The prognostic value of autophagy-related markers beclin-1 and microtubule-associated protein light chain 3B in cancers: a systematic review and meta-analysis

Tumor Biology

Volumn 35, Issue 8, 2014, Pages 7317-7326

  He, Yuyu ^a   Zhao, Xianda ^a   Subahan, Narishka Roz ^a   Fan, Lifang ^a   Gao, Jun ^b   Chen, Honglei ^a  

^a WUHAN UNIVERSITY   (China)

^b Department of Molecular Pathology   (China)

Author keywords

Autophagy; Beclin 1; Cancer; Meta analysis; Microtubule associated protein light chain 3B; Prognosis; Systematic review

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; MAP1LC3B PROTEIN, HUMAN; MEMBRANE PROTEIN; MICROTUBULE ASSOCIATED PROTEIN;

AUTOPHAGY; CHEMISTRY; DISEASE FREE SURVIVAL; HUMAN; META ANALYSIS; MORTALITY; NEOPLASM; PATHOLOGY; PHYSIOLOGY; PROGNOSIS;

APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; DISEASE-FREE SURVIVAL; HUMANS; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASMS; PROGNOSIS;

EID: 84922393719     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1007/s13277-014-2060-4     Document Type: Review

References (52)

1. Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med. 2013;368:651–62.
2. Choi KS. Autophagy and cancer. Exp Mol Med. 2012;44:109–20.
3. Zhao X, He Y, Chen H. Autophagic tumor stroma: mechanisms and roles in tumor growth and progression. Int J Cancer. 2013;132:1–8.
4. Sotgia F, Martinez-Outschoorn UE, Howell A, Pestell RG, Pavlides S, Lisanti MP. Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms. Annu Rev Pathol. 2012;7:423–67.
5. Rosenfeldt MT, Ryan KM. The multiple roles of autophagy in cancer. Carcinogenesis. 2011;32:955–63.
6. Sato K, Tsuchihara K, Fujii S, Sugiyama M, Goya T, Atomi Y, et al. Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 2007;67:9677–84.
7. Jin S, White E. Role of autophagy in cancer: management of metabolic stress. Autophagy. 2007;3:28–31.
8. Sun WL, Chen J, Wang YP, Zheng H. Autophagy protects breast cancer cells from epirubicin-induced apoptosis and facilitates epirubicin-resistance development. Autophagy. 2011;7:1035–44.
9. Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, et al. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev. 2007;21:1367–81.
10. Mathew R, Karp CM, Beaudoin B, Vuong N, Chen G, Chen HY, et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell. 2009;137:1062–75.
11. Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell. 2006;10:51–64.
12. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012;8:445–544.
13. Zalckvar E, Berissi H, Mizrachy L, Idelchuk Y, Koren I, Eisenstein M, et al. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from bcl-xl and induction of autophagy. EMBO Rep. 2009;10:285–92.
14. Wei Y, Sinha S, Levine B. Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation. Autophagy. 2008;4:949–51.
15. Cao Y, Klionsky DJ. Physiological functions of Atg6/beclin 1: a unique autophagy-related protein. Cell Res. 2007;17:839–49.
16. Weidberg H, Shvets E, Shpilka T, Shimron F, Shinder V, Elazar Z. LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. EMBO J. 2010;29:1792–802.
17. Tanida I, Ueno T, Kominami E. LC3 and autophagy. Methods Mol Biol. 2008;445:77–88.
18. Zhou WH, Tang F, Xu J, Wu X, Yang SB, Feng ZY, et al. Low expression of beclin 1, associated with high Bcl-xL, predicts a malignant phenotype and poor prognosis of gastric cancer. Autophagy. 2012;8:389–400.
19. Li BX, Li CY, Peng RQ, Wu XJ, Wang HY, Wan DS, et al. The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. Autophagy. 2009;5:303–6.
20. Won KY, Kim GY, Kim YW, Song JY, Lim SJ. Clinicopathologic correlation of beclin-1 and bcl-2 expression in human breast cancer. Hum Pathol. 2010;41:107–12.
21. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009;6:e1000100.
22. Wells GA. SB, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P: The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa: Ottawa Hospital Research Institute; 2000.
23. Shea BJ, Grimshaw JM, Wells GA, Boers M, Andersson N, Hamel C, et al. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol. 2007;7:10.
24. Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials. 2007;8:16.
25. Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med. 1998;17:2815–34.
26. Williamson PR, Smith CT, Hutton JL, Marson AG. Aggregate data meta-analysis with time-to-event outcomes. Stat Med. 2002;21:3337–51.
27. Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. Fixed-effect versus random-effects models. In: Introduction to meta-analysis. Chichester: Wiley; 2009. p. 77–86.
28. Chen YB, Hou JH, Feng XY, Chen S, Zhou ZW, Zhang XS, et al. Decreased expression of beclin 1 correlates with a metastatic phenotypic feature and adverse prognosis of gastric carcinomas. J Surg Oncol. 2012;105:542–7.
29. Geng QR, Xu DZ, He LJ, Lu JB, Zhou ZW, Zhan YQ, et al. Beclin-1 expression is a significant predictor of survival in patients with lymph node-positive gastric cancer. PLoS One. 2012;7:e45968.
30. Li J, Yu G, Wang J, Pan J, Liu K, Li P, et al. The expression and prognostic value of beclin 1 and PTEN in gastric carcinoma. Chin J Dig. 2012;32:170–4.
31. Yu M, Gou WF, Zhao S, Xiao LJ, Mao XY, Xing YN, et al. Beclin 1 expression is an independent prognostic factor for gastric carcinomas. Tumour Biol J Int Soc Oncodev Biol Med. 2013;34:1071–83.
32. Kim S, Jung WH, Koo JS. Differences in autophagy-related activity by molecular subtype in triple-negative breast cancer. Tumour Biol J Int Soc Oncodev Biol Med. 2012;33:1681–94.
33. Zhao H, Yang M, Zhao J, Wang J, Zhang Y, Zhang Q. High expression of LC3B is associated with progression and poor outcome in triple-negative breast cancer. Med Oncol. 2013;30:475.
34. Choi J, Jung W, Koo JS. Expression of autophagy-related markers beclin-1, light chain 3a, light chain 3b and p62 according to the molecular subtype of breast cancer. Histopathology. 2013;62:275–86.
35. Chen S: Autophagy in breast cancer patients with residual tumors after neo-adjuvant chemotherapy and its correlation with patients outcome. Fudan University 2012.
36. Chen S, Jiang YZ, Huang L, Zhou RJ, Yu KD, Liu Y, et al.: The residual tumor autophagy marker LC3B serves as a prognostic marker in local advanced breast cancer after neoadjuvant chemotherapy. Clinical cancer research: an official journal of the American Association for Cancer Research 2013.
37. Choi JH, Cho YS, Ko YH, Hong SU, Park JH, Lee MA. Absence of autophagy-related proteins expression is associated with poor prognosis in patients with colorectal adenocarcinoma. Gastroenterol Res Pract. 2014;2014:179586.
38. Koukourakis MI, Giatromanolaki A, Sivridis E, Pitiakoudis M, Gatter KC, Harris AL. Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia. Br J Cancer. 2010;103:1209–14.
39. Li BX, Zhang X. Mechanism of beclin1 as a favorable molecules marker is that beclin1 inhibits tumor proliferation and cell cycle arrest in stage iiib colon cancers. Chin J Clin. 2010;4:395–401.
40. Myung Park J, Huang S, Wu TT, Foster NR, Sinicrope FA. Prognostic impact of beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy. Cancer Biol Ther. 2013;14:100–7.
41. Nicotra G, Mercalli F, Peracchio C, Castino R, Follo C, Valente G, et al. Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas. Mod Pathol. 2010;23:937–50.
42. Huang JJ, Li HR, Huang Y, Jiang WQ, Xu RH, Huang HQ, et al. Beclin 1 expression: a predictor of prognosis in patients with extranodal natural killer T-cell lymphoma, nasal type. Autophagy. 2010;6:777–83.
43. Huang JJ, Zhu YJ, Lin TY, Jiang WQ, Huang HQ, Li ZM. Beclin 1 expression predicts favorable clinical outcome in patients with diffuse large B-cell lymphoma treated with R-CHOP. Hum Pathol. 2011;42:1459–66.
44. Dong M, Wan XB, Yuan ZY, Wei L, Fan XJ, Wang TT, et al. Low expression of beclin 1 and elevated expression of HIF-1alpha refine distant metastasis risk and predict poor prognosis of ER-positive, HER2-negative breast cancer. Med Oncol. 2013;30:355.
45. Kim KM, Yu TK, Chu HH, Park HS, Jang KY, Moon WS, et al. Expression of er stress and autophagy-related molecules in human non-small cell lung cancer and premalignant lesions. Int J Cancer. 2012;131:E362–70.
46. Xiao Y, Long C, Zhang M, Luo Y, Hu Y. Expression of beclin-1 in non-small cell lung cancer and its clinical significance. J Third Mil Med Univ. 2013;12:1271–3.
47. Zhou W, Yue C, Deng J, Hu R, Xu J, Feng L, et al. Autophagic protein beclin 1 serves as an independent positive prognostic biomarker for non-small cell lung cancer. PLoS One. 2013;8:e80338.
48. Lebovitz CB, Bortnik SB, Gorski SM. Here, there be dragons: charting autophagy-related alterations in human tumors. Clin Cancer Res. 2012;18:1214–26.
49. Altman DG, McShane LM, Sauerbrei W, Taube SE. Reporting recommendations for tumor marker prognostic studies (remark): explanation and elaboration. PLoS Med. 2012;9:e1001216.
50. Kuma A, Matsui M, Mizushima N. LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization. Autophagy. 2007;3:323–8.
51. Zhu JH, Horbinski C, Guo F, Watkins S, Uchiyama Y, Chu CT. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol. 2007;170:75–86.
52. Scarlatti F, Maffei R, Beau I, Codogno P, Ghidoni R. Role of non-canonical beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells. Cell Death Differ. 2008;15:1318–29.