Role of vitamin D in the development of insulin resistance and type 2 diabetes

Current Diabetes Reports

Volumn 13, Issue 2, 2013, Pages 261-270

  Pilz, Stefan ^a,b   Kienreich, Katharina ^b   Rutters, Femke ^a   De Jongh, Renate ^a   Van Ballegooijen, Adriana J ^c   Grübler, Martin ^b   Tomaschitz, Andreas ^b   Dekker, Jacqueline M ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Cholecalciferol; Diabetes; Glucose metabolism; Insulin resistance; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; CALCITRIOL; CALCIUM; CALCIUM CARBONATE; GLUCOSE; INSULIN; PARICALCITOL; PLACEBO; VITAMIN D;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCIUM METABOLISM; CHRONIC KIDNEY DISEASE; DIABETES MELLITUS; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DISORDERS OF CARBOHYDRATE METABOLISM; DRUG DOSE COMPARISON; GENETIC VARIABILITY; GLUCOSE METABOLISM; GLYCEMIC CONTROL; HUMAN; HYPERCALCEMIA; HYPERCALCIURIA; IMPAIRED FASTING GLUCOSE; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN RESISTANCE; LIFESTYLE MODIFICATION; LOW DRUG DOSE; MULTICENTER STUDY (TOPIC); NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OBSERVATIONAL STUDY; OSTEOMALACIA; OSTEOPOROSIS; OUTCOME ASSESSMENT; PATHOGENESIS; PATIENT COMPLIANCE; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SUN EXPOSURE; TREATMENT DURATION; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN INTAKE; VITAMIN METABOLISM; VITAMIN SUPPLEMENTATION;

EID: 84878639710     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-012-0358-4     Document Type: Article

References (102)

1. Lips P, van Schoor NM. The effect of vitamin D on bone and osteoporosis. Best Pract Res Clin Endocrinol Metab. 2011;25:585-91.
2. Badenhoop K, Kahles H, Penna-Martinez M. vitamin d, immune tolerance, and prevention of Type 1 Diabetes. Curr Diab Rep. (in press).
3. Thomas GN, Scragg R, Jiang CQ, et al. Hyperglycaemia and vitamin D: A systematic overview. Curr Diabetes Rev. 2012;8:18-31.
4. Muscogiuri G, Sorice GP, Ajjan R, et al. Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives. Nutr Metab Cardiovasc Dis. 2012;22:81-7.
5. Holick MF. Diabetes and vitamin D connection. Curr Diab Rep. 2008;8:393-8.
6. Li YC. Vitamin DF, and diabetic nephropathy. Curr Diab Rep. 2008;8:464-9.
7. Bouillon R, Carmeliet G, Verlinden L, et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev. 2008;29:726-76.
8. Pilz S, Tomaschitz A, März W, et al. Vitamin D, cardiovascular disease and mortality. Clin Endocrinol. 2011;75:575-84.
9. Pilz S, Tomaschitz A, Drechsler C, et al. Vitamin D supplementation: A promising approach for the prevention and treatment of strokes. Curr Drug Targets. 2011;12:88-96.
10. Souberbielle JC, Body JJ, Lappe JM, et al. Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity, and cancer: recommendations for clinical practice. Autoimmun Rev. 2010;9:709-15.
11. Pilz S, Tomaschitz A, Drechsler C, et al. Vitamin D deficiency and myocardial diseases. Mol Nutr Food Res. 2010;54:1103-13.
12. • Kupferschmidt K. Uncertain verdict as vitamin D goes on trial. Science. 2012;337:1476-8. This article aims to summarize current controversial views on vitamin D and gives an overview on large ongoing vitamin D trials.
13. Macdonald HM, Mavroeidi A, Fraser WD, et al. Sunlight and dietary contributions to the seasonal vitamin D status of cohorts of healthy postmenopausal women living at northerly latitudes: A major cause for concern? Osteoporos Int. 2011;22:2461-72.
14. Lips P. Worldwide status of vitamin D nutrition. J Steroid Biochem Mol Biol. 2010;121:297-300.
15. Autier P, Gandini S, Mullie P. A systematic review: influence of vitamin D supplementation on serum 25-hydroxyvitamin D concentration. J Clin Endocrinol Metab. 2012;97:2606-13.
16. Tripkovic L, Lambert H, Hart K, et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: A systematic review and meta-Analysis. Am J Clin Nutr. 2012;95:1357-64.
17. Holick MF. Vitamin D, status: measurement, interpretation, and clinical application. Ann Epidemiol. 2009;19:73-8.
18. Peterlik M, Cross HS. Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology. Eur J Clin Nutr. 2009;63:1377-86.
19. Wang TJ, Zhang F, Richards JB, et al. Common genetic determinants of vitamin D insufficiency: A genome-wide association study. Lancet. 2010;376:180-8.
20. Takiishi T, Gysemans C, Bouillon R, Mathieu C. Vitamin D and diabetes. Endocrinol Metab Clin North Am. 2010;39:419-46.
21. Alvarez JA, Ashraf A. Role of vitamin d in insulin secretion and insulin sensitivity for glucose homeostasis. Int J Endocrinol. 2010;2010:351385.
22. Jorde R, Schirmer H, Wilsgaard T, et al. Polymorphisms related to the serum 25-hydroxyvitamin D level and risk of myocardial infarction, diabetes, cancer and mortality. The Tromsø Study. PLoS One. 2012;7:e37295.
23. Wolden-Kirk H, Overbergh L, Christesen HT, et al. Vitamin D and diabetes: its importance for beta cell and immune function. Mol Cell Endocrinol. 2011;347:106-20.
24. Norman AW, Frankel JB, Heldt AM, Grodsky GM. Vitamin D deficiency inhibits pancreatic secretion of insulin. Science. 1980;209:823-5.
25. Bourlon PM, Billaudel B, Faure-Dussert A. Influence of vitamin D3 deficiency and 1,25 dihydroxyvitamin D3 on de novo insulin biosynthesis in the islets of the rat endocrine pancreas. J Endocrinol. 1999;160:87-95.
26. Kajikawa M, Ishida H, Fujimoto S, et al. An insulinotropic effect of vitamin D analog with increasing intracellular Ca2+ concentration in pancreatic beta-cells through nongenomic signal transduction. Endocrinology. 1999;140:4706-12.
27. Sung CC, Liao MT, Lu KC, Wu CC. Role of vitamin d in insulin resistance. J Biomed Biotechnol. 2012;2012:634195.
28. Cheng Q, Li YC, Boucher BJ, Leung PS. A novel role for vitamin D: modulation of expression and function of the local renin-Angiotensin system in mouse pancreatic islets. Diabetologia. 2011;54:2077-81.
29. Dirks-Naylor AJ, Lennon-Edwards S. The effects of vitamin D on skeletal muscle function and cellular signaling. J Steroid Biochem Mol Biol. 2011;125:159-68.
30. Chang E, Donkin SS, Teegarden D. Parathyroid hormone suppresses insulin signaling in adipocytes. Mol Cell Endocrinol. 2009;307:77-82.
31. Bellia A, Marinoni G, D'Adamo M, et al. Parathyroid hormone and insulin resistance in distinct phenotypes of severe obesity: A cross-sectional analysis in middle-Aged men and premenopausal women. J Clin Endocrinol Metab. (in press).
32. Wu YY, Yu T, Zhang XH, et al. 1,25(OH)2D3 inhibits the deleterious effects induced by high glucose on osteoblasts through undercarboxylated osteocalcin and insulin signaling. J Steroid Biochem Mol Biol. 2012;132:112-9.
33. Prietl B, Pilz S, Wolf M, et al. Vitamin D supplementation and regulatory T cells in apparently healthy subjects: vitamin D treatment for autoimmune diseases? Isr Med Assoc J. 2010;12:136-9.
34. Giulietti A, van Etten E, Overbergh L, et al. Monocytes from type 2 diabetic patients have a pro-inflammatory profile. 1,25-Dihydroxyvitamin D(3) works as anti-inflammatory. Diabetes Res Clin Pract. 2007;77:47-57.
35. Geldmeyer-Hilt K, Heine G, Hartmann B, et al. 1,25-dihydroxyvitamin D3 impairs NF-κB activation in human naïve B cells. Biochem Biophys Res Commun. 2011;407:699-702.
36. Lindqvist PG, Olsson H, Landin-Olsson M. Are active sun exposure habits related to lowering risk of type 2 diabetes mellitus in women, a prospective cohort study? Diabetes Res Clin Pract. 2010;90:109-14.
37. Ishii H, Suzuki H, Baba T, et al. Seasonal variation of glycemic control in type 2 diabetic patients. Diabetes Care. 2001;24:1503.
38. Pittas AG, Dawson-Hughes B, Li T, et al. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care. 2006;29:650-6.
39. Liu S, Song Y, Ford ES, et al. Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-Aged and older U.S. women. Diabetes Care. 2005;28:2926-32.
40. Fung GJ, Steffen LM, Zhou X, et al. Vitamin D intake is inversely related to risk of developing metabolic syndrome in African American and white men and women over 20 y: the Coronary Artery Risk Development in Young Adults study. Am J Clin Nutr. 2012;96:24-9.
41. Maki KC, Fulgoni III VL, Keast DR, et al. Vitamin d intake and status are associated with lower prevalence of metabolic syndrome in U.S. Adults: national health and nutrition examination surveys 2003-2006. Metab Syndr Relat Disord. 2012;10:363-72.
42. • Forouhi NG, Ye Z, Rickard AP, et al. Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-Analysis of prospective studies. Diabetologia. 2012;55:2173-82. This paper highlights in 2 original studies and a meta-Analysis that low 25-hydroxyvitamin D levels are a risk factor for incident diabetes.
43. Pittas AG, Nelson J, Mitri J, et al. Plasma 25-hydroxyvitamin D and progression to diabetes in patients at risk for diabetes: An ancillary analysis in the Diabetes Prevention Program. Diabetes Care. 2012;35:565-73.
44. Hartaigh B, Thomas GN, Silbernagel G, et al. Association of 25-hydroxyvitamin D with type 2 diabetes among patients undergoing coronary angiography: cross-sectional findings from the LUdwigshafen RIsk and Cardiovascular Health (LURIC) Study. Clin Endocrinol. (in press).
45. Kabadi SM, Lee BK, Liu L. Joint Effects of obesity and vitamin D insufficiency on insulin resistance and Type 2 Diabetes: results from the NHANES 2001-2006. Diabetes Care. 2012;35:2048-54.
46. Pilz S, van den Hurk K, Nijpels G, et al. Vitamin D status, incident diabetes and prospective changes in glucose metabolism in older subjects: the Hoorn study. Nutr Metab Cardiovasc Dis. 2012;22:883-9.
47. Forouhi NG, Luan J, Cooper A, Boucher BJ, Wareham NJ. Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes. 2008;57:2619-25.
48. Kayaniyil S, Retnakaran R, Harris SB, et al. Prospective associations of vitamin D with β-cell function and glycaemia: the PROspective metabolism and ISlet cell Evaluation (PROMISE) cohort study. Diabetes. 2011;60:2947-53.
49. Gulseth HL, Gjelstad IM, Tierney AC, et al. Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome. Diabetes Care. 2010;33:923-5.
50. Earthman CP, Beckman LM, Masodkar K, Sibley SD. The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications. Int J Obes. 2012;36:387-96.
51. Annuzzi G, Della Pepa G, Vetrani C. Vitamin D and cardiovascular disease: is there evidence to support the bandwagon? Curr Atheroscler Rep. (in press).
52. • George PS, Pearson ER, Witham MD. Effect of vitamin D supplementation on glycaemic control and insulin resistance: A systematic review and meta-Analysis. Diabet Med. 2012;29:e142-50. Important recent meta-Analysis on randomized controlled trials addressing the effect of vitamin D supplementation on glycemic outcomes and incident diabetes.
53. • Mitri J, Muraru MD, Pittas AG. Vitamin D and type 2 diabetes: A systematic review. Eur J Clin Nutr. 2011;65:1005-15. Important recent meta-Analysis on observational studies and randomized controlled trials addressing the effect of vitamin D on glycemic outcomes and incident diabetes.
54. Jorde R, Figenschau Y. Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels. Eur J Nutr. 2009;48:349-54.
55. Zittermann A, Frisch S, Berthold HK, et al. Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am J Clin Nutr. 2009;89:1321-7.
56. Nilas L, Christiansen C. Treatment with vitamin D or its analogues does not change body weight or blood glucose level in postmenopausal women. Int J Obes. 1984;8:407-11.
57. Ljunghall S, Lind L, Lithell H, et al. Treatment with one-Alpha-hydroxycholecalciferol in middle-Aged men with impaired glucose tolerance-A prospective randomized double-blind study. Acta Med Scand. 1987;222:361-7.
58. Orwoll E, Riddle M, Prince M. Effects of vitamin D on insulin and glucagon secretion in non-insulin-dependent diabetes mellitus. Am J Clin Nutr. 1994;59:1083-7.
59. Fliser D, Stefanski A, Franek E, et al. No effect of calcitriol on insulin-mediated glucose uptake in healthy subjects. Eur J Clin Invest. 1997;27:629-33.
60. Major GC, Alarie F, Doré J, et al. Supplementation with calcium + vitamin D enhances the beneficial effect of weight loss on plasma lipid and lipoprotein concentrations. Am J Clin Nutr. 2007;85:54-9.
61. Pittas AG, Harris SS, Stark PC, Dawson-Hughes B. The effects of calcium and vitamin D supplementation on blood glucose and markers of inflammation in nondiabetic adults. Diabetes Care. 2007;30:980-6.
62. Sugden JA, Davies JI, Witham MD, et al. Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels. Diabet Med. 2008;25:320-5.
63. de Boer IH, Tinker LF, Connelly S, et al. Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women's Health Initiative. Diabetes Care. 2008;31:701-7.
64. Avenell A, Cook JA, MacLennan GS, et al. Vitamin D supplementation and type 2 diabetes: A substudy of a randomized placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438). Age Ageing. 2009;38:606-9.
65. Li X, Liao L, Yan X, et al. Protective effects of 1-Alpha-hydroxyvitamin D3 on residual beta-cell function in patients with adult-onset latent autoimmune diabetes (LADA). Diabetes Metab Res Rev. 2009;25:411-6.
66. Jorde R, Sneve M, Torjesen P, Figenschau Y. No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year. J Intern Med. 2010;267:462-72.
67. Nagpal J, Pande JN, Bhartia A. A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-Aged, centrally obese men. Diabet Med. 2009;26:19-27.
68. von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - A randomized, placebo-controlled trial. Br J Nutr. 2010;103:549-55.
69. Witham MD, Dove FJ, Dryburgh M, et al. The effect of different doses of vitamin D(3) on markers of vascular health in patients with type 2 diabetes: A randomized controlled trial. Diabetologia. 2010;53:2112-9.
70. de Zeeuw D, Agarwal R, Amdahl M, et al. Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): A randomized controlled trial. Lancet. 2010;376:1543-51.
71. Bock G, Prietl B, Mader JK, et al. The effect of vitamin D supplementation on peripheral regulatory T cells and β cell function in healthy humans: A randomized controlled trial. Diabetes Metab Res Rev. 2011;27:942-5.
72. Grimnes G, Figenschau Y, Almås B, Jorde R. Vitamin D, insulin secretion, sensitivity, and lipids: results from a case-control study and a randomized controlled trial using hyperglycemic clamp technique. Diabetes. 2011;60:2748-57.
73. Gepner AD, Ramamurthy R, Krueger DC, et al. A prospective randomized controlled trial of the effects of vitamin D supplementation on cardiovascular disease risk. PLoS One. 2012;7:e36617.
74. Wood AD, Secombes KR, Thies F, et al. Vitamin D3 Supplementation has no effect on conventional cardiovascular risk factors. A parallel-group, double-blind, placebo-controlled RCT. J Clin Endocrinol Metab. (in press).
75. Muldowney S, Lucey AJ, Hill TR, et al. Incremental cholecalciferol supplementation up to 15 μg/d throughout winter at 51-55 N has no effect on biomarkers of cardiovascular risk in healthy young and older adults. J Nutr. 2012;142:1519-25.
76. Harris SS, Pittas AG, Palermo NJ. A randomized, placebo-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African Americans. Diabetes Obes Metab. 2012;14:789-94.
77. • Davidson MB, Duran P, Lee ML, Friedman TC. High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D. Diabetes Care. (in press). This randomized controlled trial in a well selected cohort of prediabetic vitamin D deficient patients shows that a high dose vitamin D supplementation does not impact on glucose metabolism or incident diabetes.
78. Ardabili HR, Gargari BP, Farzadi L. Vitamin D supplementation has no effect on insulin resistance assessment in women with polycystic ovary syndrome and vitamin D deficiency. Nutr Res. 2012;32:195-201.
79. Beilfuss J, Berg V, Sneve M, et al. Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-Alpha and insulin resistance in overweight and obese subjects. Cytokine. (in press).
80. Carrillo AE, Flynn MG, Pinkston C, et al. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Clin Nutr. (in press).
81. de Boer IH, Sachs M, Hoofnagle AN, et al. Paricalcitol does not improve glucose metabolism in patients with stage 3-4 chronic kidney disease. Kidney Int. In press.
82. Petchey WG, Hickman IJ, Prins JB, et al. Vitamin D does not improve the metabolic health of patients with Chronic Kidney Disease stage 3-4: A randomized controlled trial. Nephrology. (in press).
83. Longenecker CT, Hileman CO, Carman TL, et al. Vitamin D supplementation and endothelial function in vitamin D deficient HIV-infected patients: A randomized placebo-controlled trial. Antivir Ther. 2012;17:613-21.
84. Mitri J, Dawson-Hughes B, Hu FB, Pittas AG. Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial. Am J Clin Nutr. 2011;94:486-94.
85. Nikooyeh B, Neyestani TR, Farvid M, et al. Daily consumption of vitamin D- or vitamin D + calcium-fortified yogurt drink improved glycemic control in patients with type 2 diabetes: A randomized clinical trial. Am J Clin Nutr. 2011;93:764-71.
86. Shab-Bidar S, Neyestani TR, Djazayery A, et al. Improvement of vitamin D status resulted in amelioration of biomarkers of systemic inflammation in the subjects with type 2 diabetes. Diabetes Metab Res Rev. 2012;28:424-30.
87. Shab-Bidar S, Neyestani TR, Djazayery A, et al. Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: A randomized double-blind clinical trial. BMC Med. 2011;9:125.
88. Mozaffari-Khosravi H, Hosseinzadeh-Shamsi-Anar M, et al. Effects of a single post-partum injection of a high dose of vitamin D on glucose tolerance and insulin resistance in mothers with first-time gestational diabetes mellitus. Diabet Med. 2012;29:36-42.
89. Eftekhari MH, Akbarzadeh M, Dabbaghmanesh MH, Hasanzadeh J. Impact of treatment with oral calcitriol on glucose indices in type 2 diabetes mellitus patients. Asia Pac J Clin Nutr. 2011;20:521-6.
90. Wehr E, Pilz S, Schweighofer N, et al. Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol. 2009;161:575-82.
91. Lips P. Interaction between vitamin D and calcium. Scand J Clin Lab Invest Suppl. 2012;243:60-4.
92. Soares MJ, Murhadi LL, Kurpad AV, et al. Mechanistic roles for calcium and vitamin D in the regulation of body weight. Obes Rev. 2012;13:592-605.
93. Wagner CL, Greer FR. American Academy of Pediatrics Section on Breastfeeding; American Academy of Pediatrics Committee on Nutrition. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008;122:1142-52.
94. Bischoff-Ferrari HA, Willett WC, Orav EJ, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med. 2012;367:40-9.
95. Hamann C, Kirschner S, Günther KP, Hofbauer LC. Bone, sweet bone-osteoporotic fractures in diabetes mellitus. Nat Rev Endocrinol. 2012;8:297-305.
96. Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group. KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl. 2009;113:S1-130.
97. Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011;96:53-8.
98. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911-30.
99. • Bjelakovic G, Gluud LL, Nikolova D, et al. Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev. 2011;7:CD007470. A Cochrane meta-Analysis of randomized controlled trials reporting that vitamin D3 supplementation reduces mortality significantly.
100. Pilz S, Iodice S, Zittermann A, et al. Vitamin D status and mortality risk in CKD: A meta-Analysis of prospective studies. Am J Kidney Dis. 2011;58:374-82.
101. Zittermann A, Iodice S, Pilz S, et al. Vitamin D deficiency and mortality risk in the general population: A meta-Analysis of prospective cohort studies. Am J Clin Nutr. 2012;95:91-100.
102. Bischoff-Ferrari HA, Giovannucci E, Willett WC, et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 2006;84:18-28.