DJ-1 mutation decreases astroglial release of inflammatory mediators

NeuroToxicology

Volumn 52, Issue , 2016, Pages 198-203

  Ashley, A K ^a   Hinds, A I ^a   Hanneman, W H ^a   Tjalkens, R B ^a   Legare, M E ^a  

^a Veterinary Dentistry and Oral Surgery   (United States)

Author keywords

Astrocyte; DJ 1; Lipopolysaccharide; Neuroinflammation

Indexed keywords

CYCLOOXYGENASE 2; DJ 1 PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRACENE DERIVATIVE; AUTACOID; IMIDAZOLE DERIVATIVE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRILE; PARK7 PROTEIN, MOUSE; PROTEIN DEGLYCASE DJ-1; PYRAZOLANTHRONE; PYRIDINE DERIVATIVE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL ISOLATION; CONTROLLED STUDY; DJ 1 GENE; ENZYME INHIBITION; GENE FUNCTION; GENE MUTATION; GENOTYPE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; PRIMARY CELL CULTURE; SECRETION (PROCESS);

ANIMALS; ANTHRACENES; ASTROCYTES; BUTADIENES; CYCLOOXYGENASE 2; DINOPROSTONE; IMIDAZOLES; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MICE; MICE, KNOCKOUT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRILES; PRIMARY CELL CULTURE; PROTEIN DEGLYCASE DJ-1; PYRIDINES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84951002267     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2015.12.007     Document Type: Article

References (65)

1. Ahmad A.S., Ahmad M., de Brum-Fernandes A.J., Dore S. Prostaglandin EP4 receptor agonist protects against acute neurotoxicity. Brain Res. 2005, 1066:71-77.
2. Ahmad A.S., Saleem S., Ahmad M., Dore S. Prostaglandin EP1 receptor contributes to excitotoxicity and focal ischemic brain damage. Toxicol. Sci. 2006, 89:265-270.
3. Ahmad A.S., Zhuang H., Echeverria V., Dore S. Stimulation of prostaglandin EP2 receptors prevents NMDA-induced excitotoxicity. J. Neurotrauma 2006, 23:1895-1903.
4. Aleyasin H., Rousseaux M.W., Phillips M., Kim R.H., Bland R.J., Callaghan S., Slack R.S., During M.J., Mak T.W., Park D.S. The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:18748-18753.
5. Allen J.W., Mutkus L.A., Aschner M. Isolation of neonatal rat cortical astrocytes for primary cultures. Current Protocols in Toxicology 2000, John Wiley & Sons, Inc., 11-12.14.15 (chapter 12: Unit 12.4).
6. Andres-Mateos E., Perier C., Zhang L., Blanchard-Fillion B., Greco T.M., Thomas B., Ko H.S., Sasaki M., Ischiropoulos H., Przedborski S., Dawson T.M., Dawson V.L. DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:14807-14812.
7. Ashley A.K., Hanneman W.H., Katoh T., Moreno J.A., Pollack A., Tjalkens R.B., Legare M.E. Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes. Toxicol. Lett. 2009, 184:186-191.
8. Bakos J., Duncko R., Makatsori A., Pirnik Z., Kiss A., Jezova D. Prenatal immune challenge affects growth, behavior, and brain dopamine in offspring. Ann. N. Y. Acad. Sci. 2004, 1018:281-287.
9. Bandopadhyay R., Kingsbury A.E., Cookson M.R., Reid A.R., Evans I.M., Hope A.D., Pittman A.M., Lashley T., Canet-Aviles R., Miller D.W., McLendon C., Strand C., Leonard A.J., Abou-Sleiman P.M., Healy D.G., Ariga H., Wood N.W., de Silva R., Revesz T., Hardy J.A., Lees A.J. The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. Brain 2004, 127:420-430.
10. Batelli S., Invernizzi R.W., Negro A., Calcagno E., Rodilossi S., Forloni G., Albani D. The Parkinson's disease-related protein DJ-1 protects dopaminergic neurons in vivo and cultured cells from alpha-synuclein and 6-hydroxydopamine toxicity. Neurodegenerative Dis. 2015, 15(1):13-23.
11. Bertolin G., Jacoupy M., Traver S., Ferrando-Miguel R., Saint Georges T., Grenier K., Ardila-Osorio H., Muriel M.P., Takahashi H., Lees A.J., Gautier C., Guedin D., Coge F., Fon E.A., Brice A., Corti O. Parkin maintains mitochondrial levels of the protective Parkinson's disease-related enzyme 17-β hydroxysteroid dehydrogenase type 10. Cell Death Differ. 2015, 16(January).
12. Cai Z., Zeng W., Tao K., Lu F., Gao G., Yang Q. Myricitrin alleviates MPP(+)-induced mitochondrial dysfunction in a DJ-1-dependent manner in SN4741 cells. Biochem. Biophys. Res. Commun. 2015, 458(2):227-233.
13. Cai Z., Pang Y., Lin S., Rhodes P.G. Differential roles of tumor necrosis factor-alpha and interleukin-1 beta in lipopolysaccharide-induced brain injury in the neonatal rat. Brain Res. 2003, 975:37-47.
14. Carbone D.L., Popichak K.A., Moreno J.A., Safe S., Tjalkens R.B. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis. Mol. Pharmacol. 2008, 75(1):35-43.
15. Carvey P.M., Chang Q., Lipton J.W., Ling Z. Prenatal exposure to the bacteriotoxin lipopolysaccharide leads to long-term losses of dopamine neurons in offspring: a potential, new model of Parkinson's disease. Front. Biosci. 2003, 8:s826-s837.
16. Choi J., Sullards M.C., Olzmann J.A., Rees H.D., Weintraub S.T., Bostwick D.E., Gearing M., Levey A.I., Chin L.S., Li L. Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J. Biol. Chem. 2006, 281:10816-10824.
17. Chung I.Y., Benveniste E.N. Tumor necrosis factor-alpha production by astrocytes. Induction by lipopolysaccharide IFN-gamma, and IL-1 beta. J. Immunol. 1990, 144:2999-3007.
18. Daschil N., Humpel C. Nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses. Brain Res. 2014, 18(September):1581.
19. Ejima K., Nanri H., Araki M., Koji T., Shibata E., Kashimura M., Ikeda M. Expression of mitochondrial thioredoxin-dependent antioxidant protein, SP-22, in normal human and inflammatory mouse placentae. Placenta 2000, 21:847-852.
20. Esen N., Tanga F.Y., DeLeo J.A., Kielian T. Toll-like receptor 2 (TLR2) mediates astrocyte activation in response to the Gram-positive bacterium Staphylococcus aureus. J. Neurochem. 2004, 88:746-758.
21. Gayle D.A., Ling Z., Tong C., Landers T., Lipton J.W., Carvey P.M. Lipopolysaccharide (LPS)-induced dopamine cell loss in culture: roles of tumor necrosis factor-alpha, interleukin-1beta, and nitric oxide. Brain Res. Dev. Brain Res. 2002, 133(1):27-35.
22. Goswami A., Dikshit P., Mishra A., Mulherkar S., Nukina N., Jana N.R. Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction. Biochem. Biophys. Res. Commun. 2006, 342:184-190.
23. Hennis M.R., Seamans K.W., Marvin M.A., Casey B.H., Goldberg M.S. Behavioral and neurotransmitter abnormalities in mice deficient for Parkin, DJ-1 and superoxide dismutase. PLoS One 2013, 8(12):e84894.
24. Herrera A.J., Castano A., Venero J.L., Cano J., Machado A. The single intranigral injection of LPS as a new model for studying the selective effects of inflammatory reactions on dopaminergic system. Neurobiol. Dis. 2000, 7:429-447.
25. Hirotani M., Maita C., Niino M., Iguchi-Ariga S., Hamada S., Ariga H., Sasaki H. Correlation between DJ-1 levels in the cerebrospinal fluid and the progression of disabilities in multiple sclerosis patients. Mult. Scler. 2008, 14:1056-1060.
26. Hoban D.B., Connaughton E., Connaughton C., Hogan G., Thornton C., Mulcahy P., Moloney T.C., Dowd E. Further characterisation of the LPS model of Parkinson's disease: a comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat. Brain Behav. Immun. 2013, 27(1):91-100.
27. Hunter R.L., Dragicevic N., Seifert K., Choi D.Y., Liu M., Kim H.C., Cass W.A., Sullivan P.G., Bing G. Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system. J. Neurochem. 2007, 100:1375-1386.
28. Larsen K., Madsen L.B., Hoj A., Bendixen C. Porcine DJ-1: cloning of PARK7 cDNA, sequence comparison, expression analysis and chromosomal localization. Cytogenet. Genome. Res. 2007, 116:93-99.
29. Lee F.S., Peters R.T., Dang L.C., Maniatis T. MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:9319-9324.
30. Ling Z., Gayle D.A., Ma S.Y., Lipton J.W., Tong C.W., Hong J.S., Carvey P.M. In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain. Mov. Disord. 2002, 17:116-124.
31. Liu F., Zhou R., Yan H., Yin H., Wu X., Tan Y., Li L. Metabotropic glutamate receptor 5 modulates calcium oscillation and innate immune response induced by lipopolysaccharide in microglial cell. Neuroscience 2014, 281C(22):24-34.
32. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001, 25(4):402-408.
33. Lu Y., He M., Zhang Y., Xu S., Zhang L., He Y., Chen C., Liu C., Pi H., Yu Z., Zhou Z. Differential pro-inflammatory responses of astrocytes and microglia involve STAT3 activation in response to 1800MHz radiofrequency fields. PLos One 2014, 9(10).
34. Mbefo M., Fares M.B., Paleologou K., Oueslati A., Yin G., Tenreiro S., Pinto M., Outeiro T., Zweckstetter M., Masliah E., Lashuel H.A. The Parkinson's disease mutant E46K enhances alpha-synuclein phosphorylation in mammalian cell-lines, in yeast and in vivo. J. Biol. Chem. 2015, 290(February (15)):9412-9427.
35. McCullough L., Wu L., Haughey N., Liang X., Hand T., Wang Q., Breyer R.M., Andreasson K. Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. J. Neurosci. 2004, 24:257-268.
36. Meulener M.C., Graves C.L., Sampathu D.M., Armstrong-Gold C.E., Bonini N.M., Giasson B.I. DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein. J. Neurochem. 2005, 93:1524-1532.
37. Mitsumoto A., Nakagawa Y. DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin. Free Radic. Res. 2001, 35:885-893.
38. Mo J.S., Kim M.Y., Ann E.J., Hong J.A., Park H.S. DJ-1 modulates UV-induced oxidative stress signaling through the suppression of MEKK1 and cell death. Cell Death Differ. 2008, 15(16):1030-1041.
39. Moreno J.A., Sullivan K.A., Carbone D.L., Hanneman W.H., Tjalkens R.B. Manganese potentiates nuclear factor-kappaB-dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways. J. Neurosci. Res. 2008, 86(9):2028-2038.
40. Mullett S.J., Hinkle D.A. DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone. Neurobiol. Dis. 2009, 33(1):28-36.
41. Neniskyte U., Vilalta A., Brown G.C. Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis. FEBS Lett. 2014, 588(17):2952-2956.
42. Neumann M., Muller V., Gorner K., Kretzschmar H.A., Haass C., Kahle P.J. Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease. Acta Neuropathol. (Berl) 2004, 107:489-496.
43. Olzmann J.A., Brown K., Wilkinson K.D., Rees H.D., Huai Q., Ke H., Levey A.I., Li L., Chin L.S. Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function. J. Biol. Chem. 2004, 279:8506-8515.
44. Perrett R.M., Alexopoulou Z., Tofaris G.K. The endosomal pathway in Parkinson's disease. Mol. Cell. Neurosci. 2015, 19(10):1016.
45. Perry S.W., Dewhurst S., Bellizzi M.J., Gelbard H.A. Tumor necrosis factor-alpha in normal and diseased brain: conflicting effects via intraneuronal receptor crosstalk?. J. Neurovirol. 2002, 8:611-624.
46. Puschmann A. Monogenic Parkinson's disease and parkinsonism: clinical phenotypes and frequencies of known mutations. Parkinsonism Relat. Disord. 2013, 19(4):407-415.
47. Qin L., Wu X., Block M.L., Liu Y., Breese G.R., Hong J.S., Knapp D.J., Crews F.T. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 2007, 55:453-462.
48. Rousseaux M.W., Marcogliese P.C., Qu D., Hewitt S.J., Seang S., Kim R.H., Slack R.S., Schlossmacher M.G., Lagace D.C., Mak T.W., Park D.S. Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease. Proc. Natl. Acad. Sci. U. S. A. 2012, 109(39):15918-15923.
49. Saito Y., Miyasaka T., Hatsuta H., Takahashi-Niki K., Hayashi K., Mita Y., Kusano-Arai O., Iwanari H., Ariga H., Hamakubo T., Yoshida Y., Niki E., Murayama S., Ihara Y., Noguchi N. Immunostaining of oxidized DJ-1 in human and mouse brains. J. Neuropathol. Exp. Neurol. 2014, 73(7):714-728.
50. Sharif S.F., Hariri R.J., Chang V.A., Barie P.S., Wang R.S., Ghajar J.B. Human astrocyte production of tumour necrosis factor-alpha, interleukin-1 beta, and interleukin-6 following exposure to lipopolysaccharide endotoxin. Neurol. Res. 1993, 15:109-112.
51. Shendelman S., Jonason A., Martinat C., Leete T., Abeliovich A. DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation. PLoS Biol. 2004, 2:e362.
52. Stellwagen D., Malenka R.C. Synaptic scaling mediated by glial TNF-alpha. Nature 2006, 440:1054-1059.
53. Tai W., Ye X., Bao X., Zhao B., Wang X., Zhang D. Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models. Neuropharmacology 2013, 75:201-212.
54. Takadera T., Shiraishi Y., Ohyashiki T. Prostaglandin E2 induced caspase-dependent apoptosis possibly through activation of EP2 receptors in cultured hippocampal neurons. Neurochem. Int. 2004, 45:713-719.
55. Takahashi K., Taira T., Niki T., Seino C., Iguchi-Ariga S.M., Ariga H. DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor. J. Biol. Chem. 2001, 276:37556-37563.
56. Triplett J., Zhang Z., Sultana R., Cai J., Klein J.B., Büeler H., Butterfield D.A. Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson disease. J. Neurochem. 2015, 133(January (5)):750-765.
57. Vitkovic L., Bockaert J., Jacque C. Inflammatory cytokines: neuromodulators in normal brain. J. Neurochem. 2000, 74:457-471.
58. Waragai M., Wei J., Fujita M., Nakai M., Ho G.J., Masliah E., Akatsu H., Yamada T., Hashimoto M. Increased level of DJ-1 in the cerebrospinal fluids of sporadic Parkinson's disease. Biochem. Biophys. Res. Commun. 2006, 345:967-972.
59. Waragai M., Nakai M., Wei J., Fujita M., Mizuno H., Ho G., Masliah E., Akatsu H., Yokochi F., Hashimoto M. Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson's disease. Neurosci. Lett. 2007, 425:18-22.
60. Wilson M.A. The role of cysteine oxidation in DJ-1 function and dysfunction. Antioxid. Redox Signal. 2011, 15(1):111-122.
61. Yamaguchi H., Shen J. Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Mol. Neurodegener. 2007, 2(10).
62. Yanagisawa D., Kitamura Y., Inden M., Takata K., Taniguchi T., Morikawa S., Morita M., Inubushi T., Tooyama I., Taira T., Iguchi-Ariga S.M., Akaike A., Ariga H. DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. J. Cereb. Blood Flow Metab. 2008, 28(3):563-578.
63. Zhang L., Shimoji M., Thomas B., Moore D.J., Yu S.W., Marupudi N.I., Torp R., Torgner I.A., Ottersen O.P., Dawson T.M., Dawson V.L. Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis. Hum. Mol. Genet. 2005, 14:2063-2073.
64. Zhou W., Zhu M., Wilson M.A., Petsko G.A., Fink A.L. The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. J. Mol. Biol. 2006, 356:1036-1048.
65. Zonta M., Sebelin A., Gobbo S., Fellin T., Pozzan T., Carmignoto G. Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes. J. Physiol. 2003, 553:407-414.