Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes

Biochemical and Biophysical Research Communications

Volumn 437, Issue 1, 2013, Pages 7-11

  Jain, Sushil K ^a   Micinski, David ^a  

^a Louisiana State University School of Medicine Shreveport   (United States)

Author keywords

Diabetes; Glutamate cysteine ligase; Glutathione reductase; GSH; Vitamin D

Indexed keywords

GLUCOSE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE REDUCTASE; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; VITAMIN D;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME INHIBITION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; MONOCYTE; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; VITAMIN SUPPLEMENTATION;

DIABETES; GCLC; GCLM; GLUTAMATE CYSTEINE LIGASE; GLUTAMATE CYSTEINE LIGASE CATALYTIC UNIT; GLUTAMATE CYSTEINE LIGASE MODULATORY UNIT; GLUTATHIONE; GLUTATHIONE REDUCTASE; GR; GSH; REACTIVE OXYGEN SPECIES; ROS; VITAMIN D;

CHEMOKINE CCL2; GLUCOSE; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE REDUCTASE; HUMANS; INTERLEUKIN-8; MONOCYTES; REACTIVE OXYGEN SPECIES; U937 CELLS; UP-REGULATION; VITAMIN D;

EID: 84880513183     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.06.004     Document Type: Article

References (37)

1. Townsend D.M., Tew K.D., Tapiero H. The importance of glutathione in human disease. Biomed. Pharmacother. 2003, 57:145-155.
2. Qin L., Bartlett H., Griffiths H.R., et al. Macular pigment optical density is related to blood glutathione levels in healthy individuals. Invest. Ophthalmol. Vis. Sci. 2011, 52:5029-5033.
3. Zampagni M., Wright D., Cascella R., et al. Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models. Free Rad. Biol. Med. 2012, 52:1362-1371.
4. Dröge W. Oxidative stress and ageing: is ageing a cysteine deficiency syndrome?. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2005, 360:2355-2372.
5. Sekhar R.V., McKay S.V., Patel S.G., et al. Glutathione synthesis is diminished in patients with uncontrolled diabetes and restored by dietary supplementation with cysteine and glycine. Diabetes Care 2011, 34:162-167.
6. Morris D., Khurasany M., Nguyen T., Kim J., Guilford F., Mehta R., Gray D., Saviola B., Venketaraman V. Glutathione and infection. Biochim. Biophys. Acta 2013, 1830:3329-3349.
7. Darmaun D., Smith S.D., Sweeten S., Hartman B.K., Welch C., Mauras N. Poorly controlled type 1 diabetes is associated with altered glutathione homeostasis in adolescents: apparent resistance to N-acetylcysteine supplementation. Pediatr. Diabetes 2008, 9:577-582.
8. Lamendola C.A., Ariel D., Feldman D., Reaven G.M. Relation between obesity, insulin resistance and 25 hydroxyvitamin D. Am. J. Clin. Nutr. 2012, 95:1055-1059.
9. Pittas A.G., Chung M., Trikalinos T., Mitri J., Brendel M., Patel K., Lichtenstein A.H., Lau J., Balk E.M. Vitamin D and cardiometabolic outcomes: a systematic review. Ann. Intern. Med. 2010, 152(5):307-314.
10. Rosen C.J., Adams J.S., Bikle D.D., Black D.M., Demay M.B., Manson J.E., Murad M.H., Kovacs C.S. The nonskeletal effects of vitamin D: an endocrine society scientific statement. Endocr. Rev. 2012, 33(3):456-492.
11. Kabadi S.M., Lee B.K., Liu L. Joint effects of obesity and vitamin D insufficiency on insulin resistance and type 2 diabetes: results from the NHANES 2001-2006. Diabetes Care 2012, 35:2048-2054.
12. Jain S.K., McVie R. Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in Type-I diabetic patients. Diabetes 1999, 48:1850-1855.
13. Jain S.K., McVie R. Effect of glycemic control, race (white versus black), and duration of diabetes on reduced glutathione content in erythrocytes of diabetic patients. Metabolism 1994, 43:306-309.
14. Jain S.K., Kannan K., Lim G., McVie R., Bocchini J.A. Hyperketonemia increases TNF-α secretion in cultured U937 monocytes and Type-1 diabetic patients and is apparently mediated by oxidative stress and cAMP-deficiency. Diabetes 2002, 51:2287-2293.
15. Manna P., Jain S.K. Hydrogen sulfide and l-cysteine increase phosphatidylinositol 3,4,5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinase (AKT)/protein kinase Cζ/λ (PKCζ/λ) in 3T3l1 adipocytes. J. Biol. Chem. 2011, 18(286):39848-39859.
16. Pfeiffer C.M., Huff D.L., Gunter E.W. Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting. Clin. Chem. 1999, 45:290-292.
17. Beutler E. Red Cell Metabolism. A Manual of Biochemical Methods 1984, Grune & Stratton, Orlando.
18. Rubinstein R., Genaro A.M., Motta A., Cremaschi G., Wald M.R. Impaired immune responses in streptozotocin-induced type I diabetes in mice. Involvement of high glucose. Clin. Exp. Immunol. 2008, 154:235-246.
19. Franklin C.C., Backos D.S., Mohar I., White C.C., Forman H.J., Kavanagh T.J. Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase. Mol. Aspects Med. 2009, 30:86-98.
20. Langton W., Circu M.L., Aw T.Y. Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: influence of low glucose. Free Rad. Biol. Med. 2008, 45:1591-1599.
21. Kim S.K., Woodcroft K.J., Khodadadeh S.S., Novak R.F. Insulin signaling regulates gamma-glutamylcysteine ligase catalytic subunit expression in primary cultured hepatocytes. J. Pharmacol. Exp. Ther. 2004, 311:99-108.
22. Jain S.K. Hyperglycemia can cause membrane lipid peroxidation and osmotic fragility in human red blood cells. J. Biol. Chem. 1989, 264:21340-21345.
23. Jain S.K., McVie R., Duett J., Herbst J.J. Erythrocyte membrane lipid peroxidation and glycosylated hemoglobin in diabetes. Diabetes 1989, 38:1539-1543.
24. Rains J.L., Jain S.K. Oxidative stress, insulin signaling, and diabetes. Free Rad. Biol. Med. 2011, 50:567-575.
25. Blouet C.B., Mariotti F., Azzout-Marniche D., et al. Dietary cysteine alleviates sucrose-induced oxidative stress and insulin resistance. Free Rad. Biol. Med. 2007, 42:1089-1097.
26. Jain S.K., Velusamy T., Croad J.L., Rains J.L., Bull R. l-Cysteine supplementation lowers blood glucose, glycated hemoglobin, CRP, MCP-1, oxidative stress and inhibits NFkB activation in the livers of Zucker diabetic rats. Free Rad. Biol. Med. 2009, 46:1633-1638.
27. De Mattia G., Bravi M.C., Laurenti O., Cassone-Faldetta M., Armiento A., Ferri C., Balsano F. Influence of reduced glutathione infusion on glucose metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism 1998, 47:993-997.
28. Ammon H.P., Abdel-hamid M. Potentiation of the insulin-releasing capacity of tolbutamide by thiols: studies on the isolated perfused pancreas. Naunyn Schmiedebergs Arch. Pharmacol. 1981, 317:262-267.
29. Kim B.S., Cha H.N., Kim Y.W., et al. Inhibition of lipid infusion-induced skeletal muscle insulin resistance by cotreatment with tempol and glutathione in mice. J. Pharmacol. Sci. 2009, 110:370-380.
30. Guarino M.P., Macedo M.P. Co-administration of glutathione and nitric oxide enhances insulin sensitivity in Wistar rats. Br. J. Pharmacol. 2006, 147:959-965.
31. Egashira K. Molecular mechanisms mediating inflammation in vascular disease: special reference to monocyte chemoattractant protein-1. Hypertension 2003, 41:834-841.
32. Pittas A.G., Sun Q., Manson J.E., Dawson-Hughes B., Hu F.B. Plasma 25-hydroxyvitamin D concentration and risk of incident type 2 diabetes in women. Diabetes Care 2010, 33:2021-2023.
33. Manna P., Jain S.K. Vitamin D up-regulates glucose transporter 4 (GLUT4) translocation and glucose utilization mediated by cystathionine-γ-lyase (CSE) activation and H2S formation in 3T3L1 adipocytes. J. Biol. Chem. 2012, 287:42324-42332.
34. Jain S.K., Manna P., Micinski D., Lieblong B.J., Kahlon G., Morehead L., Hoeldtke R., Bass P.F., Levine S.N. In African American type 2 diabetic patients, is vitamin D deficiency associated with lower blood levels of hydrogen sulfide and cyclic adenosine monophosphate, and elevated oxidative stress?. Antioxid. Redox Signal. 2013, 18:1154-1158.
35. Reis J.P., Michos E.D., von Mühlen D., Miller E.R. Differences in vitamin D status as a possible contributor to the racial disparity in peripheral arterial disease. Am. J. Clin. Nutr. 2008, 88:1469-1477.
36. Richie J.P., Muscat J.E., Ellison I., Calcagnotto A., Kleinman W., El-Bayoumy K. Association of selenium status and blood glutathione concentrations in blacks and whites. Nutr. Cancer 2011, 63:367-375.
37. Jain S.K. Effect of glucose-6-phosphate dehydrogenase deficiency on reduced and oxidized glutathione and lipid peroxide levels in the blood. Clin. Chim. Acta 1996, 253:181-183.