Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages

Cellular Immunology

Volumn 280, Issue 1, 2012, Pages 36-43

  Di Rosa, M ^a   Malaguarnera, G ^a   De Gregorio, C ^a   Palumbo, M ^a   Nunnari, G ^a   Malaguarnera, L ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

1 ,25 Dihydroxyvitamin D3; Cytokines; Differentiated macrophages; Monocytes; Toll like receptors

Indexed keywords

CALCITRIOL; CD163 ANTIGEN; CD68 ANTIGEN; CHEMOKINE RECEPTOR CXCR2; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MESSENGER RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; VITAMIN D RECEPTOR;

ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL FUNCTION; CELL INFILTRATION; CELL ISOLATION; CELL MATURATION; CHEMOTAXIS; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; INNATE IMMUNITY; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANTIGENS, DIFFERENTIATION; CALCITRIOL; CELL DIFFERENTIATION; CELLS, CULTURED; CHEMOTAXIS; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; IMMUNOMODULATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MONOCYTES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84871453051     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2012.10.009     Document Type: Article

References (39)

1. 3: basic concepts. J. Ster. Biochem. Mol. Biol. 2005, 97:93-101.
2. Di Rosa M., Malaguarnera M., Nicoletti F., Malaguarnera L. Vitamin D3: a helpful immuno-modulator. Immunology 2011, 134:123-139.
3. Veldman C.M., Cantorna M.T., DeLuca H.F. Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch. Biochem. Biophys. 2000, 374:334-338.
4. Hewison M. Vitamin D and the immune system: new perspectives on an old theme. Endocrinol. Metab. Clin. North Am. 2010, 39:365-379.
5. 3 exertsopposing effects to IL-4 on MHC class-II antigen expression, accessory activity, and phagocytosis of human monocytes. Scand. J. Immunol. 1993, 38:535-540.
6. Abu-Amer Y., Bar-Shavit Z. Impaired bone marrow-derived macrophage differentiation in vitamin D deficiency. Cell. Immunol. 1993, 151:356-368.
7. 3 by normal human macrophages. Biochem. Biophys. Res. Commun. 1985, 127. 596-3.
8. 3 metabolism by lipopolysaccharide-stimulated normal human macrophages. J. Clin. Endocrinol. Metab. 1987, 64:1-9.
9. Takeuchi O., Sato S., Horiuchi T., Hoshino K., Takeda K., Dong Z., Modlin R.L., Akira S. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 2002, 169:10-14.
10. Thoma-Uszynski S., Stenger S., Takeuchi O., Ochoa M.T., Engele M., Sieling P.A., Barnes P.F., Rollinghoff M., Bolcskei P.L., Wagner M., Akira S., Norgard M.V., Belisle J.T., Godowski P.J., Bloom B.R., Modlin R.L. Induction of direct antimicrobial activity through mammalian toll-like receptors. Science 2001, 291:1544-1547.
11. 3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immunol 2006, 36:361-370.
12. Scherberich J.E., Kellermeyer M., Ried C., Hartinger A. 1-alpha-calcidol modulates major human monocyte antigens and toll-like receptors TLR 2 and TLR-4 in vitro. Eur. J. Med. Res. 2005, 10:179-182.
13. Martinez F.O., Gordon S., Locati M., Mantovani A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J. Immunol. 2006, 177:7303-7311.
14. Di Rosa M., Zambito A.M., Marsullo A.R., Li Volti G., Malaguarnera L. Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways. J. Cell. Biochem. 2009, 107:881-889.
15. Di Rosa M., Musumeci M., Scuto A., Musumeci S., Malaguarnera L. Effect of interferon-gamma, interleukin-10, lipopolysaccharide and tumor necrosis factor-alpha on chitotriosidase synthesis in human macrophages. Clin. Chem. Lab. Med. 2005, 43:499-502.
16. Boot R.G., Renkema G.H., Strijland A., van Zonneveld A.J., Aerts J.M. Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages. J. Biol. Chem. 1995, 270:26252-26256.
17. Wiggins H.L., Rappoport J.Z. An agarose spot assay for chemotactic invasion. Biotechniques 2010, 48:121-124.
18. Yang De., Chen Q., Schmidt A.P., Anderson G.M., Wang J.M., Wooters J., Oppenheim J.J., Chertov O. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J. Exp. Med. 2000, 192:1069-1074.
19. Mookherjee N., Lippert D.N., Hamill P., Falsafi R., Nijnik A., Kindrachuk J., Pistolic J., Gardy J., Miri P., Naseer M., Foster L.J., Hancock R.E. Intracellular receptor for human host defense peptide LL-37 in monocytes. J. Immunol. 2009, 183:2688-2696.
20. Zhang Z., Cherryholmes G., Chang F., Rose D.M., Schraufstatter I., Shively J.E. Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils. Eur. J. Immunol. 2009, 39:3181-3194.
21. Lee B.N., Kim T.H., Jun J.B., Yoo D.H., Woo J.H., Choi S.J., Lee Y.H., Song G.G., Kim Y., Lee J.Y., Sohn J., Ji J.D. Upregulation of interleukin-1β production by 1,25-dihydroxyvitamin D(3) in activated human macrophages. Mol. Biol. Rep. 2011, 38:2193-2201.
22. Zhang Y., Leung D.Y., Richers B.N., Liu Y., Remigio L.K., Riches D.W., Goleva E. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J. Immunol. 2012 Mar 1, 188(5):2127-2135.
23. Gambhir V., Kim J., Siddiqui S., Taylor M., Byford V., Petrof E.O., Jones G., Basta S. Influence of 1,25-dihydroxy vitamin D3 on TLR-4-induced activation of antigen presenting cells is dependent on the order of receptor engagement. Immunobiology 2011, 216:988-996.
24. Parihar A., Eubank T.D., Doseff A.I. Monocytes and macrophages regulate immunity through dynamic networks of survival and cell death. J. Innate Immun. 2010, 2:204-215.
25. Du T., Zhou Z.G., You S., et al. Regulation by 1, 25-dihydroxy-vitamin D3 on altered TLRs expression and response to ligands of monocyte from autoimmune diabetes. Clin. Chim. Acta 2009, 402:33-38.
26. Puerta-Guardo H., Medina F., Cruz Hernández S.I., Rosales V.H., Ludert J.E., del Angel R.M. The 1α,25-dihydroxy-vitamin D3 reduces dengue virus infection in human myelomonocyte (U937) and hepatic (Huh-7) cell lines and cytokine production in the infected monocytes. Antiviral Res. 2012, 94:57-61.
27. Kanzler H., Barrat F.J., Hessel E.M., Coffman R.L. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat. Med. 2007, 13:52-59.
28. Liu P.T., Schenk M., Walker V.P., Dempsey P.W., Kanchanapoomi M., Wheelwrigh M., Vazirnia A., Zhang X., Steinmeyer A., Zügel U., Hollis B.W., Cheng G., Modlin R.L. Convergence of IL-1beta and VDR activation pathways in human TLR-2/1-induced antimicrobial responses. PLoS ONE 2009, 4:e5810.
29. 3 and retinoic acid in the regulation of CD14 and CD23 expression during monocytic differentiation of U-937 cells. J. Immunol. 1993, 150:3487-3495.
30. 3 down-regulates intra-cellular Toll-like receptor 9-induced IL-6 production in human monocytes. Rheumatology (Oxford) 2010, 49:1466-1471.
31. Sochorová K., Budinský V., Rozková D., Tobiasová Z., Dusilová-Sulková S., Spísek R., Bartůnková J. Paricalcitol (19-nor-1,25-dihydroxyvitamin D2) and calcitriol (1,25-dihydroxyvitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells. Clin Immunol. 2009, 133:69-77.
32. Gao D., Trayhurn P., Bing C. 1,25-Dihydroxyvitamin D(3) inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes. Int. J. Obes. (London) 2012.
33. 2-vitamin D3 on purified mouse Langerhans cells. Cell Immunol. 2007, 245:70-79.
34. Hume D.A. Macrophages as APC and the dendritic cell myth. J. Immunol. 2008, 181:5829-5835.
35. Martinez F.O., Gordon S., Locati M., Mantovani A. Transcriptional profiling of the human monocyteto-macrophage differentiation and polarization: new molecules and patterns of gene expression. J. Immunol. 2006, 177(10):7303-7311.
36. Mosser D.M., Edwards J.P. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 2008, 8:958-969.
37. Biswas S.K., Sica A., Lewis C.E. Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms. J. Immunol. 2008, 180:2011-2017.
38. Martinez F.O., Helming L., Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu. Rev. Immunol. 2009, 27:451-483.
39. Cacopardo B., Camma C., Petta S., Pinzone M.R., Cappellani A., Zanghi A., Nicolosi A., Nunnari G. Diagnostic and therapeutical role of vitamin D in chronic hepatitis C virus infection. Front. Biosci. 2012, 4:1276-1286.