β-amyloid monomers are neuroprotective

Journal of Neuroscience

Volumn 29, Issue 34, 2009, Pages 10582-10587

  Giuffrida, Maria Laura ^a   Caraci, Filippo ^a   Pignataro, Bruno ^b   Cataldo, Sebastiano ^b   De Bona, Paolo ^a   Bruno, Valeria ^c,d   Molinaro, Gemma ^d   Pappalardo, Giuseppe ^e   Messina, Angela ^f   Palmigiano, Angelo ^f   Garozzo, Domenico ^f   Nicoletti, Ferdinando ^c,d   Rizzarelli, Enrico ^a,g   Copani, Agata ^a,e  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d IRCCS NEUROMED   (Italy)

^e CNR   (Italy)

^f Istituto di Chimica e Tecnologia dei Polimeri   (Italy)

^g NATIONAL INSTITUTE OF BIOSTRUCTURES AND BIOSYSTEMS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NERVE CELL; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RABBIT;

AMYLOID BETA-PROTEIN; ANALYSIS OF VARIANCE; ANIMALS; BUTADIENES; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; N-METHYLASPARTATE; NEURONS; NEUROPROTECTIVE AGENTS; NITRILES; PEPTIDE FRAGMENTS; PODOPHYLLOTOXIN; RATS; TYRPHOSTINS;

EID: 69449090793     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1736-09.2009     Document Type: Article

References (31)

1. Adams JM, Cory S (1998) The Bcl-2 protein family: arbiters of cell survival. Science 281:1322-1326. (Pubitemid 28406819)
2. Avruch J (1998) Insulin signal transduction through protein kinase cascades. Mol Cell Biochem 182:31-48. (Pubitemid 28181646)
3. Brody DL, Magnoni S, Schwetye KE, Spinner ML, Esparza TJ, Stocchetti N, Zipfel GJ, Holtzman DM (2008) Amyloid-beta dynamics correlate with neurological status in the injured human brain. Science 321:1221-1224.
4. Copani A, Koh JY, Cotman CW (1991) Beta-amyloid increases neuronal susceptibility to injury by glucose deprivation. Neuroreport 2:763-765.
5. Copani A, Condorelli F, Caruso A, Vancheri C, Sala A, Giuffrida Stella AM, Canonico PL, Nicoletti F, Sortino MA (1999) Mitotic signaling by beta-amyloid causes neuronal death. FASEB J 13:2225-2234.
6. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, Copeland RA, Magolda RL, Scherle PA, Trzaskos JM (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273:18623-18632. (Pubitemid 28334795)
7. Franke TF, Kaplan DR, Cantley LC (1997) PI3K: downstream AKTion blocks apoptosis. Cell 88:435-437.
8. Giraud J, Leshan R, Lee Y-H, White MF (2004) Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling. J Biol Chem 279:3447-3454. (Pubitemid 38140583)
9. Gregory GC, Halliday GM (2005) What is the dominant Abeta species in human brain tissue? A review. Neurotox Res 7:29-41.
10. Hansson O, Zetterberg H, Buchhave P, Andreasson U, Londos E, Minthon L, Blennow K (2007) Prediction of Alzheimer's disease using the CSF Abeta42/Abeta40 ratio in patients with mild cognitive impairment. Dement Geriatr Cogn Disord 23:316-320. (Pubitemid 46631938)
11. Hynd MR, Scott HL, Dodd PR (2004) Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease. Neurochem Int 45:583-595. (Pubitemid 38844879)
12. Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R (2003) APP processing and synaptic function. Neuron 37: 925-937.
13. Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ (2008) Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. J Neurosci 28:4231-4237.
14. Kremer JJ, MurphyRM (2003) Kinetics of adsorption of β-amyloid peptide Aβ(1-40) to lipid bilayers. J Biochem Biophys Methods 57:159-169.
15. Kusumoto Y, Lomakin A, Teplow DB, Benedek GB (1998) Temperature dependence of amyloid beta-protein fibrillization. Proc Natl Acad Sci U S A 95:12277-12282. (Pubitemid 28483756)
16. 1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A 95:6448-6453.
17. Lesne S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH (2006) A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440:352-357.
18. Nilsberth C, Westlind-Danielsson A, Eckman CB, CondronMM,Axelman K, Forsell C, Stenh C, Luthman J, Teplow DB, Younkin SG, Näslund J, Lannfelt L (2001) The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nat Neurosci 4:887-893.
19. Pignataro B, Chi L, Gao S, Anczykowski B, Niemeyer C, Adler M, Fuchs H (2002) Dynamic scanning force microscopy study of self-assembled DNA-protein nanostructures. Appl Phys A Mater Sci Process 74: 447-452. (Pubitemid 34268701)
20. Plant LD, Boyle JP, Smith IF, Peers C, PearsonHA (2003) The production of amyloid beta peptide is a critical requirement for the viability of central neurons. J Neurosci 23:5531-5535.
21. Rodziewicz-Motowidło S, Juszczyk P, Sikorska E, Spodzieja M, Kołodziejczyk AS (2008) The Arctic mutation alters helix length and type in the 11-28 beta-amyloid peptide monomer-CD, NMR and MD studies in an SDS micelle. J Struct Biol. Advance online publication. Retrieved July 24, 2008. doi:10.1016/j.jsb.2008.07.010.
22. Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ (2008) Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 14:837-842.
23. Shoji M (2002) Cerebrospinal fluid Abeta40 and Abeta42: natural course and clinical usefulness. Front Biosci 7:d997-d1006.
24. Soucek T, Cumming R, Dargusch R, Maher P, Schubert D (2003) The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide. Neuron 39:43-56. (Pubitemid 36830947)
25. Townsend M, Mehta T, Selkoe DJ (2007) Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem 282:33305-33312. (Pubitemid 350159548)
26. Vasilcanu D, Girnita A, Girnita L, Vasilcanu R, Axelson M, LarssonO (2004) The cyclolignan PPP induces activation loop-specific inhibition of tyrosine phosphorylation of the insulin-like growth factor-1 receptor. Link to the phosphatidyl inositol-3 kinase/Akt apoptotic pathway. Oncogene 23: 7854-7862.
27. Vlahos CJ, Matter WF, Hui KY, Brown RF (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269:5241-5248. (Pubitemid 2045363)
28. Walsh DM, Selkoe DJ (2007) A beta oligomers - a decade of discovery. J Neurochem 101:1172-1184.
29. Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416:535-539. (Pubitemid 34288854)
30. Willert K, Nusse R (1998) β-Catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev 8:95-102.
31. Xie L, Helmerhorst E, Taddei K, Plewright B, Van Bronswijk W, Martins R (2002) Alzheimer's beta amyloid peptides compete for insulin binding to the insulin receptor. J Neurosci 22:RC221.