Vitamin D enhances glucocorticoid action in human monocytes: Involvement of granulocyte-macrophage colony-stimulating factor and mediator complex subunit 14

Journal of Biological Chemistry

Volumn 288, Issue 20, 2013, Pages 14544-14553

  Zhang, Yong ^a   Leung, Donald Y M ^a,b   Goleva, Elena ^a  

^a DEPARTMENT OF MEDICINE   (United States)

^b University of Colorado Denver and Children s Hospital Colorado   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORY EFFECTS; GENE TRANSCRIPTIONS; GLUCOCORTICOID RECEPTOR; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTORS; HUMAN PERIPHERAL BLOOD; MITOGEN ACTIVATED PROTEIN KINASE; PERIPHERAL BLOOD MONONUCLEAR CELLS; RESPONSE ELEMENTS;

ACETYLATION; BODY FLUIDS; CYTOLOGY; HORMONES; TISSUE CULTURE; TRANSCRIPTION; VITAMINS;

MACROPHAGES;

BIOLOGICAL MARKER; CALCITRIOL; CALCITRIOL RECEPTOR; CELL PROTEIN; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HISTONE H4; INTERLEUKIN 6; MEDIATOR COMPLEX SUBUNIT 14; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD14+ T LYMPHOCYTE; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME SYNTHESIS; GENE; GENE CONTROL; GENE EXPRESSION; HISTONE ACETYLATION; HORMONE INHIBITION; HORMONE RESPONSE; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; MKP 1 GENE; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RECEPTOR BINDING; TRANSCRIPTION INITIATION SITE;

CHROMATIN IMMUNOPRECIPITATION (CHIP); GLUCOCORTICOID RECEPTOR; INFLAMMATION; MONOCYTES; VITAMIN D;

ANTIGENS, CD14; COCULTURE TECHNIQUES; DUAL SPECIFICITY PHOSPHATASE 1; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; LEUKOCYTES, MONONUCLEAR; MEDIATOR COMPLEX; MONOCYTES; PROMOTER REGIONS, GENETIC; U937 CELLS; VITAMIN D;

EID: 84877884737     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.427054     Document Type: Article

References (49)

1. Holick, M. F. (2007) Vitamin D deficiency. N. Engl. J. Med. 357, 266-281
2. Adams, J. S., and Hewison, M. (2008) Unexpected actions of vitamin D. New perspectives on the regulation of innate and adaptive immunity. Nat. Clin. Pract. Endocrinol. Metab. 4, 80-90 (Pubitemid 351156900)
3. Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., and Evans, R. M. (1995) The nuclear receptor superfamily. The second decade. Cell 83, 835-839
4. 3 receptor in the context of the nuclear receptor superfamily. The central role of the retinoid X receptor. Endocrine 4, 91-105
5. Quack, M., and Carlberg, C. (2000) Ligand-triggered stabilization of vitamin D receptor/retinoid X receptor heterodimer conformations on DR4-type response elements. J. Mol. Biol. 296, 743-756
6. 3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts. J. Bone Miner. Res. 20, 305-317
7. Barnes, P. J. (1998) Anti-inflammatory actions of glucocorticoids. Molecular mechanisms. Clin. Sci. 94, 557-572
8. Rhen, T., and Cidlowski, J. A. (2005) Antiinflammatory action of glucocorticoids. New mechanisms for old drugs. N. Engl. J. Med. 353, 1711-1723
9. Newton, R. (2000) Molecular mechanisms of glucocorticoid action. What is important? Thorax 55, 603-613
10. Beato, M., Herrlich, P., and Schütz, G. (1995) Steroid hormone receptors. Many actors in search of a plot. Cell 83, 851-857 (Pubitemid 26006527)
11. Kassel, O., Sancono, A., Krätzschmar, J., Kreft, B., Stassen, M., and Cato, A. C. (2001) Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1. EMBO J. 20, 7108-7116 (Pubitemid 34062302)
12. Tchen, C. R., Martins, J. R., Paktiawal, N., Perelli, R., Saklatvala, J., and Clark, A. R. (2010) Glucocorticoid regulation of mouse and human dual specificity phosphatase 1 (DUSP1) genes. Unusual cis-acting elements and unexpected evolutionary divergence. J. Biol. Chem. 285, 2642-2652
13. Owens, D. M., and Keyse, S. M. (2007) Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene 26, 3203-3213 (Pubitemid 46763015)
14. Keyse, S. M. (2000) Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr. Opin. Cell Biol. 12, 186-192
15. Clark, A. R. (2003) MAP kinase phosphatase 1. A novel mediator of biological effects of glucocorticoids? J. Endocrinol. 178, 5-12
16. Clark, A. R., and Lasa, M. (2003) Crosstalk between glucocorticoids and mitogen-activated protein kinase signalling pathways. Curr. Opin. Pharmacol. 3, 404-411 (Pubitemid 36908944)
17. Skversky, A. L., Kumar, J., Abramowitz, M. K., Kaskel, F. J., and Melamed, M. L. (2011) Association of glucocorticoid use and low 25-hydroxyvitamin D levels. Results from the National Health and Nutrition Examination Survey (NHANES). 2001-2006. J. Clin. Endocrinol. Metab. 96, 3838-3845
18. Sutherland, E. R., Goleva, E., Jackson, L. P., Stevens, A. D., and Leung, D. Y. (2010) Vitamin D levels, lung function, and steroid response in adult asthma. Am. J. Respir. Crit. Care Med. 181, 699-704
19. Searing, D. A., Zhang, Y., Murphy, J. R., Hauk, P. J., Goleva, E., and Leung, D. Y. (2010) Decreased serum vitaminDlevels in children with asthma are associated with increased corticosteroid use. J. Allergy Clin. Immunol. 125, 995-1000
20. Brehm, J. M., Schuemann, B., Fuhlbrigge, A. L., Hollis, B. W., Strunk, R. C., Zeiger, R. S., Weiss, S. T., and Litonjua, A. A. (2010) Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J. Allergy Clin. Immunol. 126, 52-58.e5
21. Bikle, D. D. (2010) Vitamin D. Newly discovered actions require reconsideration of physiologic requirements. Trends Endocrinol. Metab. 21, 375-384
22. Zhang, Y., Leung, D. Y., Nordeen, S. K., and Goleva, E. (2009) Estrogen inhibits glucocorticoid action via protein phosphatase 5 (PP5)-mediated glucocorticoid receptor dephosphorylation. J. Biol. Chem. 284, 24542-24552
23. Zhang, Y., Leung, D. Y., Richers, B. N., Liu, Y., Remigio, L. K., Riches, D. W., and Goleva, E. (2012) Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J. Immunol. 188, 2127-2135
24. De Bosscher, K., Vanden Berghe, W., and Haegeman, G. (2003) The interplay between the glucocorticoid receptor and nuclear factor-κB or activator protein-1. Molecular mechanisms for gene repression. Endocr. Rev. 24, 488-522 (Pubitemid 37059110)
25. Adcock, I. M., and Caramori, G. (2001) Cross-talk between pro-inflammatory transcription factors and glucocorticoids. Immunol Cell Biol. 79, 376-384 (Pubitemid 32744283)
26. Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., and Glass, C. K. (2005) Molecular determinants of crosstalk between nuclear receptors and Toll-like receptors. Cell 122, 707-721 (Pubitemid 41242636)
27. Ito, K., Barnes, P. J., and Adcock, I. M. (2000) Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1β-induced histone H4 acetylation on lysines 8 and 12. Mol. Cell. Biol. 20, 6891-6903
28. King, E. M., Holden, N. S., Gong, W., Rider, C. F., and Newton, R. (2009) Inhibition of NF-κB-dependent transcription by MKP-1. Transcriptional repression by glucocorticoids occurring via p38 MAPK. J. Biol. Chem. 284, 26803-26815
29. Ghosh, S., and Hayden, M. S. (2008) New regulators of NF-κB in inflammation. Nat. Rev. Immunol. 8, 837-848
30. Clark, A. R., Dean, J. L., and Saklatvala, J. (2003) Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38. FEBS Lett. 546, 37-44 (Pubitemid 36782279)
31. Rosen, J., and Miner, J. N. (2005) The search for safer glucocorticoid receptor ligands. Endocr. Rev. 26, 452-464 (Pubitemid 40691300)
32. Krishnan, A. V., and Feldman, D. (2010) Molecular pathways mediating the anti-inflammatory effects of calcitriol. Implications for prostate cancer chemoprevention and treatment. Endocr. Relat. Cancer 17, R19-R38
33. Plum, L. A., and DeLuca, H. F. (2010) Vitamin D, disease and therapeutic opportunities. Nat. Rev. Drug Discov. 9, 941-955
34. 3 is a direct inducer of antimicrobial peptide gene expression. J. Immunol. 173, 2909-2912
35. Gombart, A. F., Borregaard, N., and Koeffler, H. P. (2005) Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J. 19, 1067-1077 (Pubitemid 40946432)
36. Weber, G., Heilborn, J. D., Chamorro Jimenez, C. I., Hammarsjo, A., Törmä, H., and Stahle, M. (2005) Vitamin D induces the antimicrobial protein hCAP18 in human skin. J. Invest. Dermatol. 124, 1080-1082 (Pubitemid 40629115)
37. Stio, M., Martinesi, M., Bruni, S., Treves, C., Mathieu, C., Verstuyf, A., d'Albasio, G., Bagnoli, S., and Bonanomi, A. G. (2007) The vitamin D analogue TX 527 blocks NF-κB activation in peripheral blood mononuclear cells of patients with Crohn's disease. J. Steroid Biochem. Mol. Biol. 103, 51-60 (Pubitemid 44821819)
38. Chen, P., Li, J., Barnes, J., Kokkonen, G. C., Lee, J. C., and Liu, Y. (2002) Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. J. Immunol. 169, 6408-6416 (Pubitemid 36903490)
39. Leung, D. Y., and Bloom, J. W. (2003) Update on glucocorticoid action and resistance. J. Allergy Clin. Immunol. 111, 3-22; quiz 23
40. Tobler, A., Gasson, J., Reichel, H., Norman, A. W., and Koeffler, H. P. (1987) Granulocyte-macrophage colony-stimulating factor. Sensitive and receptor-mediated regulation by 1,25-dihydroxyvitamin D3 in normal human peripheral blood lymphocytes. J. Clin. Invest. 79, 1700-1705 (Pubitemid 17117276)
41. 3 receptor. Implications for allosteric influences on nuclear receptor structure and function by a DNA element. J. Biol. Chem. 273, 10338-10348
42. 3-mediated transcriptional repression of the granulocyte-macrophage colony-stimulating factor gene. Vitamin D receptor competes for DNA binding with NFAT1 and stabilizes c-Jun. Mol. Cell. Biol. 19, 4191-4199
43. Martinez-Moczygemba, M., and Huston, D. P. (2003) Biology of common β receptor-signaling cytokines. IL-3, IL-5, and GM-CSF. J. Allergy Clin. Immunol. 112, 653-665; quiz 666
44. 3. Leuk. Res. 15, 409-418
45. Lee, J., Kim, Y., Lim, J., Kim, M., and Han, K. (2008) G-CSF and GM-CSF concentrations and receptor expression in peripheral blood leukemic cells from patients with chronic myelogenous leukemia. Ann. Clin. Lab. Sci. 38, 331-337
46. Fondell, J. D., Ge, H., and Roeder, R. G. (1996) Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. Proc. Natl. Acad. Sci. U.S.A. 93, 8329-8333 (Pubitemid 26269557)
47. Rachez, C., Lemon, B. D., Suldan, Z., Bromleigh, V., Gamble, M., Näär, A. M., Erdjument-Bromage, H., Tempst, P., and Freedman, L. P. (1999) Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature 398, 824-828
48. Chen, W., Rogatsky, I., and Garabedian, M. J. (2006) MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor. Mol. Endocrinol. 20, 560-572 (Pubitemid 43291208)
49. Hittelman, A. B., Burakov, D., Iñiguez-Lluhi, J. A., Freedman, L. P., and Garabedian, M. J. (1999) Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins. EMBO J. 18, 5380-5388 (Pubitemid 29465587)