2008.217     Document Type: Article
Times cited : (39)

References (45)
  • 1
    • 0242383482 scopus 로고    scopus 로고
    • Decreased thyrotropin-releasing hormone gene expression in the hypothalamic para-ventricular nucleus of patients with major depression
    • Alkemade A, Unmehopa UA, Brouwer JP, Hoogendijk WJ, Wiersinga WM, Swaab DF et al (2003). Decreased thyrotropin-releasing hormone gene expression in the hypothalamic para-ventricular nucleus of patients with major depression. Mol Psychiatry 8: 838-839.
    • (2003) Mol Psychiatry , vol.8 , pp. 838-839
    • Alkemade, A.1    Unmehopa, U.A.2    Brouwer, J.P.3    Hoogendijk, W.J.4    Wiersinga, W.M.5    Swaab, D.F.6
  • 2
    • 0025148388 scopus 로고
    • Nocturnal serum thyrotropin (TSH) surge and the TSH response to TSH-releasing hormone: Dissociated behavior in untreated depressives
    • Bartalena L, Placidi GF, Martino E, Falcone M, Pellegrini L, Dell'Osso L et al (1990). Nocturnal serum thyrotropin (TSH) surge and the TSH response to TSH-releasing hormone: dissociated behavior in untreated depressives. J Clin Endocrinol Metab 71: 650-655.
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 650-655
    • Bartalena, L.1    Placidi, G.F.2    Martino, E.3    Falcone, M.4    Pellegrini, L.5    Dell'Osso, L.6
  • 3
    • 41449112209 scopus 로고    scopus 로고
    • The rostral anterior cingulate cortex modulates the efficiency of amygdala-dependent fear learning
    • Bissiere S, Plachta N, Hoyer D, McAllister KH, Olpe HR, Grace AA et al (2008). The rostral anterior cingulate cortex modulates the efficiency of amygdala-dependent fear learning. Biol Psychiatry 63: 821-831.
    • (2008) Biol Psychiatry , vol.63 , pp. 821-831
    • Bissiere, S.1    Plachta, N.2    Hoyer, D.3    McAllister, K.H.4    Olpe, H.R.5    Grace, A.A.6
  • 4
    • 0033610805 scopus 로고    scopus 로고
    • Cloning and characterization of a cDNA encoding a novel subtype of rat thyrotropin-releasing hormone receptor
    • Cao J, O'Donnell D, Vu H, Payza K, Pou C, Godbout C et al (1998). Cloning and characterization of a cDNA encoding a novel subtype of rat thyrotropin-releasing hormone receptor. J Biol Chem 273: 32281-32287.
    • (1998) J Biol Chem , vol.273 , pp. 32281-32287
    • Cao, J.1    O'Donnell, D.2    Vu, H.3    Payza, K.4    Pou, C.5    Godbout, C.6
  • 5
    • 0036570222 scopus 로고    scopus 로고
    • Assessing antidepressant activity in rodents: Recent developments and future needs
    • Cryan JF, Markou A, Lucki I (2002). Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol Sci 23: 238-245.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 238-245
    • Cryan, J.F.1    Markou, A.2    Lucki, I.3
  • 6
    • 0027101754 scopus 로고
    • Two isoforms of the thyrotropin-releasing hormone receptor generated by alternative splicing have indistinguishable functional properties
    • de la Pena P, Delgado LM, del Camino D, Barros F (1992). Two isoforms of the thyrotropin-releasing hormone receptor generated by alternative splicing have indistinguishable functional properties. J Biol Chem 267: 25703-25708.
    • (1992) J Biol Chem , vol.267 , pp. 25703-25708
    • de la Pena, P.1    Delgado, L.M.2    del Camino, D.3    Barros, F.4
  • 7
    • 0029917507 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 is a negative regulator of bone growth
    • Deng C, Wynshaw-Boris A, Zhou F, Kuo A, Leder P (1996). Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell 84: 911-921.
    • (1996) Cell , vol.84 , pp. 911-921
    • Deng, C.1    Wynshaw-Boris, A.2    Zhou, F.3    Kuo, A.4    Leder, P.5
  • 8
    • 19844379585 scopus 로고    scopus 로고
    • Recent advances in animal models of chronic antidepressant effects: The novelty-induced hypophagia test
    • Dulawa SC, Hen R (2005). Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test. Neurosci Biobehav Rev 29: 771-783.
    • (2005) Neurosci Biobehav Rev , vol.29 , pp. 771-783
    • Dulawa, S.C.1    Hen, R.2
  • 9
    • 2942662069 scopus 로고    scopus 로고
    • Effects of chronic fluoxetine in animal models of anxiety and depression
    • Dulawa SC, Holick KA, Gundersen B, Hen R (2004). Effects of chronic fluoxetine in animal models of anxiety and depression. Neuropsychopharmacology 29: 1321-1330.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 1321-1330
    • Dulawa, S.C.1    Holick, K.A.2    Gundersen, B.3    Hen, R.4
  • 10
    • 0030423668 scopus 로고    scopus 로고
    • Functional classification of antidepressants based on antagonism of swim stress-induced fos-like immunoreactivity
    • Duncan GE, Knapp DJ, Johnson KB, Breese GR (1996). Functional classification of antidepressants based on antagonism of swim stress-induced fos-like immunoreactivity. J Pharmacol Exp Ther 277: 1076-1089.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1076-1089
    • Duncan, G.E.1    Knapp, D.J.2    Johnson, K.B.3    Breese, G.R.4
  • 12
    • 0037405712 scopus 로고    scopus 로고
    • The thyrotropin-releasing hormone (TRH) hypothesis of homeostatic regulation: Implications for TRH-based therapeutics
    • Gary KA, Sevarino KA, Yarbrough GG, Prange Jr AJ, Winokur A (2003). The thyrotropin-releasing hormone (TRH) hypothesis of homeostatic regulation: implications for TRH-based therapeutics. J Pharmacol Exp Ther 305: 410-416.
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 410-416
    • Gary, K.A.1    Sevarino, K.A.2    Yarbrough, G.G.3    Prange Jr, A.J.4    Winokur, A.5
  • 13
    • 34447621590 scopus 로고    scopus 로고
    • cAMP response element-binding protein deficiency allows for increased neurogenesis and a rapid onset of antidepressant response
    • Gur TL, Conti AC, Holden J, Bechtholt AJ, Hill TE, Lucki I et al (2007). cAMP response element-binding protein deficiency allows for increased neurogenesis and a rapid onset of antidepressant response. J Neurosci 27: 7860-7868.
    • (2007) J Neurosci , vol.27 , pp. 7860-7868
    • Gur, T.L.1    Conti, A.C.2    Holden, J.3    Bechtholt, A.J.4    Hill, T.E.5    Lucki, I.6
  • 15
    • 0035165706 scopus 로고    scopus 로고
    • Cloning of two thyrotropin-releasing hormone receptor subtypes from a lower vertebrate (Catostomus com-mersoni): Functional expression, gene structure, and evolution
    • Harder S, Dammann O, Buck F, Zwiers H, Lederis K, Richter D et al (2001a). Cloning of two thyrotropin-releasing hormone receptor subtypes from a lower vertebrate (Catostomus com-mersoni): functional expression, gene structure, and evolution. Gen Comp Endocrinol 124: 236-245.
    • (2001) Gen Comp Endocrinol , vol.124 , pp. 236-245
    • Harder, S.1    Dammann, O.2    Buck, F.3    Zwiers, H.4    Lederis, K.5    Richter, D.6
  • 16
    • 0035092112 scopus 로고    scopus 로고
    • Regulator of G protein signaling 4 suppresses basal and thyrotropin releasing-hormone (TRH)-stimulated signaling by two mouse TRH receptors, TRH-R(1) and TRH-R(2)
    • Harder S, Lu X, Wang W, Buck F, Gershengorn MC, Bruhn TO (2001b). Regulator of G protein signaling 4 suppresses basal and thyrotropin releasing-hormone (TRH)-stimulated signaling by two mouse TRH receptors, TRH-R(1) and TRH-R(2). Endocrinology 142: 1188-1194.
    • (2001) Endocrinology , vol.142 , pp. 1188-1194
    • Harder, S.1    Lu, X.2    Wang, W.3    Buck, F.4    Gershengorn, M.C.5    Bruhn, T.O.6
  • 18
    • 0036331378 scopus 로고    scopus 로고
    • Gender differences in the symptoms of major depression in opposite-sex dizygotic twin pairs
    • Khan AA, Gardner CO, Prescott CA, Kendler KS (2002). Gender differences in the symptoms of major depression in opposite-sex dizygotic twin pairs. Am J Psychiatry 159: 1427-1429.
    • (2002) Am J Psychiatry , vol.159 , pp. 1427-1429
    • Khan, A.A.1    Gardner, C.O.2    Prescott, C.A.3    Kendler, K.S.4
  • 19
    • 0028849431 scopus 로고
    • Pyroglutamyl-phenylalanyl-proline amide attenuates thyrotropin-releasing hormone-stimulated insulin secretion in perifused rat islets and insulin-secreting clonal beta-cell lines
    • Kulkarni RN, Wang ZL, Akinsanya KO, Bennet WM, Wang RM, Smith DM et al (1995). Pyroglutamyl-phenylalanyl-proline amide attenuates thyrotropin-releasing hormone-stimulated insulin secretion in perifused rat islets and insulin-secreting clonal beta-cell lines. Endocrinology 136: 5155-5164.
    • (1995) Endocrinology , vol.136 , pp. 5155-5164
    • Kulkarni, R.N.1    Wang, Z.L.2    Akinsanya, K.O.3    Bennet, W.M.4    Wang, R.M.5    Smith, D.M.6
  • 20
    • 3042826859 scopus 로고    scopus 로고
    • Expression of thyrotropin-releasing hormone receptor in immortalized beta-cell lines and rat pancreas
    • Luo LG, Yano N (2004). Expression of thyrotropin-releasing hormone receptor in immortalized beta-cell lines and rat pancreas. J Endocrinol 181: 401-412.
    • (2004) J Endocrinol , vol.181 , pp. 401-412
    • Luo, L.G.1    Yano, N.2
  • 22
    • 0142042988 scopus 로고    scopus 로고
    • Validation of a simple, ethologically relevant paradigm for assessing anxiety in mice
    • Merali Z, Levac C, Anisman H (2003). Validation of a simple, ethologically relevant paradigm for assessing anxiety in mice. Biol Psychiatry 54: 552-565.
    • (2003) Biol Psychiatry , vol.54 , pp. 552-565
    • Merali, Z.1    Levac, C.2    Anisman, H.3
  • 23
    • 64949157481 scopus 로고    scopus 로고
    • High levels of TRH receptors activate programmed cell death in human pancreatic precursors
    • in press
    • Mulla CM, Geras-Raaka E, Raaka BM, Gershengorn MC (2008). High levels of TRH receptors activate programmed cell death in human pancreatic precursors. Pancreas 2009 (in press).
    • (2008) Pancreas
    • Mulla, C.M.1    Geras-Raaka, E.2    Raaka, B.M.3    Gershengorn, M.C.4
  • 24
    • 0034463026 scopus 로고    scopus 로고
    • TRH-R2 exhibits similar binding and acute signaling but distinct regulation and anatomic distribution compared with TRH-R1
    • O'Dowd BF, Lee DK, Huang W, Nguyen T, Cheng R, Liu Y et al (2000). TRH-R2 exhibits similar binding and acute signaling but distinct regulation and anatomic distribution compared with TRH-R1. Mol Endocrinol 14: 183-193.
    • (2000) Mol Endocrinol , vol.14 , pp. 183-193
    • O'Dowd, B.F.1    Lee, D.K.2    Huang, W.3    Nguyen, T.4    Cheng, R.5    Liu, Y.6
  • 25
    • 0033220002 scopus 로고    scopus 로고
    • Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test
    • Page ME, Detke MJ, Dalvi A, Kirby LG, Lucki I (1999). Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test. Psychopharmacology (Berl) 147: 162-167.
    • (1999) Psychopharmacology (Berl) , vol.147 , pp. 162-167
    • Page, M.E.1    Detke, M.J.2    Dalvi, A.3    Kirby, L.G.4    Lucki, I.5
  • 27
    • 25144437513 scopus 로고    scopus 로고
    • TRH-like antidepressant peptide, pyroglutamyltyroslyprolineamide, occurs in rat brain
    • Pekary AE, Faull KF, Paulson M, Lloyd RL, Sattin A (2005). TRH-like antidepressant peptide, pyroglutamyltyroslyprolineamide, occurs in rat brain. J Mass Spectrom 40: 1232-1236.
    • (2005) J Mass Spectrom , vol.40 , pp. 1232-1236
    • Pekary, A.E.1    Faull, K.F.2    Paulson, M.3    Lloyd, R.L.4    Sattin, A.5
  • 28
    • 33845214620 scopus 로고    scopus 로고
    • Circadian rhythms of TRH-like peptide levels in rat brain
    • Pekary AE, Stevens SA, Sattin A (2006). Circadian rhythms of TRH-like peptide levels in rat brain. Brain Res 1125: 67-76.
    • (2006) Brain Res , vol.1125 , pp. 67-76
    • Pekary, A.E.1    Stevens, S.A.2    Sattin, A.3
  • 29
    • 0018196837 scopus 로고
    • Behavioural despair' in rats and mice: Strain differences and the effects of imipramine
    • Porsolt RD, Bertin A, Jalfre M (1978). 'Behavioural despair' in rats and mice: strain differences and the effects of imipramine. Eur J Pharmacol 51: 291-294.
    • (1978) Eur J Pharmacol , vol.51 , pp. 291-294
    • Porsolt, R.D.1    Bertin, A.2    Jalfre, M.3
  • 30
    • 2542457313 scopus 로고    scopus 로고
    • Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism
    • Rabeler R, Mittag J, Geffers L, Ruther U, Leitges M, Parlow AF et al (2004). Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism. Mol Endocrinol 18: 1450-1460.
    • (2004) Mol Endocrinol , vol.18 , pp. 1450-1460
    • Rabeler, R.1    Mittag, J.2    Geffers, L.3    Ruther, U.4    Leitges, M.5    Parlow, A.F.6
  • 31
    • 0032982679 scopus 로고    scopus 로고
    • The role of TRH and related peptides in the mechanism of action of ECT
    • Sattin A (1999). The role of TRH and related peptides in the mechanism of action of ECT. J Ect 15: 76-92.
    • (1999) J Ect , vol.15 , pp. 76-92
    • Sattin, A.1
  • 32
    • 50649096598 scopus 로고    scopus 로고
    • Escitalopram regulates expression of TRH and TRH-like peptides in rat brain and peripheral tissues
    • Sattin A, Pekary AE, Blood J (2008). Escitalopram regulates expression of TRH and TRH-like peptides in rat brain and peripheral tissues. Neuroendocrinology 88: 135-146.
    • (2008) Neuroendocrinology , vol.88 , pp. 135-146
    • Sattin, A.1    Pekary, A.E.2    Blood, J.3
  • 33
    • 0027415845 scopus 로고
    • Functional expression and molecular characterization of the thyrotrophin- releasing hormone receptor from the rat anterior pituitary gland
    • Sellar RE, Taylor PL, Lamb RF, Zabavnik J, Anderson L, Eidne KA (1993). Functional expression and molecular characterization of the thyrotrophin- releasing hormone receptor from the rat anterior pituitary gland. J Mol Endocrinol 10: 199-206.
    • (1993) J Mol Endocrinol , vol.10 , pp. 199-206
    • Sellar, R.E.1    Taylor, P.L.2    Lamb, R.F.3    Zabavnik, J.4    Anderson, L.5    Eidne, K.A.6
  • 34
    • 0034655423 scopus 로고    scopus 로고
    • Genetic inactivation of the serotonin(1A) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety
    • Sibille E, Pavlides C, Benke D, Toth M (2000). Genetic inactivation of the serotonin(1A) receptor in mice results in downregulation of major GABA(A) receptor alpha subunits, reduction of GABA(A) receptor binding, and benzodiazepine-resistant anxiety. J Neurosci 20: 2758-2765.
    • (2000) J Neurosci , vol.20 , pp. 2758-2765
    • Sibille, E.1    Pavlides, C.2    Benke, D.3    Toth, M.4
  • 35
    • 0032751399 scopus 로고    scopus 로고
    • Corticotropin-releasing hormone receptor subtypes and emotion
    • Steckler T, Holsboer F (1999). Corticotropin-releasing hormone receptor subtypes and emotion. Biol Psychiatry 46: 1480-1508.
    • (1999) Biol Psychiatry , vol.46 , pp. 1480-1508
    • Steckler, T.1    Holsboer, F.2
  • 36
    • 0025607860 scopus 로고
    • Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor
    • Straub RE, Frech GC, Joho RH, Gershengorn MC (1990). Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor. Proc Natl Acad Sci USA 87: 9514-9518.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9514-9518
    • Straub, R.E.1    Frech, G.C.2    Joho, R.H.3    Gershengorn, M.C.4
  • 37
    • 0038025925 scopus 로고    scopus 로고
    • Thyrotropin-releasing hormone receptors - similarities and differences
    • Sun Y, Lu X, Gershengorn MC (2003). Thyrotropin-releasing hormone receptors - similarities and differences. J Mol Endocrinol 30: 87-97.
    • (2003) J Mol Endocrinol , vol.30 , pp. 87-97
    • Sun, Y.1    Lu, X.2    Gershengorn, M.C.3
  • 38
    • 0031730115 scopus 로고    scopus 로고
    • Cloning and characterization of the chicken thyrotropin-releasing hormone receptor
    • Sun YM, Millar RP, Ho H, Gershengorn MC, Illing N (1998). Cloning and characterization of the chicken thyrotropin-releasing hormone receptor. Endocrinology 139: 3390-3398.
    • (1998) Endocrinology , vol.139 , pp. 3390-3398
    • Sun, Y.M.1    Millar, R.P.2    Ho, H.3    Gershengorn, M.C.4    Illing, N.5
  • 39
    • 0031600790 scopus 로고    scopus 로고
    • Molecular cloning of bovine thyrotropin-releasing hormone receptor gene
    • Takata M, Shimada Y, Ikeda A, Sekikawa K (1998). Molecular cloning of bovine thyrotropin-releasing hormone receptor gene. J Vet Med Sci 60: 123-127.
    • (1998) J Vet Med Sci , vol.60 , pp. 123-127
    • Takata, M.1    Shimada, Y.2    Ikeda, A.3    Sekikawa, K.4
  • 40
    • 12644251037 scopus 로고    scopus 로고
    • Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene
    • Yamada M, Saga Y, Shibusawa N, Hirato J, Murakami M, Iwasaki T et al (1997). Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene. Proc Natl Acad Sci USA 94: 10862-10867.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10862-10867
    • Yamada, M.1    Saga, Y.2    Shibusawa, N.3    Hirato, J.4    Murakami, M.5    Iwasaki, T.6
  • 41
    • 0034635595 scopus 로고    scopus 로고
    • Expression of thyrotropin-releasing hormone (TRH) receptor subtype 1 in mouse pancreatic islets and HIT-T15, an insulin-secreting clonal beta cell line
    • Yamada M, Shibusawa N, Hashida T, Ozawa A, Monden T, Satoh T et al (2000). Expression of thyrotropin-releasing hormone (TRH) receptor subtype 1 in mouse pancreatic islets and HIT-T15, an insulin-secreting clonal beta cell line. Life Sci 66: 1119-1125.
    • (2000) Life Sci , vol.66 , pp. 1119-1125
    • Yamada, M.1    Shibusawa, N.2    Hashida, T.3    Ozawa, A.4    Monden, T.5    Satoh, T.6
  • 42
    • 0032584068 scopus 로고    scopus 로고
    • The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
    • Yang X, Li C, Xu X, Deng C (1998). The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad Sci USA 95: 3667-3672.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3667-3672
    • Yang, X.1    Li, C.2    Xu, X.3    Deng, C.4
  • 43
    • 35448937671 scopus 로고    scopus 로고
    • Thyrotropin-releasing hormone (TRH) in the neuroaxis: Therapeutic effects reflect physiological functions and molecular actions
    • Yarbrough GG, Kamath J, Winokur A, Prange Jr AJ (2007). Thyrotropin-releasing hormone (TRH) in the neuroaxis: therapeutic effects reflect physiological functions and molecular actions. Med Hypotheses 69: 1249-1256.
    • (2007) Med Hypotheses , vol.69 , pp. 1249-1256
    • Yarbrough, G.G.1    Kamath, J.2    Winokur, A.3    Prange Jr, A.J.4
  • 44
    • 35648986624 scopus 로고    scopus 로고
    • Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior
    • Zeng H, Schimpf BA, Rohde AD, Pavlova MN, Gragerov A, Bergmann JE (2007). Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior. Mol Endocrinol 21: 2795-2804.
    • (2007) Mol Endocrinol , vol.21 , pp. 2795-2804
    • Zeng, H.1    Schimpf, B.A.2    Rohde, A.D.3    Pavlova, M.N.4    Gragerov, A.5    Bergmann, J.E.6
  • 45
    • 0026772938 scopus 로고
    • Molecular cloning of a complementary deoxyribonucleic acid encoding the thyrotropin-releasing hormone receptor and regulation of its messenger ribonucleic acid in rat GH cells
    • Zhao D, Yang J, Jones KE, Gerald C, Suzuki Y, Hogan PG et al (1992). Molecular cloning of a complementary deoxyribonucleic acid encoding the thyrotropin-releasing hormone receptor and regulation of its messenger ribonucleic acid in rat GH cells. Endocrinology 130: 3529-3536.
    • (1992) Endocrinology , vol.130 , pp. 3529-3536
    • Zhao, D.1    Yang, J.2    Jones, K.E.3    Gerald, C.4    Suzuki, Y.5    Hogan, P.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.