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Volumn 75, Issue 18, 2015, Pages 3946-3957

Heparanase enhances tumor growth and chemoresistance by promoting autophagy

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; HEPARANASE; HEPARANASE INHIBITOR; PG 545; UNCLASSIFIED DRUG; AMINO ACID; ANTINEOPLASTIC AGENT; BETA GLUCURONIDASE; CISPLATIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MEMBRANE LIPID; MULTIPROTEIN COMPLEX; PHOSPHATIDYLETHANOLAMINE; TARGET OF RAPAMYCIN KINASE; TUMOR PROTEIN;

EID: 84942907310     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-0037     Document Type: Article
Times cited : (131)

References (53)
  • 1
    • 77956624954 scopus 로고    scopus 로고
    • Proteoglycans in health and disease: New concepts for heparanase function in tumor progression and metastasis
    • Barash U, Cohen-Kaplan V, Dowek I, Sanderson RD, Ilan N, Vlodavsky I. Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis. FEBS J 2010;277:3890-903.
    • (2010) FEBS J , vol.277 , pp. 3890-3903
    • Barash, U.1    Cohen-Kaplan, V.2    Dowek, I.3    Sanderson, R.D.4    Ilan, N.5    Vlodavsky, I.6
  • 2
    • 33748683743 scopus 로고    scopus 로고
    • Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis
    • Ilan N, Elkin M, Vlodavsky I. Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis. Intl J Biochem Cell Biol 2006;38:2018-39.
    • (2006) Intl J Biochem Cell Biol , vol.38 , pp. 2018-2039
    • Ilan, N.1    Elkin, M.2    Vlodavsky, I.3
  • 3
  • 4
    • 0034904048 scopus 로고    scopus 로고
    • Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis
    • Vlodavsky I, Friedmann Y. Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis. J Clin Invest 2001;108:341-7.
    • (2001) J Clin Invest , vol.108 , pp. 341-347
    • Vlodavsky, I.1    Friedmann, Y.2
  • 6
    • 0023831047 scopus 로고
    • A heparin-binding angiogenic protein-basic fibroblast growth factor-is stored within basement membrane
    • Folkman J, Klagsbrun M, Sasse J, Wadzinski M, Ingber D, Vlodavsky I. A heparin-binding angiogenic protein-basic fibroblast growth factor-is stored within basement membrane. Am J Pathol 1988;130:393-400.
    • (1988) Am J Pathol , vol.130 , pp. 393-400
    • Folkman, J.1    Klagsbrun, M.2    Sasse, J.3    Wadzinski, M.4    Ingber, D.5    Vlodavsky, I.6
  • 8
    • 20144376911 scopus 로고    scopus 로고
    • Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase
    • Levy-Adam F, Abboud-Jarrous G, Guerrini M, Beccati D, Vlodavsky I, Ilan N. Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase. J Biol Chem 2005;280:20457-66.
    • (2005) J Biol Chem , vol.280 , pp. 20457-20466
    • Levy-Adam, F.1    Abboud-Jarrous, G.2    Guerrini, M.3    Beccati, D.4    Vlodavsky, I.5    Ilan, N.6
  • 9
    • 0037092519 scopus 로고    scopus 로고
    • Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts
    • Nadav L, Eldor A, Yacoby-Zeevi O, Zamir E, Pecker I, Ilan N, et al. Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts. J Cell Sci 2002;115:2179-87.
    • (2002) J Cell Sci , vol.115 , pp. 2179-2187
    • Nadav, L.1    Eldor, A.2    Yacoby-Zeevi, O.3    Zamir, E.4    Pecker, I.5    Ilan, N.6
  • 10
    • 84925286076 scopus 로고    scopus 로고
    • Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and alpha-actinin
    • Shteingauz A, Ilan N, Vlodavsky I. Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and alpha-actinin. Cell Mol Life Sci 2014;71:4457-70.
    • (2014) Cell Mol Life Sci , vol.71 , pp. 4457-4470
    • Shteingauz, A.1    Ilan, N.2    Vlodavsky, I.3
  • 13
    • 17644427328 scopus 로고    scopus 로고
    • Heparanase processing by lysosomal/endosomal protein preparation
    • Cohen E, Atzmon R, Vlodavsky I, Ilan N. Heparanase processing by lysosomal/endosomal protein preparation. FEBS Lett 2005;579:2334-8.
    • (2005) FEBS Lett , vol.579 , pp. 2334-2338
    • Cohen, E.1    Atzmon, R.2    Vlodavsky, I.3    Ilan, N.4
  • 14
    • 49649094763 scopus 로고    scopus 로고
    • Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment
    • Abboud-Jarrous G, Atzmon R, Peretz T, Palermo C, Gadea BB, Joyce JA, et al. Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment. J Biol Chem 2008;283:18167-76.
    • (2008) J Biol Chem , vol.283 , pp. 18167-18176
    • Abboud-Jarrous, G.1    Atzmon, R.2    Peretz, T.3    Palermo, C.4    Gadea, B.B.5    Joyce, J.A.6
  • 17
    • 2542494203 scopus 로고    scopus 로고
    • Heparanase induces endothelial cell migration via protein kinase B/Akt activation
    • Gingis-Velitski S, Zetser A, Flugelman MY, Vlodavsky I, Ilan N. Heparanase induces endothelial cell migration via protein kinase B/Akt activation. J Biol Chem 2004;279:23536-41.
    • (2004) J Biol Chem , vol.279 , pp. 23536-23541
    • Gingis-Velitski, S.1    Zetser, A.2    Flugelman, M.Y.3    Vlodavsky, I.4    Ilan, N.5
  • 18
    • 0035915452 scopus 로고    scopus 로고
    • Internalization and stepwise degradation of heparan sulfate proteoglycans in rat hepatocytes
    • Egeberg M, Kjeken R, Kolset SO, Berg T, Prydz K. Internalization and stepwise degradation of heparan sulfate proteoglycans in rat hepatocytes. Biochim Biophys Acta 2001;1541:135-49.
    • (2001) Biochim Biophys Acta , vol.1541 , pp. 135-149
    • Egeberg, M.1    Kjeken, R.2    Kolset, S.O.3    Berg, T.4    Prydz, K.5
  • 19
    • 79957883170 scopus 로고    scopus 로고
    • The multiple roles of autophagy in cancer
    • Rosenfeldt MT, Ryan KM. The multiple roles of autophagy in cancer. Carcinogenesis 2011;32:955-63.
    • (2011) Carcinogenesis , vol.32 , pp. 955-963
    • Rosenfeldt, M.T.1    Ryan, K.M.2
  • 20
    • 84861526009 scopus 로고    scopus 로고
    • Deconvoluting the context-dependent role for autophagy in cancer
    • White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 2012;12:401-10.
    • (2012) Nat Rev Cancer , vol.12 , pp. 401-410
    • White, E.1
  • 21
    • 78649742684 scopus 로고    scopus 로고
    • Post-transcriptional regulation of heparanase gene expression by a 30 AU-rich element
    • Arvatz G, Barash U, Nativ O, Ilan N, Vlodavsky I. Post-transcriptional regulation of heparanase gene expression by a 30 AU-rich element. FASEB J 2011;24:4969-76.
    • (2011) FASEB J , vol.24 , pp. 4969-4976
    • Arvatz, G.1    Barash, U.2    Nativ, O.3    Ilan, N.4    Vlodavsky, I.5
  • 22
    • 57749114628 scopus 로고    scopus 로고
    • Heparanase augments epidermal growth factor receptor phosphorylation: Correlation with head and neck tumor progression
    • Cohen-Kaplan V, Doweck I, Naroditsky I, Vlodavsky I, Ilan N. Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression. Cancer Res 2008;68:10077-85.
    • (2008) Cancer Res , vol.68 , pp. 10077-10085
    • Cohen-Kaplan, V.1    Doweck, I.2    Naroditsky, I.3    Vlodavsky, I.4    Ilan, N.5
  • 23
    • 84857477759 scopus 로고    scopus 로고
    • Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: Preclinical and clinical significance in head and neck cancer
    • Cohen-Kaplan V, Jrbashyan J, Yanir Y, Naroditsky I, Ben-Izhak O, Ilan N, et al. Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancer. J Biol Chem 2012;287:6668-78.
    • (2012) J Biol Chem , vol.287 , pp. 6668-6678
    • Cohen-Kaplan, V.1    Jrbashyan, J.2    Yanir, Y.3    Naroditsky, I.4    Ben-Izhak, O.5    Ilan, N.6
  • 24
    • 34548019442 scopus 로고    scopus 로고
    • Syk tyrosine kinase is linked to cell motility and progression in squamous cell carcinomas of the head and neck
    • Luangdilok S, Box C, Patterson L, Court W, Harrington K, Pitkin L, et al. Syk tyrosine kinase is linked to cell motility and progression in squamous cell carcinomas of the head and neck. Cancer Res 2007;67:7907-16.
    • (2007) Cancer Res , vol.67 , pp. 7907-7916
    • Luangdilok, S.1    Box, C.2    Patterson, L.3    Court, W.4    Harrington, K.5    Pitkin, L.6
  • 25
    • 65249103282 scopus 로고    scopus 로고
    • Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases
    • Zcharia E, Jia J, Zhang X, Baraz L, Lindahl U, Peretz T, et al. Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases. PloS One 2009;4:e5181.
    • (2009) PloS One , vol.4 , pp. e5181
    • Zcharia, E.1    Jia, J.2    Zhang, X.3    Baraz, L.4    Lindahl, U.5    Peretz, T.6
  • 26
    • 79951676056 scopus 로고    scopus 로고
    • PG545, a dual heparanase and angiogenesis inhibitor, induces potent antitumour and anti-metastatic efficacy in preclinical models
    • Dredge K, Hammond E, Handley P, Gonda TJ, Smith MT, Vincent C, et al. PG545, a dual heparanase and angiogenesis inhibitor, induces potent antitumour and anti-metastatic efficacy in preclinical models. Br J Cancer 2011;104:635-42.
    • (2011) Br J Cancer , vol.104 , pp. 635-642
    • Dredge, K.1    Hammond, E.2    Handley, P.3    Gonda, T.J.4    Smith, M.T.5    Vincent, C.6
  • 27
    • 84922329456 scopus 로고    scopus 로고
    • Heparanase enhances myeloma progression via CXCL10 downregulation
    • Barash U, Zohar Y, Wildbaum G, Beider K, Nagler A, Karin N, et al. Heparanase enhances myeloma progression via CXCL10 downregulation. Leukemia 2014;28:2178-87.
    • (2014) Leukemia , vol.28 , pp. 2178-2187
    • Barash, U.1    Zohar, Y.2    Wildbaum, G.3    Beider, K.4    Nagler, A.5    Karin, N.6
  • 28
    • 77951628417 scopus 로고    scopus 로고
    • A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics
    • Barash U, Cohen-Kaplan V, Arvatz G, Gingis-Velitski S, Levy-Adam F, Nativ O, et al. A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics. FASEB J 2010;24:1239-48.
    • (2010) FASEB J , vol.24 , pp. 1239-1248
    • Barash, U.1    Cohen-Kaplan, V.2    Arvatz, G.3    Gingis-Velitski, S.4    Levy-Adam, F.5    Nativ, O.6
  • 29
    • 10744232455 scopus 로고    scopus 로고
    • Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior
    • Zcharia E, Metzger S, Chajek-Shaul L T, Aingorn H, Elikn M, Friedmann Y, et al. Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior. FASEB J 2004;18:252-63.
    • (2004) FASEB J , vol.18 , pp. 252-263
    • Zcharia, E.1    Metzger, S.2    Chajek-Shaul, L.T.3    Aingorn, H.4    Elikn, M.5    Friedmann, Y.6
  • 30
    • 62449097111 scopus 로고    scopus 로고
    • Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling
    • Fux L, Feibish N, Cohen-Kaplan V, Gingis-Velitski S, Feld S, Geffen C, et al. Structure-function approach identifies a COOH-terminal domain that mediates heparanase signaling. Cancer Res 2009;69:1758-67.
    • (2009) Cancer Res , vol.69 , pp. 1758-1767
    • Fux, L.1    Feibish, N.2    Cohen-Kaplan, V.3    Gingis-Velitski, S.4    Feld, S.5    Geffen, C.6
  • 31
    • 84880070907 scopus 로고    scopus 로고
    • PG545, an angiogenesis and heparanase inhibitor, reduces primary tumor growth and metastasis in experimental pancreatic cancer
    • Ostapoff KT, Awasthi N, Cenik BK, Hinz S, Dredge K, Schwarz RE, et al. PG545, an angiogenesis and heparanase inhibitor, reduces primary tumor growth and metastasis in experimental pancreatic cancer. Mol Cancer Ther 2013;12:1190-201.
    • (2013) Mol Cancer Ther , vol.12 , pp. 1190-1201
    • Ostapoff, K.T.1    Awasthi, N.2    Cenik, B.K.3    Hinz, S.4    Dredge, K.5    Schwarz, R.E.6
  • 32
  • 33
  • 34
    • 34547313009 scopus 로고    scopus 로고
    • Mammalian heparanase: What is the message?
    • Vreys V, David G. Mammalian heparanase: what is the message? J Cell Mol Med 2007;11:427-52.
    • (2007) J Cell Mol Med , vol.11 , pp. 427-452
    • Vreys, V.1    David, G.2
  • 37
    • 33845582727 scopus 로고    scopus 로고
    • Heparanase localization and expression by head and neck cancer: Correlation with tumor progression and patient survival
    • Doweck I, Kaplan-Cohen V, Naroditsky I, Sabo E, Ilan N, Vlodavsky I. Heparanase localization and expression by head and neck cancer: correlation with tumor progression and patient survival. Neoplasia 2006;8:1055-61.
    • (2006) Neoplasia , vol.8 , pp. 1055-1061
    • Doweck, I.1    Kaplan-Cohen, V.2    Naroditsky, I.3    Sabo, E.4    Ilan, N.5    Vlodavsky, I.6
  • 38
    • 32944479184 scopus 로고    scopus 로고
    • Heparanase induces vascular endothelial growth factor expression: Correlation with p38 phosphorylation levels and Src activation
    • Zetser A, Bashenko Y, Edovitsky E, Levy-Adam F, Vlodavsky I, Ilan N. Heparanase induces vascular endothelial growth factor expression: correlation with p38 phosphorylation levels and Src activation. Cancer Res 2006;66:1455-63.
    • (2006) Cancer Res , vol.66 , pp. 1455-1463
    • Zetser, A.1    Bashenko, Y.2    Edovitsky, E.3    Levy-Adam, F.4    Vlodavsky, I.5    Ilan, N.6
  • 40
  • 41
    • 84912528393 scopus 로고    scopus 로고
    • Mtor and autophagy: A dynamic relationship governed by nutrients and energy
    • Dunlop EA, Tee AR. mTOR and autophagy: A dynamic relationship governed by nutrients and energy. Semin Cell Dev Biol 2014;36:121-9.
    • (2014) Semin Cell Dev Biol , vol.36 , pp. 121-129
    • Dunlop, E.A.1    Tee, A.R.2
  • 42
    • 79956224883 scopus 로고    scopus 로고
    • Targeting autophagy during cancer therapy to improve clinical outcomes
    • Levy JM, Thorburn A. Targeting autophagy during cancer therapy to improve clinical outcomes. Pharmacol Ther 2011;131:130-41.
    • (2011) Pharmacol Ther , vol.131 , pp. 130-141
    • Levy, J.M.1    Thorburn, A.2
  • 44
    • 79961122410 scopus 로고    scopus 로고
    • Regulation of autophagy by lysosomal positioning
    • Korolchuk VI, Rubinsztein DC. Regulation of autophagy by lysosomal positioning. Autophagy 2011;7:927-8.
    • (2011) Autophagy , vol.7 , pp. 927-928
    • Korolchuk, V.I.1    Rubinsztein, D.C.2
  • 45
    • 84922789990 scopus 로고    scopus 로고
    • Nutrient-sensing mechanisms and pathways
    • Efeyan A, Comb WC, Sabatini DM. Nutrient-sensing mechanisms and pathways. Nature 2015;517:302-10.
    • (2015) Nature , vol.517 , pp. 302-310
    • Efeyan, A.1    Comb, W.C.2    Sabatini, D.M.3
  • 46
    • 84880544460 scopus 로고    scopus 로고
    • Nutrients and growth factors in mTORC1 activation
    • Efeyan A, Sabatini DM. Nutrients and growth factors in mTORC1 activation. Biochem Soc Trans 2013;41:902-5.
    • (2013) Biochem Soc Trans , vol.41 , pp. 902-905
    • Efeyan, A.1    Sabatini, D.M.2
  • 47
    • 28044442504 scopus 로고    scopus 로고
    • Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: Growth regulation and the prospect of new cancer therapies
    • Sanderson RD, Yang Y, Kelly T, Macleod V, Dai Y, Theus A. Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: Growth regulation and the prospect of new cancer therapies. J Cell Biochem 2005;96:897-905.
    • (2005) J Cell Biochem , vol.96 , pp. 897-905
    • Sanderson, R.D.1    Yang, Y.2    Kelly, T.3    Macleod, V.4    Dai, Y.5    Theus, A.6
  • 48
    • 33746552708 scopus 로고    scopus 로고
    • Development of heparanase inhibitors for anti-cancer therapy
    • Miao HQ, Liu H, Navarro E, Kussie P, Zhu Z. Development of heparanase inhibitors for anti-cancer therapy. Curr Med Chem 2006;13:2101-11.
    • (2006) Curr Med Chem , vol.13 , pp. 2101-2111
    • Miao, H.Q.1    Liu, H.2    Navarro, E.3    Kussie, P.4    Zhu, Z.5
  • 49
    • 34447287858 scopus 로고    scopus 로고
    • Heparanase: Structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate
    • Vlodavsky I, Ilan N, Naggi A, Casu B. Heparanase: structure, biological functions, and inhibition by heparin-derived mimetics of heparan sulfate. Curr Pharm Des 2007;13:2057-73.
    • (2007) Curr Pharm des , vol.13 , pp. 2057-2073
    • Vlodavsky, I.1    Ilan, N.2    Naggi, A.3    Casu, B.4
  • 50
    • 84860271832 scopus 로고    scopus 로고
    • Discovery of PG545: A highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasis
    • Ferro V, Liu L, Johnstone KD, Wimmer N, Karoli T, Handley P, et al. Discovery of PG545: a highly potent and simultaneous inhibitor of angiogenesis, tumor growth, and metastasis. J Med Chem 2012;55:3804-13.
    • (2012) J Med Chem , vol.55 , pp. 3804-3813
    • Ferro, V.1    Liu, L.2    Johnstone, K.D.3    Wimmer, N.4    Karoli, T.5    Handley, P.6
  • 51
    • 84964694241 scopus 로고    scopus 로고
    • Heparanase mediates a novel mechanism in lapatinib-resistant brain metastatic breast cancer
    • Zhang L, Ngo JA, Wetzel MD, Marchetti D. Heparanase mediates a novel mechanism in lapatinib-resistant brain metastatic breast cancer. Neoplasia 2015;17:101-13.
    • (2015) Neoplasia , vol.17 , pp. 101-113
    • Zhang, L.1    Ngo, J.A.2    Wetzel, M.D.3    Marchetti, D.4
  • 53
    • 84866325564 scopus 로고    scopus 로고
    • Degradation of heparan sulfate proteoglycans enhances oxidized-LDL-mediated autophagy and apoptosis in human endothelial cells
    • Ding Z, Wang X, Khaidakov M, Liu S, Dai Y, Mehta JL. Degradation of heparan sulfate proteoglycans enhances oxidized-LDL-mediated autophagy and apoptosis in human endothelial cells. Biochem Biophys Res Commun 2012;426:106-11.
    • (2012) Biochem Biophys Res Commun , vol.426 , pp. 106-111
    • Ding, Z.1    Wang, X.2    Khaidakov, M.3    Liu, S.4    Dai, Y.5    Mehta, J.L.6


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