Aging is associated with a shift of fatty metabolism toward lipogenesis

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 66 A, Issue 11, 2011, Pages 1192-1200

  Kuhla, Angela ^a   Blei, Tina ^a   Jaster, Robert ^a   Vollmar, Brigitte ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Hepatic steatosis; Nuclear receptors; Senescence

Indexed keywords

MUS;

CELL RECEPTOR; RETINOIC ACID RECEPTOR;

AGING; ANIMAL; ARTICLE; DISEASE MODEL; FATTY LIVER; FEMALE; IMMUNOHISTOCHEMISTRY; LIPOGENESIS; LIVER; METABOLISM; MOUSE; OXIDATIVE STRESS; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AGING; ANIMALS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; FATTY LIVER; FEMALE; IMMUNOHISTOCHEMISTRY; LIPOGENESIS; LIVER; MICE; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID;

EID: 80054928549     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glr124     Document Type: Article

References (37)

1. Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest. 2004;114:147-152. (Pubitemid 39071617)
2. Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313-1321. (Pubitemid 40770284)
3. Hoyumpa AM Jr., Greene HL, Dunn GD, Schenker S. Fatty liver: biochemical and clinical considerations. Am J Dig Dis. 1975;20:1142-1170.
4. Lavrovsky Y, Chatterjee B, Clark RA, Roy AK. Role of redox-regulated transcription factors in inflammation, aging and age-related diseases. Exp Gerontol. 2000;35:521-532.
5. Edwards PA, Kennedy MA, Mak PA. LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis. Vascul Pharmacol. 2002;38:249-256. (Pubitemid 36398270)
6. Repa JJ, Mangelsdorf DJ. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu Rev Cell Dev Biol. 2000;16:459-481. (Pubitemid 32037514)
7. Janowski BA, Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature. 1996;383:728-731. (Pubitemid 26360651)
8. Song C, Liao S. Cholestenoic acid is a naturally occurring ligand for liver X receptor alpha. Endocrinology. 2000;141:4180-4184.
9. Baranowski M. Biological role of liver X receptors. J Physiol Pharmacol. 2008;59(suppl 7):31-55.
10. Langmann T, Klucken J, Reil M, et al. Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages. Biochem Biophys Res Commun. 1999;257:29-33. (Pubitemid 29299042)
11. Santamarina-Fojo S, Remaley AT, Neufeld EB, Brewer HB Jr. Regulation and intracellular trafficking of the ABCA1 transporter. J Lipid Res. 2001;42:1339-1345. (Pubitemid 34007664)
12. Feng Y, Lievens J, Jacobs F, et al. Hepatocyte-specific ABCA1 transfer increases HDL cholesterol but impairs HDL function and accelerates atherosclerosis. Cardiovasc Res. 2010;88:376-385.
13. Michalik L, Auwerx J, Berger JP, et al. International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev. 2006;58:726-741. (Pubitemid 44833742)
14. Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev. 1999;20:649-688. (Pubitemid 30650602)
15. Berger J, Moller DE. The mechanisms of action of PPARs. Annu Rev Med. 2002;53:409-435. (Pubitemid 34177889)
16. Caballero B, Vega-Naredo I, Sierra V, et al. Melatonin alters cell death processes in response to age-related oxidative stress in the brain of senescence-accelerated mice. J Pineal Res. 2009;46:106-114.
17. Takeda T, Hosokawa M, Higuchi K, Hosono M, Akiguchi I, Katoh H. A novel murine model of ageing, senescence-accelerated mouse (SAM). Arch Gerontol Geriatr. 1994;19:185-192.
18. Butterfield DA, Poon HF. The senescence-accelerated prone mouse (SAMP8): a model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease. Exp Gerontol. 2005;40:774-783. (Pubitemid 41416540)
19. Ye X, Meeker HC, Kozlowski PB, et al. Pathological changes in the liver of a senescence accelerated mouse strain (SAMP8): a mouse model for the study of liver diseases. Histol Histopathol. 2004;19:1141-1151. (Pubitemid 39386772)
20. Matsugo S, Kitagawa T, Minami S, et al. Age-dependent changes in lipid peroxide levels in peripheral organs, but not in brain, in senescence- accelerated mice. Neurosci Lett. 2000;278:105-108. (Pubitemid 30009908)
21. Rebrin I, Sohal RS. Comparison of thiol redox state of mitochondria and homogenates of various tissues between two strains of mice with different longevities. Exp Gerontol. 2004;39:1513-1519. (Pubitemid 39410551)
22. Chiba Y, Shimada A, Kumagai N, et al. The senescence-accelerated mouse (SAM): a higher oxidative stress and age-dependent degenerative diseases model. Neurochem Res. 2009;34:679-687.
23. Vilà L, Roglans N, Alegret M, et al. Hypertriglyceridemia and hepatic steatosis in senescence-accelerated mouse associate to changes in lipid-related gene expression. J Gerontol A Biol Sci Med Sci. 2007;62:1219-1227. (Pubitemid 350287610)
24. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 1959;37:911-917.
25. Fulop T, Tessier D, Carpentier A. The metabolic syndrome. Pathol Biol (Paris). 2006;54:375-386. (Pubitemid 44468297)
26. Anantharaju A, Feller A, Chedid A. Aging liver. A review. Gerontology. 2002;48:343-353.
27. Dancygier H. The pathogenesis and treatment of nonalcoholic fatty liver diseases-from fatty liver to cirrhosis. Dtsch Arztebl. 2006;103:1301-1308.
28. Teramoto S, Uejima Y, Teramoto K, et al. Effect of age on alteration of glutathione metabolism following chronic cigarette smoke inhalation in mice. Lung. 1996;174:119-126. (Pubitemid 26067683)
29. Germain P, Chambon P, Eichele G, et al. International Union of Pharmacology. LXIII. Retinoid X receptors. Pharmacol Rev. 2006;58:760-772. (Pubitemid 44833744)
30. Sanal MG. The blind men 'see' the elephant-the many faces of fatty liver disease. World J Gastroenterol. 2008;14:831-844. (Pubitemid 351325022)
31. Rakhshandehroo M, Sanderson LM, Matilainen M, et al. Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling. PPAR Res. 2007;2007:26839.
32. Adams LA, Angulo P, Lindor KD. Nonalcoholic fatty liver disease. CMAJ. 2005;172:899-905. (Pubitemid 40543601)
33. Wang Y, Kurdi-Haidar B, Oram JF. LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1. J Lipid Res. 2004;45:972-980. (Pubitemid 38552869)
34. Ou J, Tu H, Shan B, et al. Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR. Proc Natl Acad Sci USA. 2001;98:6027-6032. (Pubitemid 32488187)
35. Ouvrier A, Cadet R, Vernet P, et al. LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell-specific manner. J Lipid Res. 2009;50:1766-1775.
36. Schultz JR, Tu H, Luk A, et al. Role of LXRs in control of lipogenesis. Genes Dev. 2000;14:2831-2838.
37. Collins JL, Fivush AM, Watson MA, et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem. 2002;45:1963-1966. (Pubitemid 34477709)