Synthesis and biological evaluation of novel gigantol derivatives as potential agents in prevention of diabetic cataract

PLoS ONE

Volumn 10, Issue 10, 2015, Pages

  Wu, Jie ^a   Lu, Chuanjun ^b,c   Li, Xue ^a   Fang, Hua ^a   Wan, Wencheng ^a   Yang, Qiaohong ^a   Sun, Xiaosheng ^a   Wang, Meiling ^a   Hu, Xiaohong ^a   Chen, C Y Oliver ^d   Wei, Xiaoyong ^a,d  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^b ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^c SUN YAT SEN UNIVERSITY   (China)

^d TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (BENZYLOXY) 2 [4 (BENZYLOXY) 3 METHOXYSTYRYL] 4 CHLOROBENZENE; 1 (BENZYLOXY) 4 (3,5 DIMETHOXYSTYRYL) 2 METHOXYBENZENE; 1 [3 (4 FLUOROPHENYL)PROPYL] 3,5 DIMETHOXYBENZENE; 1,2 BIS(3,5 DIMETHOXYPHENYL)ETHANE; 2 (BENZYLOXY) 1 [4 (BENZYLOXY) 3 METHOXYSTYRYL] 3 METHOXYBENZENE; 2 (BENZYLOXY) 5 [4 (BENZYLOXY) 3 METHOXYSTYRYL] 1,3 DIMETHOXYBENZEN; 2 [(BENZO[D]THIAZOL 2 YLAMINO)METHYL] 5 METHOXYPHENOL; 3 (3,5 DIMETHOXYPHENYL) 1 (4 FLUOROPHENYL)PROP 2 EN 1 ONE; 3 HYDROXY 5 METHOXYBENZALDEHYDE; 3 METHOXY 5 [(4 METHOXYPHENYLAMINO)METHYL]PHENOL; 3 METHOXY 5 [2 (NAPHTHALEN 1 YL)ETHYL]PHENOL; 4 (2 HYDROXY 3 METHOXYPHENETHYL) 2 METHOXYPHENOL; 4 (3,5 DIMETHOXYPHENETHYL) 2 METHOXYPHENOL; 4 (4 HYDROXY 3 METHOXYPHENETHYL) 2,6 DIMETHOXYPHENOL; 4 (4 HYDROXY 3 METHOXYPHENETHYL)BENZENE 1,2 DIOL; 4 CHLORO 2 (4 HYDROXY 3 METHOXYPHENETHYL)PHENOL; 4 [(3,4 DIMETHOXYPHENYLAMINO)METHYL]PHENOL; 5 [3 (4 FLUOROPHENYL)PROPYL]BENZENE 1,3 DIOL; 5,5' (ETHANE 1,2 DIYL)DIBENZENE 1,3 DIOL 5,5' (ETHANE 1,2 DIYL)DIBENZENE 1,3 DIOL; ALDEHYDE REDUCTASE; GALACTOSE; GIGANTOL; GIGANTOL DERIVATIVE; INDUCIBLE NITRIC OXIDE SYNTHASE; N (3,4 DIMETHOXYPHENETHYL) 2 (4 HYDROXYPHENYL)ACETAMIDE; N (4 HYDROXYPHENYL) 4 METHYLBENZENESULFONAMIDE; NATURAL PRODUCT; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; BIBENZYL DERIVATIVE; ENZYME INHIBITOR; GUAIACOL;

APOPTOSIS; ARTICLE; CATARACT; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC50; LENS EPITHELIUM CELL; MASS SPECTROMETRY; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DIABETES COMPLICATIONS; DRUG EFFECTS; ENZYMOLOGY; EPITHELIUM CELL; LENS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALDEHYDE REDUCTASE; APOPTOSIS; BIBENZYLS; CATARACT; CELL SURVIVAL; CELLS, CULTURED; DIABETES COMPLICATIONS; ENZYME INHIBITORS; EPITHELIAL CELLS; GUAIACOL; HUMANS; HYPOGLYCEMIC AGENTS; LENS, CRYSTALLINE; MOLECULAR STRUCTURE; NITRIC OXIDE SYNTHASE TYPE II; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84950296643     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0141092     Document Type: Article

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