Manganese potentiates nuclear factor-κB-dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways

Journal of Neuroscience Research

Volumn 86, Issue 9, 2008, Pages 2028-2038

  Moreno, Julie A ^a   Sullivan, Kelly A ^a   Carbone, David L ^a   Hanneman, William H ^a   Tjalkens, Ronald B ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

Astrocyte; Extracellular response kinase; Inducible nitric oxide synthase; Manganese; Nuclear factor B; Soluble guanylate cyclase

Indexed keywords

CYCLIC GMP; GAMMA INTERFERON; GUANYLATE CYCLASE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MANGANESE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FLUORESCENCE; INFLAMMATION; MOUSE; NERVE CELL LESION; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CULTURE MEDIA; CYCLIC GMP; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENES, REPORTER; GUANYLATE CYCLASE; MANGANESE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 48249151836     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21640     Document Type: Article

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