Cancer cell-specific photoactivity of pheophorbide a-glycol chitosan nanoparticles for photodynamic therapy in tumor-bearing mice

Biomaterials

Volumn 34, Issue 27, 2013, Pages 6454-6463

  Oh, In hyeok ^a   Min, Hyun Su ^b   Li, Li ^a   Tran, Thanh Huyen ^a   Lee, Yong kyu ^c   Kwon, Ick Chan ^b,d   Choi, Kuiwon ^b   Kim, Kwangmeyung ^b   Huh, Kang Moo ^a  

^a Chungnam National University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

^c Chungju National University   (South Korea)

^d Korea University   (South Korea)

Author keywords

Cancer cell specific photoactivity; Glycol chitosan nanoparticles; Pheophorbide a; Photodynamic therapy; Switchable photoactivity

Indexed keywords

CHITOSAN NANOPARTICLES; ENHANCED PERMEATION AND RETENTIONS; GLYCOL CHITOSAN; PHEOPHORBIDE A; PHOTOACTIVITY; PHOTODYNAMIC THERAPY (PDT); SELF-QUENCHING EFFECT; TUMOR-SPECIFIC TARGETING;

CARDIOVASCULAR SYSTEM; CELLS; CHITOSAN; COVALENT BONDS; DISEASES; GLYCOLS; MAMMALS; NANOPARTICLES; PHOTODYNAMIC THERAPY; PHOTOSENSITIZERS;

TUMORS;

CHITOSAN; NANOPARTICLE; PHEOPHORBIDE; PHEOPHORBIDE A CONJUGATED GLYCOL CHITOSAN NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER THERAPY; CHEMICAL STRUCTURE; CIRCULATION; CONJUGATION; CYTOTOXICITY; DISULFIDE BOND; DRUG UPTAKE; FLUORESCENCE IMAGING; MALE; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL;

ANIMALS; CHITOSAN; CHLOROPHYLL; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NANOPARTICLES; NEOPLASMS; OXIDATION-REDUCTION; PHOTOCHEMOTHERAPY; RADIATION-SENSITIZING AGENTS;

MUS;

EID: 84879076619     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.05.017     Document Type: Article

References (24)

1. Dolmans D.E.J.G.J., Fukumura D., Jain R.K. Photodynamic therapy for cancer. Nat Rev Cancer 2003, 3:380-387.
2. Sun Y., Chen Z.L., Yang X.X., Huang P., Zhou X.P., Du X.X. Magnetic chitosan nanoparticles as a drug delivery system for targeting photodynamic therapy. Nanotechnology 2009, 20:135102-135109.
3. Lee S.J., Koo H., Lee D.-E., Min S., Lee S., Chen X., et al. Tumor-homing photosensitizer-conjugated glycol chitosan nanoparticles for synchronous photodynamic imaging and therapy based on cellular on/off system. Biomaterials 2011, 32:4021-4029.
4. Suzuki H., Nakai D., Seita T., Sugiyama Y. Design of a drug delivery system for targeting based on pharmacokinetic consideration. Adv Drug Deliv Rev 1996, 19:335-357.
5. Derycke A.S.L., de Witte P.A.M. Liposomes for photodynamic therapy. Adv Drug Deliv Rev 2004, 56:17-30.
6. Lukyanov A.N., Torchilin V.P. Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs. Adv Drug Deliv Rev 2004, 56:1273-1289.
7. Lee S.J., Koo H., Jeong H., Huh M.S., Choi Y., Jeong S.Y., et al. Comparative study of photosensitizer loaded and conjugated glycol chitosan nanoparticles for cancer therapy. JControl Release 2011, 152:21-29.
8. Maeda H., Sawa T., Konno T. Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS. JControl Release 2001, 74:47-61.
9. Bhatti M., Yahioglu G., Milgrom L.R., Garcia-Maya M., Chester K.A., Deonarain M.P. Targeted photodynamic therapy with multiple-loaded recombinant antibody fragments. Int J Cancer 2008, 122:1155-1163.
10. Zhao L., Kim T.-H., Huh K.M., Kim H.-W., Kim S.Y. Self-assembled photosensitizer-conjugated nanoparticles for targeted photodynamic therapy. JBiomater Appl 2012, Available from: URL:. http://www.ncbi.nlm.nih.gov/pubmed/22983021, 10.1177/0885328212459777.
11. Yoon H.Y., Koo H., Choi K.Y., Lee S.J., Kim K., Kwon I.C., et al. Tumor-targeting hyaluronic acid nanoparticles for photodynamic imaging and therapy. Biomaterials 2012, 33:3980-3989.
12. Bae B.-c., Na K. Self-quenching polysaccharide-based nanogels of pullulan/folate-photosensitizer conjugates for photodynamic therapy. Biomaterials 2010, 31:6325-6335.
13. Bae B.C., Li F., Ling D., Na K. Self-organized nanogel from pullulan/pheophorbide-A conjugate as a macromolecular photodynamic agent. JPorphyr Phthalocyanines 2010, 14:851-858.
14. Li L., Bae B.-c., Tran T.H., Yoon K.H., Na K., Huh K.M. Self-quenchable biofunctional nanoparticles of heparin-folate-photosensitizer conjugates for photodynamic therapy. Carbohydr Polym 2011, 86:708-715.
15. Park W., Park S.J., Na K. The controlled photoactivity of nanoparticles derived from ionic interactions between a water soluble polymeric photosensitizer and polysaccharide quencher. Biomaterials 2011, 32:8261-8270.
16. Tang L.-Y., Wang Y.-C., Li Y., Du J.-Z., Wang J. Shell-detachable micelles based on disulfide-linked block copolymer as potential carrier for intracellular drug delivery. Bioconjug Chem 2009, 20:1095-1099.
17. Meng F., Hennink W.E., Zhong Z. Reduction-sensitive polymers and bioconjugates for biomedical applications. Biomaterials 2009, 30:2180-2198.
18. Cheng R., Feng F., Meng F., Deng C., Feijen J., Zhong Z. Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. JControl Release 2011, 152:2-12.
19. Li F., Bae B.-c., Na K. Acetylated hyaluronic acid/photosensitizer conjugate for the preparation of nanogels with controllable phototoxicity: synthesis, characterization, autophotoquenching properties, and invitro phototoxicity against HeLa cells. Bioconjug Chem 2010, 21:1312-1320.
20. Spiller W., Kliesch H., Wöhrle D., Hackbarth S., Röder B., Schnurpfeil G. Singlet oxygen quantum yields of different photosensitizers in polar solvents and micellar solutions. JPorphyr Phthalocyanines 1998, 2:145-158.
21. Min K.H., Park K., Kim Y.-S., Bae S.M., Lee S., Jo H.G., et al. Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy. JControl Release 2008, 127:208-218.
22. Park J.H., Saravanakumar G., Kim K., Kwon I.C. Targeted delivery of low molecular drugs using chitosan and its derivatives. Adv Drug Deliv Rev 2010, 62:28-41.
23. ® and pheophorbide a, a bacteriochlorin, in photodynamic therapy of colonic cancer cells. Photochem Photobiol 2002, 75:140-148.
24. Batlle A.M. Porphyrins, porphyrias, cancer and photodynamic therapy - amodel for carcinogenesis. JPhotochem Photobiol B 1993, 20:5-22.