Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro

Oncotarget

Volumn 6, Issue 39, 2015, Pages 41464-41478

  Mahli, Abdo ^a   Thasler, Wolfgang E ^b   Patsenker, Eleonora ^c   Müller, Sebastian ^d   Stickel, Felix ^c   Müller, Martina ^a   Seitz, Helmut K ^d   Cederbaum, Arthur I ^e   Hellerbrand, Claus ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF BERN   (Switzerland)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol; Autophagy; CYP2E1; Pathology section; Steatosis

Indexed keywords

ALCOHOL; CYTOCHROME P450 2E1; OLEIC ACID; STRESS ACTIVATED PROTEIN KINASE; TRIACYLGLYCEROL; AUTACOID; CYTOCHROME P450 2E1 INHIBITOR;

ALCOHOL METABOLISM; ARTICLE; AUTOPHAGY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FATTY LIVER; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; LIPID PEROXIDATION; LIPID STORAGE; LIPOGENESIS; LIVER CELL; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; DRUG EFFECTS; DRUG POTENTIATION; ENZYMOLOGY; FATTY LIVER, ALCOHOLIC; HEP-G2 CELL LINE; LIVER; METABOLISM; PATHOLOGY; PRIMARY CELL CULTURE;

AUTOPHAGY; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 CYP2E1 INHIBITORS; DRUG SYNERGISM; ETHANOL; FATTY LIVER, ALCOHOLIC; HEP G2 CELLS; HEPATOCYTES; HUMANS; INFLAMMATION MEDIATORS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPID PEROXIDATION; LIPOGENESIS; LIVER; OLEIC ACID; OXIDATIVE STRESS; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; TRIGLYCERIDES;

EID: 84951845021     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6203     Document Type: Article

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