Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction

Biochemical and Biophysical Research Communications

Volumn 342, Issue 1, 2006, Pages 184-190

  Goswami, Anand ^a   Dikshit, Priyanka ^a   Mishra, Amit ^a   Mulherkar, Shalaka ^a   Nukina, Nobuyuki ^b   Jana, Nihar Ranjan ^a  

^a NATIONAL BRAIN RESEARCH CENTRE   (India)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Huntingtin; Oxidative stress; Polyglutamine diseases; Proteasome

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; GLUTAMINE; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HUNTINGTIN; MUTANT PROTEIN; PROTEASOME;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION;

CELL DEATH; CELL LINE; GENE EXPRESSION; HSP40 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUNTINGTON DISEASE; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; ONCOGENE PROTEINS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEPTIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; SUPEROXIDE DISMUTASE; TIME FACTORS; UBIQUITIN;

ANIMALIA;

EID: 32644481227     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.01.136     Document Type: Article

References (27)

1. H.Y. Zoghbi, and H.T. Orr Glutamine repeats and neurodegeneration Annu. Rev. Neurosci. 23 2000 217 247
2. Huntington's Disease Collaborative Research Group, A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group, Cell 72 (1993) 971-983.
3. C.A. Ross Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders Neuron 35 2002 819 822
4. X. Lin, C.J. Cummings, and H.Y. Zoghbi Expanding our understanding of polyglutamine diseases through mouse models Neuron 24 1999 499 502
5. K.L. Sugars, and D.C. Rubinsztein Transcriptional abnormalities in Huntington's disease Trends Genet. 19 2003 133 238
6. J.H. Cha Transcriptional dysregulation in Huntington's disease Trends Neurosci. 23 2000 387 392
7. N.R. Jana, and N. Nukina Recent advances in understanding the pathogenesis of polyglutamine diseases: involvement of molecular chaperones and ubiquitin-proteasome pathway J. Chem. Neuroanat. 26 2003 95 101
8. N.F. Bence, R.M. Sampat, and R.R. Kopito Impairment of the ubiquitin-proteasome system by protein aggregation Science 292 2001 1552 1555
9. S.E. Browne, A.C. Bowling, U. MacGarvey, M.J. Baik, S.C. Berger, M.M.K. Muqit, E.D. Bird, and M.F. Beal Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia Ann. Neurol. 41 1997 646 653
10. S.E. Browne, R.J. Ferrante, and M.F. Beal Oxidative stress in Huntington's disease Brain Pathol. 9 1999 147 163
11. M.F. Beal, B.T. Hyman, and W. Koroshetz Do defect in mitochondrial energy metabolism underline the pathology of neurodegenerative diseases Trends Neurosci. 16 1993 125 131
12. E.P. Brouillet, B.G. Jatkins, B.T. Hyman, R.J. Ferrante, N.W. Kowall, R. Srivastava, D. Samanta-Roy, B.R. Rosen, and M.F. Beal Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid J. Neurochem. 60 1993 356 359
13. E. Brouillet, P. Hantraye, R.J. Ferrante, R. Dolon, A. Leroy-Willing, N.W. Kowall, and M.F. Beal Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreform movements in primates Proc. Natl. Acad. Sci. USA 92 1995 7105 7109
14. R.L. Albin, and J.T. Greenamyre Alternative excitotoxic hypotheses Neurology 42 1992 733 738
15. M.P. Blaustein Calcium transport and buffering in neurons Trends Neurosci. 11 1988 438 443
16. M.H. Glickman, and A. Ciechanover The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction Physiol. Rev. 82 2002 373 428
17. Q. Ding, and J.N. Keller Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins J. Neurochem. 77 2001 1010 1017
18. K. Okada, C. Wangpoengtrakul, T. Osawa, S. Toyokuni, S. Tanaka, and K. Uchida Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules J. Biol. Chem. 274 1999 23787 23793
19. V. Menendez-Benito, L.G. Verhoef, M.G. Masucci, and N.P. Dantuma Endoplasmic reticulum stress compromises the ubiquitin-proteasome system Hum. Mol. Genet. 14 2005 2787 2799
20. C.J. Cummings, M.A. Mancini, B. Antalffy, D.B. DeFranco, H.T. Orr, and H.Y. Zoghbi Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1 Nature Genet. 19 1998 148 154
21. Y. Chai, S.L. Koppenhafer, S.J. Shoesmith, M.K. Perez, and H.L. Paulson Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro Hum. Mol. Genet. 8 1999 673 682
22. N.R. Jana, E.A. Zemskov, G. Wang, and N. Nukina Altered proteasomal function due to the expression of polyglutamine expanded truncated huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release Hum. Mol. Genet. 10 2001 1049 1059
23. N.R. Jana, M. Tanaka, G. Wang, and N. Nukina Polyglutamine length-dependent interaction of Hsp70 and Hsp40 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity Hum. Mol. Genet. 9 2000 2009 2018
24. G.H. Wang, K. Mitsui, S.E. Kotliarova, A. Yamashita, Y. Nagao, S. Tokuhiro, T. Iwatsubo, I. Kanazawa, and N. Nukina Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells Neuroreport 10 1999 2435 2438
25. T. Taira, Y. Saito, T. Niki, S.M. Iguchi-Ariga, K. Takahashi, and H. Ariga DJ-1 has a role in antioxidative stress to prevent cell death EMBO Rep. 5 2004 213 218
26. A.V. Panov, C.A. Gutekunst, B.R. Leavitt, M.R. Hayden, J.R. Burke, W.J. Strittmatter, and J.T. Greenamyre Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines Nat. Neurosci. 5 2002 731 736
27. A. Sawa, G.W. Weigand, J. Cooper, R.L. Margolis, A.H. Sharp, J.F. Lawler, J.T. Greenamyre, S.H. Snyder, and C.A. Ross Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization Nat. Med. 5 1999 1194 1198