ZT-25, a new vacuolar H+-ATPase inhibitor, induces apoptosis and protective autophagy through ROS generation in HepG2 cells

European Journal of Pharmacology

Volumn 771, Issue , 2016, Pages 130-138

  Lu, Yapeng ^a,b   Zhang, Rui ^c   Liu, Siyuan ^b   Zhao, Yu ^b   Gao, Jing ^a   Zhu, Li ^b  

^a JIANGSU UNIVERSITY   (China)

^b NANTONG UNIVERSITY   (China)

^c Department of Neurology   (China)

Author keywords

Apoptosis; Autophagy; Diphyllin glycosi dederivatives; Reactive oxygen species; Vacuolar H+ ATPase

Indexed keywords

3 METHYLADENINE; ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATASE INHIBITOR; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; BECLIN 1; BENZYLOXYCARBONYL (CBZ) LEUCYLVALYLALANYLASPARTYL (OME) FLUOROMETHYLKETONE; CASPASE 3; CASPASE INHIBITOR; CHLOROQUINE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ZT 25; 1,3 BENZODIOXOLE DERIVATIVE; ENZYME INHIBITOR; GLYCOSIDE; MATRIX METALLOPROTEINASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; ZT-25 COMPOUND;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL CYCLE G0 PHASE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENTIATION; G1 PHASE CELL CYCLE CHECKPOINT; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; CELL CYCLE; DRUG EFFECTS; HEP-G2 CELL LINE; METABOLISM; MITOSIS; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; APOPTOSIS; AUTOPHAGY; BENZODIOXOLES; CELL CYCLE; CELL LINE, TUMOR; ENZYME INHIBITORS; GLYCOSIDES; HEP G2 CELLS; HUMANS; MATRIX METALLOPROTEINASES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOSIS; REACTIVE OXYGEN SPECIES; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84951309908     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.12.026     Document Type: Article

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