Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death

Basic Research in Cardiology

Volumn 109, Issue 6, 2014, Pages

  Nabben, Miranda ^a,b   van Bree, Bianca W J ^a   Lenaers, Ellen ^a   Hoeks, Joris ^a   Hesselink, Matthijs K C ^a   Schaart, Gert ^a   Gijbels, Marion J J ^c   Glatz, Jan F C ^c   da Silva, Gustavo J J ^c   de Windt, Leon J ^c   Tian, Rong ^b   Mike, Elise ^d   Skapura, Darlene G ^d   Wehrens, Xander H T ^d   Schrauwen, Patrick ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF WASHINGTON   (United States)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Arrhythmia; Metabolism; Mitochondria; Muscle; Uncoupling protein

Indexed keywords

BIOLOGICAL MARKER; ETOMOXIR; ISOPRENALINE; UNCOUPLING PROTEIN 3; ION CHANNEL; LIPID; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 3;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CARDIAC REMODELING; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; ECHOCARDIOGRAPHY; FIBROSIS; HEART; HEART ELECTROPHYSIOLOGY; HEART FUNCTION; HEART PACING; HEART VENTRICLE TACHYCARDIA; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIPID ANALYSIS; LIPOTOXICITY; MALE; MOUSE; MUSCLE METABOLISM; MUSCLE MITOCHONDRION; NONHUMAN; PROTEIN FUNCTION; QRS INTERVAL; QTC INTERVAL; RESPIROMETRY; SKELETAL MUSCLE; SUDDEN CARDIAC DEATH; ANIMAL; C57BL MOUSE; DEATH, SUDDEN, CARDIAC; DEFICIENCY; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY; ULTRASTRUCTURE;

ANIMALS; DEATH, SUDDEN, CARDIAC; ION CHANNELS; LIPIDS; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, MUSCLE; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; OXIDATION-REDUCTION;

EID: 84928437190     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-014-0447-4     Document Type: Article

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