Redox-sensitive nanoparticles from amphiphilic cholesterol-based block copolymers for enhanced tumor intracellular release of doxorubicin

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 11, Issue 8, 2015, Pages 2071-2082

  Nguyen, Chi Thanh ^a   Tran, Thanh Huyen ^b   Amiji, Mansoor ^b   Lu, Xiuling ^a   Kasi, Rajeswari M ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Block copolymer; Cancer therapy; Cholesterol; Intracellular release; Redox sensitive nanoparticles

Indexed keywords

CELLS; CHOLESTEROL; COVALENT BONDS; CYTOTOXICITY; DISEASES; DRUG PRODUCTS; ENCAPSULATION; ENZYME ACTIVITY; NANOPARTICLES; TUMORS;

CANCER THERAPY; DRUG RELEASE KINETICS; ENCAPSULATION EFFICIENCY; HIGH DRUG LOADINGS; INTRACELLULAR RELEASE; REDOX SENSITIVES; SELF ASSEMBLED NANOPARTICLES; SEVERE COMBINED IMMUNODEFICIENCIES;

BLOCK COPOLYMERS;

AMPHOPHILE; CHOLESTEROL; COPOLYMER; DITHIOTHREITOL; DOXORUBICIN; MACROGOL; NANOCARRIER; NANOPARTICLE; POLYMETHACRYLIC ACID; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; DELAYED RELEASE FORMULATION; DISULFIDE; MACROGOL DERIVATIVE; POLYMETHACRYLIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISULFIDE BOND; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG STABILITY; DRUG SYNTHESIS; INTERNALIZATION; MALE; MOUSE; NANOENCAPSULATION; NONHUMAN; OXIDATION REDUCTION REACTION; SCID MOUSE; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; DELAYED RELEASE FORMULATION; NEOPLASMS;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CHOLESTEROL; DELAYED-ACTION PREPARATIONS; DISULFIDES; DOXORUBICIN; DRUG DELIVERY SYSTEMS; MALE; MICE, SCID; NANOPARTICLES; NEOPLASMS; OXIDATION-REDUCTION; POLYETHYLENE GLYCOLS; POLYMETHACRYLIC ACIDS;

EID: 84951105337     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2015.06.011     Document Type: Article

References (40)

1. Schroeder A., Heller D.A., Winslow M.M., Dahlman J.E., Pratt G.W., Langer R., et al. Treating metastatic cancer with nanotechnology. Nat Rev Cancer 2012, 12:39-50.
2. Duncan R. The dawning era of polymer therapeutics. Nat Rev Drug Discov 2003, 2:347-360.
3. Pear D., Karp J.M., Hong S., Farokhzad O.C., Margalit R., Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2007, 2:751-760.
4. Kwon G.S., Forrest M.L. Amphiphilic block copolymer micelles for nanoscale drug delivery. Drug Dev Res 2006, 67:15-22.
5. Sinha R., Kim G.J., Nie S., Shin D.M. Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery. Mol Cancer Ther 2006, 5:1909-1917.
6. Phillips M.A., Gran M.L., Peppas N.A. Targeted nanodelivery of drugs and diagnostics. Nano Today 2010, 5:143-159.
7. Yang B., Lv Y., Zhu J.Y., Han Y.T., Jia H.Z., Chen W.H., et al. A pH-responsive drug nanovehicle constructed by reversible attachment of cholesterol to PEGylated poly(l-lysine) via catechol-boronic acid ester formation. Acta Biomater 2014, 10:3686-3695.
8. Schmaljohann D. Thermo- and pH-responsive polymers in drug delivery. Adv Drug Deliv Rev 2006, 58:1655-1670.
9. Rijcken C.J., Soga O., Hennink W.E., van Nostrum C.F. Triggered destabilisation of polymeric micelles and vesicles by changing polymers polarity: an attractive tool for drug delivery. J Control Release 2007, 120:131-148.
10. Chen W., Yuan Y., Cheng D., Chen J., Wang L., Shuai X. Co-delivery of doxorubicin and siRNA with reduction and pH dually sensitive nanocarrier for synergistic cancer therapy. Small 2014, 10:2678-2687.
11. Mura S., Nicolas J., Couvreur P. Stimuli-responsive nanocarriers for drug delivery. Nat Mater 2013, 12:991-1003.
12. Li Y., Xiao K., Zhu W., Deng W., Lam K.S. Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers. Adv Drug Deliv Rev 2014, 66:58-73.
13. Tian H., Chen J., Chen X. Nanoparticles for gene delivery. Small 2013, 9:2034-2044.
14. Wei Wu Q.Z., Wang Jiantao, Chen Miao, Li Shuai, Lina Zaifu, Li Jianshu Tumor-targeted aggregation of pH-sensitive nanocarriers for enhanced retention and rapid intracellular drug release. Polym Chem-Uk 2014, 5:5668-5679.
15. Li S., Wu W., Xiu K., Xu F., Li Z., Li J. Doxorubicin loaded pH-responsive micelles capable of rapid intracellular drug release for potential tumor therapy. J Biomed Nanotechnol 2014, 10:1480-1489.
16. Cheng R., Feng F., Meng F., Deng C., Feijen J., Zhong Z. Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. J Control Release 2011, 152:2-12.
17. Torchilin V. Multifunctional and stimuli-sensitive pharmaceutical nanocarriers. Eur J Pharm Biopharm 2009, 71:431-444.
18. Saito G., Swanson J.A., Lee K.D. Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities. Adv Drug Deliv Rev 2003, 55:199-215.
19. Lin C., Zhong Z., Lok M.C., Jiang X., Hennink W.E., Feijen J., et al. Novel bioreducible poly(amido amine)s for highly efficient gene delivery. Bioconjug Chem 2007, 18:138-145.
20. Matsumoto S., Christie R.J., Nishiyama N., Miyata K., Ishii A., Oba M., et al. Environment-responsive block copolymer micelles with a disulfide cross-linked core for enhanced siRNA delivery. Biomacromolecules 2009, 10:119-127.
21. Kim S.H., Jeong J.H., Lee S.H., Kim S.W., Park T.G. PEG conjugated VEGF siRNA for anti-angiogenic gene therapy. J Control Release 2006, 116:123-129.
22. Read E.S., Armes S.P. Recent advances in shell cross-linked micelles. Chem Commun (Camb) 2007, 3021-3035.
23. Lee H., Mok H., Lee S., Oh Y.K., Park T.G. Target-specific intracellular delivery of siRNA using degradable hyaluronic acid nanogels. J Control Release 2007, 119:245-252.
24. Jong-Sang Park and M.-H. Seo, Positively charged poly(alpha-(omega-aminoalkyl)lycolic acid) for the delivery of a bioactive agent via tissue and cellular uptake. US patent. 2003;US 6517869 B1.
25. Heino S., Lusa S., Somerharju P., Ehnholm C., Olkkonen V.M., Ikonen E. Dissecting the role of the golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface. Proc Natl Acad Sci U S A 2000, 97:8375-8380.
26. Wan T., Zou T., Cheng S.X., Zhuo R.X. Synthesis and characterization of biodegradable cholesteryl end-capped polycarbonates. Biomacromolecules 2005, 6:524-529.
27. Nagahama K., Ueda Y., Ouchi T., Ohya Y. Exhibition of soft and tenacious characteristics based on liquid crystal formation by introduction of cholesterol groups on biodegradable lactide copolymer. Biomacromolecules 2007, 8:3938-3943.
28. Lee A.L., Venkataraman S., Sirat S.B., Gao S., Hedrick J.L., Yang Y.Y. The use of cholesterol-containing biodegradable block copolymers to exploit hydrophobic interactions for the delivery of anticancer drugs. Biomaterials 2012, 33:1921-1928.
29. Yu Y., He Y., Xu B., He Z., Zhang Y., Chen Y., et al. Self-assembled methoxy poly(ethylene glycol)-cholesterol micelles for hydrophobic drug delivery. J Pharm Sci 2013, 102:1054-1062.
30. Liu Y., Wang Y., Zhuang D., Yang J. Bionanoparticles of amphiphilic copolymers polyacrylate bearing cholesterol and ascorbate for drug delivery. J Colloid Interface Sci 2012, 377:197-206.
31. Nguyen C.T., Tran T.H., Lu X.L., Kasi R.M. Self-assembled nanoparticles from thiol functionalized liquid crystalline brush block copolymers for dual encapsulation of doxorubicin and gold nanoparticles. Polym Chem-Uk 2014, 5:2774-2783.
32. Tran T.H., Nguyen C.T., Gonzalez-Fajardo L., Hargrove D., Song D., Deshmukh P., et al. Long circulating self-assembled nanoparticles from cholesterol-containing brush-like block copolymers for improved drug delivery to tumors. Biomacromolecules 2014, 15:4363-4375.
33. Yinsong W., Lingrong L., Jian W., Zhang Q. Preparation and characterization of self-aggregated nanoparticles of cholesterol-modified O-carboxymethyl chitosan conjugates. Carbohydr Polym 2007, 69:597-606.
34. Oh I.H., Min H.S., Li L., Tran T.H., Lee Y.K., Kwon I.C., et al. Cancer cell-specific photoactivity of pheophorbide a-glycol chitosan nanoparticles for photodynamic therapy in tumor-bearing mice. Biomaterials 2013, 34:6454-6463.
35. Chen X., Conti P.S., Moats R.A. In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in brain tumor xenografts. Cancer Res 2004, 64:8009-8014.
36. Attia A.B., Yang C., Tan J.P., Gao S., Williams D.F., Hedrick J.L., et al. The effect of kinetic stability on biodistribution and anti-tumor efficacy of drug-loaded biodegradable polymeric micelles. Biomaterials 2013, 34:3132-3140.
37. Gullotti E., Yeo Y. Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery. Mol Pharm 2009, 6:1041-1051.
38. Lv S., Li M., Tang Z., Song W., Sun H., Liu H., et al. Doxorubicin-loaded amphiphilic polypeptide-based nanoparticles as an efficient drug delivery system for cancer therapy. Acta Biomater 2013, 9:9330-9342.
39. Wang X., Li J., Wang Y., Cho K.J., Kim G., Gjyrezi A., et al. HFT-T, a targeting nanoparticle, enhances specific delivery of paclitaxel to folate receptor-positive tumors. ACS Nano 2009, 3:3165-3174.
40. Kim J.H., Kim Y.S., Park K., Lee S., Nam H.Y., Min K.H., et al. Antitumor efficacy of cisplatin-loaded glycol chitosan nanoparticles in tumor-bearing mice. J Control Release 2008, 127:41-49.