Soluble Prion Protein Binds Isolated Low Molecular Weight Amyloid-β Oligomers Causing Cytotoxicity Inhibition

ACS Chemical Neuroscience

Volumn 6, Issue 12, 2015, Pages 1972-1980

  Williams, Thomas L ^a   Choi, Jin Kyu ^a   Surewicz, Krystyna ^a   Surewicz, Witold K ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Amyloid ; Neurotoxicity; Oligomers; Prion Protein

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; OLIGOMER; RECOMBINANT PRION PROTEIN; RECOMBINANT PROTEIN; TETRAMER; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; CALCEIN; FLUORESCEIN DERIVATIVE; LACTATE DEHYDROGENASE; PRION; PROTEIN BINDING;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL DEATH; CELL VACUOLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; HIPPOCAMPAL NEURONAL CULTURE; LARGE UNILAMELLAR VESICLE; LIPID BILAYER; MEMBRANE TRANSPORT; NERVE CELL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PHOTOINDUCED CROSS LINKING OF UNMODIFIED PROTEIN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; RAT; ANIMAL; ATOMIC FORCE MICROSCOPY; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; HIPPOCAMPUS; HUMAN; MAMMALIAN EMBRYO; METABOLISM; MOLECULAR WEIGHT; PRION; SPRAGUE DAWLEY RAT; SURFACE PLASMON RESONANCE;

AMYLOID BETA-PEPTIDES; ANIMALS; EMBRYO, MAMMALIAN; FLUORESCEINS; HIPPOCAMPUS; HUMANS; L-LACTATE DEHYDROGENASE; MICROSCOPY, ATOMIC FORCE; MOLECULAR WEIGHT; NEURONS; PRIONS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SURFACE PLASMON RESONANCE;

EID: 84950301397     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.5b00229     Document Type: Article

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