Complement component c5a primes retinal pigment epithelial cells for inflammasome activation by lipofuscin-mediated photooxidative damage

Journal of Biological Chemistry

Volumn 290, Issue 52, 2015, Pages 31189-31198

  Brandstetter, Carolina ^a   Holz, Frank G ^a   Krohne, Tim U ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; BODY FLUIDS; CELLS; CYTOLOGY; OPHTHALMOLOGY; PATHOLOGY;

AGE-RELATED MACULAR DEGENERATION; COMPLEMENT ACTIVATIONS; CONDITIONED MEDIUM; LYSOSOMAL MEMBRANES; PHOTOOXIDATIVE DAMAGE; RETINAL PIGMENT EPITHELIAL CELLS; RETINAL PIGMENT EPITHELIUM; THERAPEUTIC TARGETS;

CHEMICAL ACTIVATION;

COMPLEMENT; COMPLEMENT COMPONENT C5A; INFLAMMASOME; INTERLEUKIN 1 RECEPTOR; PROTEIN C3AR; PROTEIN C5AR; UNCLASSIFIED DRUG; CARRIER PROTEIN; CRYOPYRIN; IL1B PROTEIN, HUMAN; INTERLEUKIN 1BETA; LIPOFUSCIN; NLRP3 PROTEIN, HUMAN;

AGE RELATED MACULAR DEGENERATION; ARTICLE; BIOACCUMULATION; BLOOD ANALYSIS; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FETUS; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PATHOGENESIS; PHOTOOXIDATION; PIGMENT EPITHELIUM; PRIMARY CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; UPREGULATION; CELL LINE; EPITHELIUM CELL; MACULAR DEGENERATION; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; RETINAL PIGMENT EPITHELIUM;

CARRIER PROTEINS; CELL LINE; COMPLEMENT C5A; EPITHELIAL CELLS; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; LIPOFUSCIN; MACULAR DEGENERATION; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; OXIDATION-REDUCTION; RETINAL PIGMENT EPITHELIUM;

EID: 84951746392     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.671180     Document Type: Article

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