Synthesis and identification of cytotoxic diphyllin glycosides as vacuolar H+-ATPase inhibitors

European Journal of Medicinal Chemistry

Volumn 82, Issue , 2014, Pages 466-471

  Zhang, Zhitao ^a   Ma, Jinlong ^a   Zhu, Li ^a   Zhao, Yu ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Cleistanthin A; Cleistanthoside A; Inhibitor; Synthesis

Indexed keywords

ADENOSINE TRIPHOSPHATASE INHIBITOR; ANTINEOPLASTIC AGENT; CLEISTANTHIN A; CLEISTANTHOSIDE A; CLEISTANTHOSIDE A TETRAACETATE; GLYCOSIDE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG; BENZOFURAN DERIVATIVE; CLEISTANTHIN; DISACCHARIDE; ENZYME INHIBITOR; LIGNAN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; GLYCOSYLATION; HELA CELL LINE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; LYSOSOME; MCF 7 CELL LINE; PH; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HCT116 CELL LINE; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BENZOFURANS; CELL LINE, TUMOR; CELL PROLIFERATION; DISACCHARIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; GLYCOSIDES; HCT116 CELLS; HELA CELLS; HEP G2 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LIGNANS; LYSOSOMES; MCF-7 CELLS; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84902474670     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.06.002     Document Type: Article

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