메뉴 건너뛰기




Volumn 9, Issue 6, 2014, Pages 2251-2256

Effect of metformin on apoptosis, cell cycle arrest migration and invasion of A498 cells

Author keywords

Apoptosis; Invasion; Metformin; Migration; Renal cancer

Indexed keywords

CYCLIN D1; GELATINASE A; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; PROTEIN BAX; PROTEIN BCL 2;

EID: 84899700999     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2097     Document Type: Article
Times cited : (14)

References (40)
  • 1
    • 53949096956 scopus 로고    scopus 로고
    • Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma
    • Li L, Gao Y, Zhang L, Zeng J, He D and Sun Y: Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma. Cancer Lett 272: 61-69, 2008.
    • (2008) Cancer Lett , vol.272 , pp. 61-69
    • Li, L.1    Gao, Y.2    Zhang, L.3    Zeng, J.4    He, D.5    Sun, Y.6
  • 3
    • 0030931682 scopus 로고    scopus 로고
    • Natural history and therapy of metastatic renal cell carcinoma: The role of interleukin-2
    • Bukowski RM: Natural history and therapy of metastatic renal cell carcinoma: the role of interleukin-2. Cancer 80: 1198-1220, 1997.
    • (1997) Cancer , vol.80 , pp. 1198-1220
    • Bukowski, R.M.1
  • 4
    • 0028084421 scopus 로고
    • Patterns of failure following surgical resection of renal cell carcinoma: Implications for adjuvant local and systemic therapy
    • Rabinovitch RA, Zelefsky MJ, Gaynor JJ and Fuks Z: Patterns of failure following surgical resection of renal cell carcinoma: implications for adjuvant local and systemic therapy. J Clin Oncol 12: 206-212, 1994. (Pubitemid 24020641)
    • (1994) Journal of Clinical Oncology , vol.12 , Issue.1 , pp. 206-212
    • Rabinovitch, R.A.1    Zelefsky, M.J.2    Gaynor, J.J.3    Fuks, Z.4
  • 5
    • 1942455781 scopus 로고    scopus 로고
    • A systematic review of the relation between interleukin-2 schedule and outcome in patients with metastatic renal cell cancer
    • DOI 10.1016/j.ejca.2004.02.010, PII S0959804904001911
    • Baaten G, Voogd AC and Wagstaff J: A systematic review of the relation between interleukin-2 schedule and outcome in patients with metastatic renal cell cancer. Eur J Cancer 40: 1127-1144, 2004. (Pubitemid 38526331)
    • (2004) European Journal of Cancer , vol.40 , Issue.8 , pp. 1127-1144
    • Baaten, G.1    Voogd, A.C.2    Wagstaff, J.3
  • 7
    • 84884976243 scopus 로고    scopus 로고
    • Recent advances in the treatment of metastatic renal cell carcinoma
    • Abe H and Kamai T: Recent advances in the treatment of metastatic renal cell carcinoma. Int J Urol 20: 944-955, 2013.
    • (2013) Int J Urol , vol.20 , pp. 944-955
    • Abe, H.1    Kamai, T.2
  • 8
    • 0034783579 scopus 로고    scopus 로고
    • The blooming of the French lilac
    • Witters LA: The blooming of the French lilac. J Clin Invest 108: 1105-1107, 2001.
    • (2001) J Clin Invest , vol.108 , pp. 1105-1107
    • Witters, L.A.1
  • 9
    • 84859076050 scopus 로고    scopus 로고
    • Lower risk of cancer in patients on metformin in comparison with those on sulfonylurea derivatives: Results from a large population-based follow-up study
    • Ruiter R, Visser LE, van Herk-Sukel MP, et al: Lower risk of cancer in patients on metformin in comparison with those on sulfonylurea derivatives: results from a large population-based follow-up study. Diabetes Care 35: 119-124, 2012.
    • (2012) Diabetes Care , vol.35 , pp. 119-124
    • Ruiter, R.1    Visser, L.E.2    Van Herk-Sukel, M.P.3
  • 10
    • 78651451726 scopus 로고    scopus 로고
    • Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: A representative population prospective cohort study of 800,000 individuals
    • Lee MS, Hsu CC, Wahlqvist ML, Tsai HN, Chang YH and Huang YC: Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals. BMC Cancer 11: 20, 2011.
    • (2011) BMC Cancer , vol.11 , pp. 20
    • Lee, M.S.1    Hsu, C.C.2    Wahlqvist, M.L.3    Tsai, H.N.4    Chang, Y.H.5    Huang, Y.C.6
  • 11
    • 84857467120 scopus 로고    scopus 로고
    • Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153
    • Wu N, Gu C, Gu H, Hu H, Han Y and Li Q: Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153. Neoplasma 58: 482-490, 2011.
    • (2011) Neoplasma , vol.58 , pp. 482-490
    • Wu, N.1    Gu, C.2    Gu, H.3    Hu, H.4    Han, Y.5    Li, Q.6
  • 12
    • 84878561961 scopus 로고    scopus 로고
    • Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK
    • Storozhuk Y, Hopmans SN, Sanli T, et al: Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Br J Cancer 108: 2021-2032, 2013.
    • (2013) Br J Cancer , vol.108 , pp. 2021-2032
    • Storozhuk, Y.1    Hopmans, S.N.2    Sanli, T.3
  • 13
    • 84877857216 scopus 로고    scopus 로고
    • Simvastatin inhibits renal cancer cell growth and metastasis via AKT/mTOR, ERK and JAK2/STAT3 pathway
    • Fang Z, Tang Y, Fang J, et al: Simvastatin inhibits renal cancer cell growth and metastasis via AKT/mTOR, ERK and JAK2/STAT3 pathway. PloS One 8: e62823, 2013.
    • (2013) PloS One , vol.8
    • Fang, Z.1    Tang, Y.2    Fang, J.3
  • 14
    • 84882743499 scopus 로고    scopus 로고
    • Nitidine chloride inhibits renal cancer cell metastasis via suppressing AKT signaling pathway
    • Fang Z, Tang Y, Jiao W, et al: Nitidine chloride inhibits renal cancer cell metastasis via suppressing AKT signaling pathway. Food Chem Toxicol 60: 246-251, 2013.
    • (2013) Food Chem Toxicol , vol.60 , pp. 246-251
    • Fang, Z.1    Tang, Y.2    Jiao, W.3
  • 15
    • 77956401999 scopus 로고    scopus 로고
    • Metformin and other biguanides in oncology: Advancing the research agenda
    • Phila
    • Pollak M: Metformin and other biguanides in oncology: advancing the research agenda. Cancer Prev Res (Phila) 3: 1060-1065, 2010.
    • (2010) Cancer Prev Res , vol.3 , pp. 1060-1065
    • Pollak, M.1
  • 16
    • 36348950449 scopus 로고    scopus 로고
    • Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
    • DOI 10.1158/0008-5472.CAN-07-2310
    • Dowling RJ, Zakikhani M, Fantus IG, Pollak M and Sonenberg N: Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res 67: 10804-10812, 2007. (Pubitemid 350145909)
    • (2007) Cancer Research , vol.67 , Issue.22 , pp. 10804-10812
    • Dowling, R.J.O.1    Zakikhani, M.2    Fantus, I.G.3    Pollak, M.4    Sonenberg, N.5
  • 17
    • 77952116629 scopus 로고    scopus 로고
    • Metformin in cancer therapy: A new perspective for an old antidiabetic drug?
    • Ben Sahra I, Le Marchand-Brustel Y, Tanti JF and Bost F: Metformin in cancer therapy: a new perspective for an old antidiabetic drug? Mol Cancer Ther 9: 1092-1099, 2010.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1092-1099
    • Ben Sahra, I.1    Le Marchand-Brustel, Y.2    Tanti, J.F.3    Bost, F.4
  • 18
    • 84873599613 scopus 로고    scopus 로고
    • Metformin inhibits growth of hepatocellular carcinoma cells by inducing apoptosis via mitochondrion-mediated pathway
    • Xiong Y, Lu QJ, Zhao J and Wu GY: Metformin inhibits growth of hepatocellular carcinoma cells by inducing apoptosis via mitochondrion-mediated pathway. Asian Pac J Cancer Prev 13: 3275-3279, 2012.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 3275-3279
    • Xiong, Y.1    Lu, Q.J.2    Zhao, J.3    Wu, G.Y.4
  • 19
    • 67749134053 scopus 로고    scopus 로고
    • Metformin in breast cancer: Time for action
    • Goodwin PJ, Ligibel JA and Stambolic V: Metformin in breast cancer: time for action. J Clin Oncol 27: 3271-3273, 2009.
    • (2009) J Clin Oncol , vol.27 , pp. 3271-3273
    • Goodwin, P.J.1    Ligibel, J.A.2    Stambolic, V.3
  • 20
    • 42949152052 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress
    • Okoshi R, Ozaki T, Yamamoto H, et al: Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. J Biol Chem 283: 3979-3987, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 3979-3987
    • Okoshi, R.1    Ozaki, T.2    Yamamoto, H.3
  • 21
    • 79958244812 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase contributes to doxorubicin-induced cell death and apoptosis in cultured myocardial H9c2 cells
    • Chen MB, Wu XY, Gu JH, Guo QT, Shen WX and Lu PH: Activation of AMP-activated protein kinase contributes to doxorubicin-induced cell death and apoptosis in cultured myocardial H9c2 cells. Cell Biochem Biophys 60: 311-322, 2011.
    • (2011) Cell Biochem Biophys , vol.60 , pp. 311-322
    • Chen, M.B.1    Wu, X.Y.2    Gu, J.H.3    Guo, Q.T.4    Shen, W.X.5    Lu, P.H.6
  • 22
    • 84875278034 scopus 로고    scopus 로고
    • Metformin inhibits renal cell carcinoma in vitro and in vivo xenograft
    • Liu J, Li M, Song B, et al: Metformin inhibits renal cell carcinoma in vitro and in vivo xenograft. Urol Oncol 31: 264-270, 2013.
    • (2013) Urol Oncol , vol.31 , pp. 264-270
    • Liu, J.1    Li, M.2    Song, B.3
  • 23
    • 7744235176 scopus 로고    scopus 로고
    • Targeting cell cycle and apoptosis for the treatment of human malignancies
    • Senderowicz AM: Targeting cell cycle and apoptosis for the treatment of human malignancies. Curr Opin Cell Biol 16: 670-678, 2004.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 670-678
    • Senderowicz, A.M.1
  • 24
    • 33644830944 scopus 로고    scopus 로고
    • Targeting the cell cycle: A new approach to cancer therapy
    • Schwartz GK and Shah MA: Targeting the cell cycle: a new approach to cancer therapy. J Clin Oncol 23: 9408-9421, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 9408-9421
    • Schwartz, G.K.1    Shah, M.A.2
  • 25
    • 34247149015 scopus 로고    scopus 로고
    • The regulation of cyclin D1 degradation: Roles in cancer development and the potential for therapeutic invention
    • Alao JP: The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention. Mol Cancer 6: 24, 2007.
    • (2007) Mol Cancer , vol.6 , pp. 24
    • Alao, J.P.1
  • 26
    • 84879801109 scopus 로고    scopus 로고
    • Attenuation of krüppel-like factor 4 facilitates carcinogenesis by inducing g1/s phase arrest in clear cell renal cell carcinoma
    • Song E, Ma X, Li H, et al: Attenuation of krüppel-like factor 4 facilitates carcinogenesis by inducing g1/s phase arrest in clear cell renal cell carcinoma. PloS One 8: e67758, 2013.
    • (2013) PloS One , vol.8
    • Song, E.1    Ma, X.2    Li, H.3
  • 27
    • 84880049396 scopus 로고    scopus 로고
    • Human folliculin delays cell cycle progression through late S and G2/M-phases: Effect of phosphorylation and tumor associated mutations
    • Laviolette LA, Wilson J, Koller J, et al: Human folliculin delays cell cycle progression through late S and G2/M-phases: effect of phosphorylation and tumor associated mutations. PloS One 8: e66775, 2013.
    • (2013) PloS One , vol.8
    • Laviolette, L.A.1    Wilson, J.2    Koller, J.3
  • 28
    • 84864767887 scopus 로고    scopus 로고
    • Glutathione and modulation of cell apoptosis
    • Circu ML and Aw TY: Glutathione and modulation of cell apoptosis. Biochim Biophys Acta 1823: 1767-1777, 2012.
    • (2012) Biochim Biophys Acta , vol.1823 , pp. 1767-1777
    • Circu, M.L.1    Aw, T.Y.2
  • 29
    • 84873462599 scopus 로고    scopus 로고
    • The tangled circuitry of metabolism and apoptosis
    • Andersen JL and Kornbluth S: The tangled circuitry of metabolism and apoptosis. Mol Cell 49: 399-410, 2013.
    • (2013) Mol Cell , vol.49 , pp. 399-410
    • Andersen, J.L.1    Kornbluth, S.2
  • 30
    • 84880371973 scopus 로고    scopus 로고
    • Apoptosis induction in human leukemic promyelocytic HL-60 and monocytic U937 cell lines by goniothalamin
    • Petsophonsakul P, Pompimon W and Banjerdpongchai R: Apoptosis induction in human leukemic promyelocytic HL-60 and monocytic U937 cell lines by goniothalamin. Asian Pac J Cancer Prev 14: 2885-2889, 2013.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 2885-2889
    • Petsophonsakul, P.1    Pompimon, W.2    Banjerdpongchai, R.3
  • 31
    • 84866685475 scopus 로고    scopus 로고
    • Calpains, mitochondria, and apoptosis
    • Smith MA and Schnellmann RG: Calpains, mitochondria, and apoptosis. Cardiovasc Res 96: 32-37, 2012.
    • (2012) Cardiovasc Res , vol.96 , pp. 32-37
    • Smith, M.A.1    Schnellmann, R.G.2
  • 32
    • 84890909335 scopus 로고    scopus 로고
    • Control of apoptosis by the BCL-2 protein family: Implications for physiology and therapy
    • Czabotar PE, Lessene G, Strasser A and Adams JM: Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol 15: 49-63, 2014.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 49-63
    • Czabotar, P.E.1    Lessene, G.2    Strasser, A.3    Adams, J.M.4
  • 33
    • 79958845448 scopus 로고    scopus 로고
    • Anti-proliferative effects of organic extracts from root bark of Juglans Regia L. (RBJR) on MDA-MB-231 human breast cancer cells: Role of Bcl-2/Bax, caspases and Tp53
    • Hasan TN, B LG, Shafi G, Al-Hazzani AA and Alshatwi AA: Anti-proliferative effects of organic extracts from root bark of Juglans Regia L. (RBJR) on MDA-MB-231 human breast cancer cells: role of Bcl-2/Bax, caspases and Tp53. Asian Pac J Cancer Prev 12: 525-530, 2011.
    • (2011) Asian Pac J Cancer Prev , vol.12 , pp. 525-530
    • Hasan, T.N.1    B, L.G.2    Shafi, G.3    Al-Hazzani, A.A.4    Alshatwi, A.A.5
  • 34
    • 77958599007 scopus 로고    scopus 로고
    • Huaier aqueous extract inhibits proliferation of breast cancer cells by inducing apoptosis
    • Zhang N, Kong X, Yan S, Yuan C and Yang Q: Huaier aqueous extract inhibits proliferation of breast cancer cells by inducing apoptosis. Cancer Sci 101: 2375-2383, 2010.
    • (2010) Cancer Sci , vol.101 , pp. 2375-2383
    • Zhang, N.1    Kong, X.2    Yan, S.3    Yuan, C.4    Yang, Q.5
  • 35
    • 84875980153 scopus 로고    scopus 로고
    • The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) in breast cancer
    • Zhang N, Wang X, Huo Q, et al: The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) in breast cancer. J Biol Chem 288: 9396-9407, 2013.
    • (2013) J Biol Chem , vol.288 , pp. 9396-9407
    • Zhang, N.1    Wang, X.2    Huo, Q.3
  • 36
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: Opposing activities that mediate cell death
    • Youle RJ and Strasser A: The BCL-2 protein family: opposing activities that mediate cell death. Nature Rev Mol Cell Biol 9: 47-59, 2008.
    • (2008) Nature Rev Mol Cell Biol , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 37
    • 0031747428 scopus 로고    scopus 로고
    • Tumor cell contact mediated transcriptional activation of the fibroblast matrix metalloproteinase-9 gene: Involvement of multiple transcription factors including Ets and an alternating purine-pyrimidine repeat
    • DOI 10.1023/A:1006576305405
    • Himelstein BP, Lee EJ, Sato H, Seiki M and Muschel RJ: Tumor cell contact mediated transcriptional activation of the fibroblast matrix metalloproteinase-9 gene: involvement of multiple transcription factors including Ets and an alternating purine-pyrimidine repeat. Clin Exp Metastasis 16: 169-177, 1998. (Pubitemid 28252924)
    • (1998) Clinical and Experimental Metastasis , vol.16 , Issue.2 , pp. 169-177
    • Himelstein, B.P.1    Lee, E.J.2    Sato, H.3    Seiki, M.4    Muschel, R.J.5
  • 38
    • 0034798212 scopus 로고    scopus 로고
    • Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma
    • Kallakury BV, Karikehalli S, Haholu A, Sheehan CE, Azumi N and Ross JS: Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma. Clin Cancer Res 7: 3113-3119, 2001. (Pubitemid 32963832)
    • (2001) Clinical Cancer Research , vol.7 , Issue.10 , pp. 3113-3119
    • Kallakury, B.V.S.1    Karikehalli, S.2    Haholu, A.3    Sheehan, C.E.4    Azumi, N.5    Ross, J.S.6
  • 39
    • 33646532452 scopus 로고    scopus 로고
    • Costimulation of chemokine receptor signaling by matrix metalloproteinase-9 mediates enhanced migration of IFN-alpha dendritic cells
    • Hu Y and Ivashkiv LB: Costimulation of chemokine receptor signaling by matrix metalloproteinase-9 mediates enhanced migration of IFN-alpha dendritic cells. J Immunol 176: 6022-6033, 2006.
    • (2006) J Immunol , vol.176 , pp. 6022-6033
    • Hu, Y.1    Ivashkiv, L.B.2
  • 40
    • 78650424066 scopus 로고    scopus 로고
    • Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting
    • Gialeli C, Theocharis AD and Karamanos NK: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting. FEBS J 278: 16-27, 2011.
    • (2011) FEBS J , vol.278 , pp. 16-27
    • Gialeli, C.1    Theocharis, A.D.2    Karamanos, N.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.