Metformin inhibits the proliferation, metastasis, and cancer stem-like sphere formation in osteosarcoma MG63 cells in vitro

Tumor Biology

Volumn 36, Issue 12, 2015, Pages 9873-9883

  Chen, Xu ^a,b   Hu, Chuanzhen ^a,b   Zhang, Weibin ^a,b   Shen, Yuhui ^a,b   Wang, Jun ^a   Hu, Fangqiong ^a   Yu, Pei ^b  

^a Shanghai Institute of Orthopedics and Traumatology   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

AMPK mTOR S6 signaling pathway; Cancer stem like cells; Metastasis; Metformin; Osteosarcoma

Indexed keywords

CD133 ANTIGEN; GELATINASE A; GELATINASE B; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN KINASE B; S6 KINASE; STAGE SPECIFIC EMBRYO ANTIGEN 4; THY 1 ANTIGEN; TRANSCRIPTION FACTOR NANOG; HOMEODOMAIN PROTEIN; MMP2 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN; NANOG PROTEIN, HUMAN; PRKAA1 PROTEIN, HUMAN;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER STEM CELL; CELL DIFFERENTIATION; CELL SELF-RENEWAL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; METASTASIS INHIBITION; MIGRATION INHIBITION; OSTEOSARCOMA CELL LINE; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; CELL CYCLE; CELL MOTION; CELL PROLIFERATION; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METASTASIS; OSTEOSARCOMA; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; METFORMIN; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASTIC STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3; OSTEOSARCOMA;

EID: 84951299605     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-015-3751-1     Document Type: Article

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