Myocardial lipid accumulation in patients with pressure-overloaded heart and metabolic syndrome

Journal of Lipid Research

Volumn 50, Issue 11, 2009, Pages 2314-2323

  Marfella, Raffaele ^a   Di Filippo, Clara ^a   Portoghese, Michele ^b   Barbieri, Michelangela ^a   Ferraraccio, Franca ^a   Siniscalchi, Mario ^a   Cacciapuoti, Federico ^a   Rossi, Francesco ^a   D'Amico, Michele ^a   Paolisso, Giuseppe ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b Sassari Hospital   (Italy)

Author keywords

Aortic stenosis; Heart function; Surgery

Indexed keywords

LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C;

AGED; AORTA VALVE REGURGITATION; ARTICLE; CONTROLLED STUDY; FEMALE; HEART EJECTION FRACTION; HEART MUSCLE CELL; HEART VENTRICLE OVERLOAD; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIPID STORAGE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FUNCTION; WESTERN BLOTTING;

AGED; AORTIC VALVE STENOSIS; BLOTTING, WESTERN; ECHOCARDIOGRAPHY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LIPID METABOLISM; LIPIDS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MYOCARDIUM; PPAR GAMMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 70350349875     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.P900032-JLR200     Document Type: Article

References (30)

1. Burchfiel, C. M., T. N. Skelton, M. E. Andrew, R. J. Garrison, D. K. Arnett, D. W. Jones, and H. A. Taylor Jr. 2005. Metabolic syndrome and echocardiographic left ventricular mass in blacks: the Atherosclerosis Risk in Communities (ARIC) Study. Circulation. 112: 819-827.
2. McGavock, J. M., R. G. Victor, R. H. Unger, and L. S. Szczepaniak. 2006. Adiposity of the heart, revisited. Ann. Intern. Med. 144: 517-524.
3. McGavock, J. M., I. Lingvay, I. Zib, T. Tillery, N. Salas, R. Unger, B. D. Levine, P. Raskin, R. G. Victor, and L. S. Szczepaniak. 2007. Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study. Circulation. 116: 1170-1175.
4. Zhou, Y. T., P. Grayburn, A. Karim, M. Shimabukuro, M. Higa, D. Baetens, L. Orci, and R. H. Unger. 2000. Lipotoxic heart disease in obese rats: implications for human obesity. Proc. Natl. Acad. Sci. USA. 97: 1784-1789.
5. Chiu, H. C., A. Kovacs, D. A. Ford, F. F. Hsu, R. Garcia, and P. Herrero. 2001. A novel mouse model of lipotoxic cardiomyopathy. J. Clin. Invest. 107: 813-822.
6. Sharma, S., J. V. Adrogue, L. Golfman, I. Uray, J. Lemm, K. Youker, G. P. Noon, O. H. Frazier, and H. Taegtmeyer. 2004. Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart. FASEB J. 18: 1692-1700.
7. Rosen, E. D., C. J. Walkey, P. Puigserver, and B. M. Spiegelman. 2000. Transcriptional regulation of adipogenesis. Genes Dev. 14: 1293-1307.
8. Tontonoz, P., J. B. Kim, R. A. Graves, and B. M. Spiegelman. 1993. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol. Cell. Biol. 13: 4753-4759.
9. Muller-Wieland, D., and J. Kotzka. 2002. SREBP-1: gene regulatory key to syndrome X? Ann. N. Y. Acad. Sci. 967: 19-27.
10. Fajas, L., K. Schoonjans, L. Gelman, J. B. Kim, J. Najib, and G. Martin. 1999. Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/ sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol. Cell. Biol. 19: 5495-5503.
11. Opie, L. H., P. J. Commerford, B. J. Gersh, and M. A. Pfeffer. 2006. Controversies in ventricular remodelling. Lancet. 367: 356-367.
12. WHO. Definition of metabolic syndrome in definition, diagnosis and classification of diabetes and its complications. Report of a WHO consultation. Part 1: Diagnosis and classification of diabetes mellitus. WHO/NCD/NCS/99.2. 1999. Geneve, World Health Organization-Department of Noncommunicable Disease Surveillance.
13. Matthews, D. R., J. P. Hosker, A. S. Rudenski, B. A. Naylor, D. F. Treacher, and R. C. Turner. 1985. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28: 412-419.
14. Gardin, J. M., D. B. Adams, P. S. Douglas, H. Feigenbaum, D. H. Forst, and A. G. Fraser. 2002. Recommendations for a standardized report for adult transthoracic echocardiography: a report from the American Society of Echocardiography's Nomenclature and Standards Committee and Task Force for a Standardized Echocardiography Report. J. Am. Soc. Echocardiogr. 15: 275-290.
15. Marfella, R., M. Siniscalchi, K. Esposito, A. Sellitto, U. De Fanis, C. Romano, M. Portoghese, S. Siciliano, F. Nappo, F. C. Sasso, et al. 2003. Effects of stress hyperglycemia on acute myocardial infarction: role of inflammatory immune process in functional cardiac outcome. Diabetes Care. 26: 3129-3135.
16. Mihara, M., and M. Uchiyama. 1978. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal. Biochem. 86: 271-278.
17. Marfella, R., K. Esposito, F. Nappo, M. Siniscalchi, F. C. Sasso, M. Portoghese, M. P. Di Marino, A. Baldi, S. Cuzzocrea, C. Di Filippo, et al. 2004. Expression of angiogenic factors during acute coronary syndromes in human type 2 diabetes. Diabetes. 53: 2383-2391.
18. Barrans, J. D., P. D. Allen, D. Stamatiou, V. J. Dzau, and C. C. Liew. 2002. Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray. Am. J. Pathol. 160: 2035-2043.
19. Young, M. E., P. McNulty, and H. Taegtmeyer. 2002. Adaptation and maladaptation of the heart in diabetes: Part II: potential mechanisms. Circulation. 105: 1861-1870.
20. Mingrone, G., G. Rosa, A. V. Greco, M. Manco, N. Vega, M. K. Hesselink, M. Castagneto, P. Schrauwen, and H. Vidal. 2003. Intramyocitic lipid accumulation and SREBP-1c expression are related to insulin resistance and cardiovascular risk in morbid obesity. Atherosclerosis. 170: 155-161.
21. Roche, H. M., C. Phillips, and M. J. Gibney. 2005. The metabolic syndrome: the crossroads of diet and genetics. Proc. Nutr. Soc. 64: 371-377.
22. Biddinger, S. B., K. Almind, M. Miyazaki, E. Kokkotou, J. M. Ntambi, and C. R. Kahn. 2005. Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes. 54: 1314-1323.
23. Horton, J. D., I. Shimomura, S. Ikemoto, Y. Bashmakov, and R. E. Hammer. 2003. Overexpression of sterol regulatory element-binding ptotein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver. J. Biol. Chem. 278: 3665-36660.
24. Schadinger, S. E., N. L. Bucher, B. M. Schreiber, and S. R. Farmer. 2005. PPARgamma regulates lipogenesis and lipid accumulation in steatotic hepatocytes. Am. J. Physiol. Endocrinol. Metab. 288: E1195-E1205.
25. Zhang, Y. L., A. Hernandez-Ono, P. Siri, S. Weisberg, D. Conlon, M. J. Graham, R. M. Crooke, L. S. Huang, and H. N. Ginsberg. 2006. Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis. J. Biol. Chem. 281: 37603-37615.
26. Son, N. H., T. S. Park, H. Yamashita, M. Yokoyama, L. A. Huggins, K. Okajima, S. Homma, M. J. Szabolcs, L. S. Huang, and I. J. Goldberg. 2007. Cardiomyocyte expression of PPAR leads to cardiac dysfunction in mice. J. Clin. Invest. 117: 2791-2801.
27. Hong, K. M., J. B. Belperio, M. P. Keane, M. D. Burdick, and R. M. Strieter. 2007. Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator activated receptor-gamma. J. Biol. Chem. 282: 22910-22920.
28. Unger, R. H. 2008. Reinventing type 2 diabetes pathogenesis, treatment, and prevention. JAMA. 299: 1185-1187.
29. Marfella, R., M. Barbieri, and G. Paolisso. 2008. Insulin therapy and lipid overload in type 2 diabetes. JAMA. 300: 789-790.
30. Yang, J., N. Sambandam, X. Han, R. W. Gross, M. Courtois, A. Kovacs, M. Febbraio, B. N. Finck, and D. P. Kelly. 2007. CD36 deficiency rescues lipotoxic cardiomyopathy. Circ. Res. 100: 1208-1217.