Inhibition of Src tyrosine kinase activity by squamosamide derivative FLZ attenuates neuroinflammation in both in vivo and in vitro Parkinson's disease models

Neuropharmacology

Volumn 75, Issue , 2013, Pages 201-212

  Tai, Wenjiao ^a   Ye, Xuan ^a,c   Bao, Xiuqi ^a   Zhao, Baozhong ^b   Wang, Xiaoliang ^a   Zhang, Dan ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b UNIVERSITY OF CHICAGO   (United States)

^c State University of New Jersey   (United States)

Author keywords

LPS; NADPH oxidase; Neuroinflammation; Parkinson's disease; Src tyrosine kinase

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; ANTIINFLAMMATORY AGENT; APOMORPHINE; DOPAMINE; HOMOVANILLIC ACID; LIPOPOLYSACCHARIDE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; N [2 (4 HYDROXYPHENYL)ETHYL] 2 (2,5 DIMETHOXYPHENYL) 3 (3 METHOXY 4 HYDROXYPHENYL)ACRYLAMIDE; NEUROPROTECTIVE AGENT; NITRIC OXIDE; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOWN REGULATION; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROGLIA; MOUSE; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; OPEN FIELD TEST; PARKINSON DISEASE; PRIORITY JOURNAL; ROTAROD TEST; SUBSTANTIA NIGRA;

DA; DIHYDROXYPHENYLACETIC ACID; DOPAC; DOPAMINE; HOMOVANILLIC ACID; HVA; IBA-1; IONIZED CALCIUM BINDING ADAPTOR MOLECULE-1; LIPOPOLYSACCHARIDE; LPS; NADPH; NADPH OXIDASE; NEUROINFLAMMATION; NF-ΚB; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NITRIC OXIDE; NO; NUCLEAR FACTOR ΚB; ORP; OVERALL ROD PERFORMANCE; PARKINSON'S DISEASE; PD; PHOSPHORYLATED PHOSPHOINOSITIDE 3-KINASE; PI3K; REACTIVE OXYGEN SPECIES; ROS; SN; SRC TYROSINE KINASE; SUBSTANTIA NIGRA; TH; TLRS; TOLL-LIKE RECEPTORS; TYROSINE HYDROXYLASE;

ANIMALS; APOMORPHINE; BENZENEACETAMIDES; CELL LINE; DISEASE MODELS, ANIMAL; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENCEPHALITIS; ENZYME ACTIVATION; ENZYME ACTIVATORS; EXPLORATORY BEHAVIOR; LIPOPOLYSACCHARIDES; MALE; MICE; MOTOR ACTIVITY; PARKINSON DISEASE; PHENOLS; RATS; RATS, WISTAR; SRC-FAMILY KINASES;

EID: 84883520132     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.07.020     Document Type: Article

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