Palmitic acid induces autophagy in hepatocytes via JNK2 activation

Acta Pharmacologica Sinica

Volumn 35, Issue 4, 2014, Pages 504-512

  Tu, Qian Qian ^a   Zheng, Rui Ying ^b   Li, Juan ^b   Hu, Liang ^a,c   Chang, Yan Xin ^a   Li, Liang ^a   Li, Min Hong ^d   Wang, Ruo Yu ^d   Huang, Dan Dan ^a   Wu, Meng Chao ^d   Hu, He Ping ^d   Chen, Lei ^a,e   Wang, Hong Yang ^a,e  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c No 150 Central Hospital of PLA   (China)

^d Eastern Hepatobiliary Surgery Hospital   (China)

^e National Center for Liver Cancer   (China)

Author keywords

3MA; Apoptosis; Atg5; Autophagy; Beclin1; Free fatty acid; Hepatocytes; JNK2; Nonalcoholic fatty liver disease; Palmitic acid; Rapamycin; SP600125

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; AUTOPHAGY PROTEIN 5; BECLIN 1; FATTY ACID; LIPOCORTIN 5; OLEIC ACID; PALMITIC ACID; RAPAMYCIN; UNSATURATED FATTY ACID; APOPTOSIS REGULATORY PROTEIN; ATG5 PROTEIN, HUMAN; BECN1 PROTEIN, HUMAN; MAP1LC3 PROTEIN, MOUSE; MAP1LC3A PROTEIN, HUMAN; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 9; PROTEIN KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; LIPID DIET; LIPOTOXICITY; LIVER CELL; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; HEPG2 CELL LINE; METABOLISM; NON-ALCOHOLIC FATTY LIVER DISEASE; PATHOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HEP G2 CELLS; HEPATOCYTES; HUMANS; MEMBRANE PROTEINS; MICE, INBRED C57BL; MICROTUBULE-ASSOCIATED PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; NON-ALCOHOLIC FATTY LIVER DISEASE; PALMITIC ACID; PROTEIN KINASE INHIBITORS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 84898725533     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2013.170     Document Type: Article

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