The impact of Vitamin D levels on inflammatory status: A systematic review of immune cell studies

PLoS ONE

Volumn 10, Issue 11, 2015, Pages

  Calton, Emily K ^a   Keane, Kevin N ^a   Newsholme, Philip ^a   Soares, Mario J ^a  

^a CURTIN UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; CALCITRIOL; COLECALCIFEROL; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN P42; REACTIVE OXYGEN METABOLITE; STAT5 PROTEIN; SYNAPTOPHYSIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; VITAMIN D; CYTOKINE; MITOGEN ACTIVATED PROTEIN KINASE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; HUMAN; IMMUNOCOMPETENT CELL; INFLAMMATION; OXIDATIVE STRESS; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SYSTEMATIC REVIEW; TRANSCRIPTION REGULATION; VITAMIN BLOOD LEVEL; ANIMAL; CELL LINE; IMMUNOLOGY; MONONUCLEAR CELL;

ANIMALS; CELL LINE; CYTOKINES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; LEUKOCYTES, MONONUCLEAR; VITAMIN D;

EID: 84950298485     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0141770     Document Type: Article

References (69)

1. Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care. 2004; 27(3):813-23. PMID: 14988310
2. Lontchi-Yimagou E, Sobngwi E, Matsha TE, Kengne AP. Diabetes mellitus and inflammation. Curr Diab Rep. 2013; 13(3):435-44. doi: 10.1007/s11892-013-0375-y PMID: 23494755
3. Akash MS, Rehman K, Chen S. Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus. J Cell Biochem. 2013; 114(3):525-31. doi: 10.1002/jcb.24402 PMID: 22991242
4. Frostegard J, Ulfgren AK, Nyberg P, Hedin U, Swedenborg J, Andersson U, et al. Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines. Atherosclerosis. 1999; 145(1):33-43. PMID: 10428293
5. Ikeoka D, Mader JK, Pieber TR. Adipose tissue, inflammation and cardiovascular disease. Rev Assoc Med Bras. 2010; 56(1):116-21. PMID: 20339797
6. Zelkha SA, Freilich RW, Amar S. Periodontal innate immune mechanisms relevant to atherosclerosis and obesity. Periodontol 2000.2010; 54(1):207-21. doi: 10.1111/j.1600-0757.2010.00358.x PMID: 20712641
7. Abe J, Manabe I, Aikawa M, Aikawa E. Cardiovascular Inflammation 2012: Reactive oxygen species, SUMOylation, and biomarkers in cardiovascular inflammation. Int J Inflam. 2013; 2013:953463. doi: 10.1155/2013/953463 PMID: 23555068
8. Luft VC, Schmidt MI, Pankow JS, Couper D, Ballantyne CM, Young JH, et al. Chronic inflammation role in the obesity-diabetes association: a case-cohort study. Diabetol Metab Syndr. 2013; 5(1):31. doi: 10.1186/1758-5996-5-31 PMID: 23806173
9. Pecht T, Gutman-Tirosh A, Bashan N, Rudich A. Peripheral blood leucocyte subclasses as potential biomarkers of adipose tissue inflammation and obesity subphenotypes in humans. Obes Rev. 2014; 15 (4):322-37. doi: 10.1111/obr.12133 PMID: 24251825
10. Calton EK, Keane K, Soares MJ. The potential regulatory role of vitamin D in the bioenergetics of inflammation. Curr Opin Clin Nutr Metab Care 2015; 18(4):367-73. doi: 10.1097/MCO.0000000000000186 PMID:26049634
11. Stepien M, Nugent AP, Brennan L. Metabolic profiling of human peripheral blood mononuclear cells: influence of vitamin d status and gender. Metabolites. 2014; 4(2):248-59. doi: 10.3390/metabo4020248 PMID: 24957025
12. Daly RM, Gagnon C, Lu ZX, Magliano DJ, Dunstan DW, Sikaris KA, et al. Prevalence of vitamin D deficiency and its determinants in Australian adults aged 25 years and older: a national, population-based study. Clin Endocrinol (Oxf). 2012; 77(1):26-35.
13. Menezes AR, Lamb MC, Lavie CJ, DiNicolantonio JJ. Vitamin D and atherosclerosis. Current Opinion in Cardiology. 2014; 29(6):571-7. doi: 10.1097/HCO.0000000000000108 PMID: 25144342
14. Kayaniyil S, Vieth R, Harris SB, Retnakaran R, Knight JA, Gerstein HC, et al. Association of 25(OH)D and PTH with metabolic syndrome and its traditional and nontraditional components. J Clin Endocrinol Metab. 2011; 96(1):168-75. doi: 10.1210/jc.2010-1439 PMID: 20980431
15. Kayaniyil S, Vieth R, Retnakaran R, Knight JA, Qi Y, Gerstein HC, et al. Association of vitamin D with insulin resistance and β-cell dysfunction in subjects at risk for type 2 diabetes. Diabetes Care. 2010; 33 (6):1379-81. doi: 10.2337/dc09-2321 PMID: 20215450
16. Bonakdaran S, Varasteh AR. Correlation between serum 25 hydroxy vitamin D3 and laboratory risk markers of cardiovascular diseases in type 2 diabetic patients. Saudi Med J. 2009; 30(4):509-14. PMID: 19370277
17. Pilz S, Kienreich K, Rutters F, de Jongh R, van Ballegooijen AJ, Grubler M, et al. Role of vitamin D in the development of insulin resistance and type 2 diabetes. Curr Diab Rep. 2013; 13(2):261-70. doi: 10.1007/s11892-012-0358-4 PMID: 23264189
18. Liu J. Vitamin D content of food and its contribution to vitamin D status: a brief overview and Australian focus. Photochem Photobiol Sci. 2012; 11(12):1802-7. doi: 10.1039/c2pp25150g PMID: 22945547
19. Bouillon R, Carmeliet G, Lieben L, Watanabe M, Perino A, Auwerx J, et al. Vitamin D and energy homeostasis-of mice and men. Nat Rev Endocrinol. 2014; 10(2):79-87. doi: 10.1038/nrendo.2013.226 PMID: 24247221
20. White JH. Vitamin D metabolism and signaling in the immune system. Rev Endocr Metab Disord. 2012; 13(1):21-9. doi: 10.1007/s11154-011-9195-z PMID: 21845364
21. Tran B, Armstrong BK, McGeechan K, Ebeling PR, English DR, Kimlin MG, et al. Predicting vitamin D deficiency in older Australian adults. Clin Endocrinol (Oxf). 2013; 79(5):631-40.
22. Zhang Y, Leung DY, Richers BN, Liu Y, Remigio LK, Riches DW, et al. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol. 2012; 188(5):2127-35. doi: 10.4049/jimmunol.1102412 PMID: 22301548
23. Badenhoop K, Kahles H, Penna-Martinez M. Vitamin D, immune tolerance, and prevention of type 1 diabetes. Curr Diab Rep. 2012; 12(6):635-42. doi: 10.1007/s11892-012-0322-3 PMID: 22976537
24. Jayaratne N, Hughes MC, Ibiebele TI, vanden Akker S, van der Pols JC. Vitamin D intake in Australian adults and the modeled effects of milk and breakfast cereal fortification. Nutrition. 2013; 29(7-8):1048-53. doi: 10.1016/j.nut.2013.02.011 PMID: 23759266
25. Sundaram K, Sambandam Y, Tsuruga E, Wagner CL, Reddy SV. 1alpha,25-dihydroxyvitamin D3 modulates CYP2R1 gene expression in human oral squamous cell carcinoma tumor cells. Horm Cancer. 2014; 5(2):90-7. doi: 10.1007/s12672-014-0170-5 PMID: 24497297
26. De Vita F, Lauretani F, Bauer J, Bautmans I, Shardell M, Cherubini A, et al. Relationship between vitamin D and inflammatory markers in older individuals. Age (Dordr). 2014; 36(4):9694.
27. Mellenthin L, Wallaschofski H, Grotevendt A, Völzke H, Nauck M, Hannemann A. Association between serum vitamin D concentrations and inflammatory markers in the general adult population. Metabolism. 2014; 63(8):1056-62. doi: 10.1016/j.metabol.2014.05.002 PMID: 24928661
28. Mason C, Xiao L, Imayama I, Duggan C, Wang CY, Korde L, et al. Vitamin D3 supplementation during weight loss: a double-blind randomized controlled trial. Am J Clin Nutr. 2014; 99(5):1015-25. doi: 10.3945/ajcn.113.073734 PMID: 24622804
29. Chandler PD, Scott JB, Drake BF, Ng K, Manson JE, Rifai N, et al. Impact of vitamin D supplementation on inflammatory markers in African Americans: results of a four-arm, randomized, placebo-controlled trial. Cancer Prev Res (Phila). 2014; 7(2):218-25.
30. Hossein-Nezhad A, Mirzaei K, Keshavarz SA, Ansar H, Saboori S, Tootee A. Evidences of dual role of vitamin D through cellular energy homeostasis and inflammation pathway in risk of cancer in obese subjects. Minerva Med. 2013; 104(3):295-307. PMID: 23748283
31. Gonzalez-Molero I, Rojo-Martinez G, Morcillo S, Gutierrez C, Rubio E, Perez-Valero V, et al. Hypovitaminosis D and incidence of obesity: a prospective study. Eur J Clin Nutr. 2013; 67(6):680-2. doi: 10.1038/ejcn.2013.48 PMID: 23422920
32. Sloka S, Silva C, Wang J, Yong VW. Predominance of Th2 polarization by Vitamin D through a STAT6-dependent mechanism. Journal of Neuroinflammation. 2011; 8.
33. Giulietti A, van Etten E, Overbergh L, Stoffels K, Bouillon R, Mathieu C. Monocytes from type 2 diabetic patients have a pro-inflammatory profile. 1,25-Dihydroxyvitamin D(3) works as anti-inflammatory. Diabetes Res Clin Pract. 2007; 77(1):47-57. PMID: 17112620
34. Neve A, Corrado A, Cantatore F. Immunomodulatory effects of vitamin D in peripheral blood monocyte-derived macrophages from patients with rheumatoid arthritis. Clin Exp Med. 2013:1-9.
35. Vuolo L, Di Somma C, Faggiano A, Colao A. Vitamin D and cancer. Front Endocrinol (Lausanne). 2012; 3:58.
36. Khoo AL, Chai LY, Koenen HJ, Sweep FC, Joosten I, Netea MG, et al. Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals. Clin Exp Immunol. 2011; 164 (1):72-9. doi: 10.1111/j.1365-2249.2010.04315.x PMID: 21323660
37. Takahashi K, Nakayama Y, Horiuchi H, Ohta T, Komoriya K, Ohmori H, et al. Human neutrophils express messenger RNA of vitamin D receptor and respond to 1alpha,25-dihydroxyvitamin D3. Immunopharmacol Immunotoxicol. 2002; 24(3):335-47. PMID: 12375732
38. Adorini L. Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting autoimmune diabetes. Ann NY Acad Sci. 2003; 987:258-61. PMID: 12727648
39. Mocanu V, Oboroceanu T, Zugun-Eloae F. Current status in vitamin D and regulatory T cells - immunological implications. RevMedChirSocMed Nat Iasi. 2013; 117(4):965-73. PMID: 24502077
40. Wang YC, Hsieh CC, Kuo HF, Tsai MK, Yang SN, Kuo CH, et al. Effect of vitamin D-3on monocyte chemoattractant protein 1 production in monocytes and macrophages. Acta Cardiologica Sinica. 2014; 30 (2):144-50.
41. Yang MX, Shen ZN, Chen DY, Gan H, Shen Q, Yang B, et al. Effects of 1,25-(OH)(2)D-3 on the expressions of vitamin D receptor, STAT5 and cytoskeletal rearrangement in human monocytes incubated with sera from type 2 diabetes patients and diabetic nephropathy patients with uremia. Inflammation Research. 2012; 61(5):511-20. doi: 10.1007/s00011-012-0441-y PMID: 22322482
42. Jain SK, Micinski D. Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes. Biochem Biophys Res Commun. 2013; 437(1):7-11. doi: 10.1016/j.bbrc.2013.06.004 PMID: 23770363
43. Sadeghi K, Wessner B, Laggner U, Ploder M, Tamandl D, Friedl J, et al. Vitamin D3down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immunol. 2006; 36(2):361-70. PMID: 16402404
44. Rausch-Fan X, Leutmezer F, Willheim M, Spittler A, Bohle B, Ebner C, et al. Regulation of cytokine production in human peripheral blood mononuclear cells and allergen-specific Th cell clones by 1 alpha,25-dihydroxyvitamin D-3. International Archives of Allergy and Immunology. 2002; 128(1):33-41. PMID: 12037399
45. Giovannini L, Panichi V, Migliori M, De Pietro S, Bertelli AAE, Fulgenzi A, et al. 1,25-dihydroxyvitamin D-3 dose-dependently inhibits LPS-induced cytokines production in PBMC modulating intracellular calcium. Transplantation Proceedings. 2001; 33(3):2366-8. PMID: 11377561
46. Di Rosa M, Malaguarnera G, De Gregorio C, Palumbo M, Nunnari G, Malaguarnera L. Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages. Cellular Immunology. 2012; 280 (1):36-43. doi: 10.1016/j.cellimm.2012.10.009 PMID: 23261827
47. Tulk SE, Liao KC, Muruve DA, Li Y, Beck PL, MacDonald JA. Vitamin D(3) metabolites enhance the NLRP3-dependent secretion of IL-1beta from human THP-1 monocytic cells. J Cell Biochem. 2015; 116(5):711-20. doi: 10.1002/jcb.24985 PMID: 25639477
48. Matilainen JM, Husso T, Toropainen S, Seuter S, Turunen MP, Gynther P, et al. Primary effect of 1 alpha,25(OH)(2)D-3 on IL-10 expression in monocytes is short-term down-regulation. Biochim Biophys Acta. 2010; 1803(11):1276-86. PMID: 20691220
49. Matilainen JM, Rasanen A, Gynther P, Vaisanen S. The genes encoding cytokines IL-2, IL-10 and IL-12Bare primary 1 alpha,25(OH)(2)D-3 target genes. J Steroid Biochem and Mol Biol. 2010; 121(1-2):142-5.
50. Lee BNR, Kim TH, Jun JB, Yoo DH, Woo JH, Choi SJ, et al. Upregulation of interleukin-1β production by 1,25-Dihydroxyvitamin D3 in activated human macrophages. Molecular Biology Reports. 2011; 38 (3):2193-201. doi: 10.1007/s11033-010-0348-z PMID: 20848209
51. Cantorna MT, Snyder L, Lin YD, Yang L. Vitamin D and 1,25(OH)2D regulation of T cells. Nutrients. 2015; 7(4):3011-21. doi: 10.3390/nu7043011 PMID: 25912039
52. Ojaimi S, Skinner NA, Strauss BJ, Sundararajan V, Woolley I, Visvanathan K. Vitamin D deficiency impacts on expression of toll-like receptor-2 and cytokine profile: a pilot study. J Transl Med. 2013; 11:176. doi: 10.1186/1479-5876-11-176 PMID: 23875738
53. Takahashi K, Horiuchi H, Ohta T, Komoriya K, Ohmori F, Kamimura T. 1 alpha,25-dihydroxyvitamin D-3 suppresses interleukin-1 beta-induced interleukin-8 production in human whole blood: An involvement of erythrocytes in the inhibition. Immunopharmacology and Immunotoxicology. 2002; 24(1):1-15. PMID: 12022438
54. Du T, Zhou Z-G, You S, Huang G, Lin J, Yang L, et al. Modulation of monocyte hyperresponsiveness to TLR ligands by 1,25-dihydroxy-vitamin D3 from LADA and T2DM. Diabetes Research and Clinical Practice. 2009; 83(2):208-14. doi: 10.1016/j.diabres.2008.09.046 PMID: 19010563
55. Thien R, Baier K, Pietschmann P, Peterlik M, Willheim M. Interactions of 1 alpha,25-dihydroxyvitamin D3 with IL-12 and IL-4 on cytokine expression of human T lymphocytes. Journal of Allergy and Clinical Immunology. 2005; 116(3):683-9. PMID: 16159643
56. Zhang Y, Leung DYM, Goleva E. Vitamin D enhances glucocorticoid action in human monocytes. Journal of Biological Chemistry. 2013; 288(20):14544-53. doi: 10.1074/jbc.M112.427054 PMID: 23572530
57. Jeffery LE, Burke F, Mura M, Zheng Y, Qureshi OS, Hewison M, et al. 1,25-Dihydroxyvitamin D3and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory Tcells expressing CTLA-4 and FoxP3. J Immunol. 2009; 183(9):5458-67. doi: 10.4049/jimmunol.0803217 PMID: 19843932
58. Jirapongsananuruk O, Melamed I, Leung DYM. Additive immunosuppressive effects of 1,25-dihydroxyvitamin D3 and corticosteroids on TH1, butnotTH2, responses. J Allergy Clin Immunol. 2000; 106 (5):981-5. PMID: 11080724
59. Newsholme P, Haber EP, Hirabara SM, Rebelato ELO, Procopio J, Morgan D, et al. Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. J Physiol. 2007; 583(Pt 1):9-24. PMID: 17584843
60. Ahmad R, Al-Mass A, Atizado V, Al-Hubail A, Al-Ghimlas F, Al-Arouj M, et al. Elevated expression of the toll like receptors 2 and 4 in obese individuals: its significance for obesity-induced inflammation. J Inflamm (Lond). 2012; 9(1):48.
61. Edfeldt K, Bennet AM, Eriksson P, Frostegard J, Wiman B, Hamsten A, et al. Association of hyporesponsive toll-like receptor 4 variants with risk of myocardial infarction. Eur Heart J. 2004; 25 (16):1447-53. PMID: 15302104
62. Vitseva OI, Tanriverdi K, Tchkonia TT, Kirkland JL, McDonnell ME, Apovian CM, et al. Inducible toll-like receptor and NF-KB regulatory pathway expression in human adipose tissue. Obesity. 2008; 16 (5):932-7. doi: 10.1038/oby.2008.25 PMID: 18292749
63. Lee JY, Zhao L, Youn HS, Weatherill AR, Tapping R, Feng L, et al. Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. J Biol Chem. 2004; 279(17):16971-9. PMID: 14966134
64. Tarkowski A, Bjersing J, Shestakov A, Bokarewa MI. Resistin competes with lipopolysaccharide for binding to toll-like receptor 4. J Cell Mol Med. 2010; 14(6b):1419-31. doi: 10.1111/j.1582-4934.2009.00899.x PMID: 19754671
65. Pang SS, Le YY. Role of resistin in inflammation and inflammation-related diseases. Cell Mol Immunol. 2006; 3(1):29-34. PMID: 16549046
66. Poulain-Godefroy O, LeBacquer O, Plancq P, Lecceur C, Pattou F, Frühbeck G, et al. Inflammatory role of toll-like receptors in human and murine adipose tissue. Mediators of Inflammation. 2010; 2010:823486. doi: 10.1155/2010/823486 PMID: 20339530
67. Zhang AB, Zheng SS. Strong additive effect of calcitriol and cyclosporine A on lymphocyte proliferation in vitro and rat liver allotransplantations in vivo. Chinese Medical Journal. 2006; 119(24):2090-5. PMID: 17199961
68. Hayden MS, West AP, Ghosh S. NF-[kappa]Bandthe immune response. Oncogene. 0000; 25 (51):6758-80. PMID: 17072327
69. Hewison M. Antibacterial effects of vitamin D. Nat Rev Endocrinol. 2011; 7(6):337-45. doi: 10.1038/nrendo.2010.226 PMID: 21263449