Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A

Nucleic Acids Research

Volumn 43, Issue 20, 2015, Pages 10015-10025

  Kaminishi, Tatsuya ^a   Schedlbauer, Andreas ^a   Fabbretti, Attilio ^b   Brandi, Letizia ^b   Ochoa Lizarralde, Borja ^a   He, Cheng Guang ^b   Milón, Pohl ^c   Connell, Sean R ^a,d   Gualerzi, Claudio O ^b   Fucini, Paola ^a,d  

^a CIC BIOGUNE   (Spain)

^b UNIVERSITY OF CAMERINO   (Italy)

^c UNIVERSIDAD PERUANA DE CIENCIAS APLICADAS   (Peru)

^d BASQUE FOUNDATION FOR SCIENCE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HYGROMYCIN; PEPTIDYLTRANSFERASE; TRANSFER RNA; AMINOACYL TRANSFER RNA; CINNAMIC ACID DERIVATIVE; HYGROMYCIN B; PROTEIN SYNTHESIS INHIBITOR;

3' UNTRANSLATED REGION; ANTIBACTERIAL ACTIVITY; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RNA BINDING; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; ANALOGS AND DERIVATIVES; BINDING SITE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; LARGE RIBOSOMAL SUBUNIT; METABOLISM; MOLECULAR MODEL;

BINDING SITES; CINNAMATES; CRYSTALLOGRAPHY, X-RAY; HYGROMYCIN B; MODELS, MOLECULAR; PEPTIDYL TRANSFERASES; PROTEIN SYNTHESIS INHIBITORS; RIBOSOME SUBUNITS, LARGE, BACTERIAL; RNA, TRANSFER, AMINO ACYL;

EID: 84951777990     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkv975     Document Type: Article

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