Lens aldose reductase inhibiting potential of some indigenous plants

Journal of Ethnopharmacology

Volumn 86, Issue 1, 2003, Pages 113-116

  Halder, N ^a   Joshi, S ^a   Gupta, S K ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Aldose reductase; Cataract; Diabetes; Herbal drugs; Polyol

Indexed keywords

ALDEHYDE REDUCTASE; AZADIRACHTA INDICA EXTRACT; CURCUMA LONGA EXTRACT; GALACTOSE; OCIMUM SANCTUM EXTRACT; POLYOL; WITHANIA SOMNIFERA EXTRACT;

ANIMAL TISSUE; ARTICLE; CALCULATION; CATARACT; CATARACTOGENESIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; EDEMA; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; LENS; NONHUMAN; PLANT; RAT; WATER CONTENT;

AZADIRACHTA INDICA;

EID: 0037403130     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(03)00052-7     Document Type: Article

References (17)

1. Andallu B., Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera Dunal) root. Indian Journal of Experimental Biology. 38(6):2000;607-609.
2. Arun N., Nalini N. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods for Human Nutrition. 57(1):2002;41-52.
3. Chattopadhyay R.R. Hypoglycemic effect of Ocimum sanctum leaf extract in normal and streptozotocin diabetic rats. Indian Journal of Experimental Biology. 3(11):1993;891-893.
4. Collier M., Small M. The role of the polyol pathway in diabetes mellitus. British Journal of Hospital Medicine. 45:1991;38-40.
5. Gupta S.K., Joshi S., Velpandian T.et al. An update on pharmacological prospectives for prevention and development of cataract. Indian Journal of Pharmacology. 29:1997;3-10.
6. Hayman S., Kinoshita J.H. Isolation and properties of lens aldose. Journal of Biological Chemistry. 240:1965;877-882.
7. Heynengen R.van. Formation of polyols by the lens of the rat with sugar cataract. Nature. 184:1959;194.
8. Khosla P., Bhanwra S., Singh J., Seth S., Srivastava R.K. A study of hypoglycemic effects of Azadirachta indica (Neem) in normal and alloxan diabetic rabbits. Indian Journal of Physiology and Pharmacology. 44(1):2000;69-74.
9. Kinoshita J.H. Aldose reductase in the diabetic eye. XLIII Edward Jackson Memorial Lecture. American Journal of Ophthalmology. 102(6):1986;685-692.
10. Kubo E., Miyoshi N., Fukuda M., Akagi Y. Cataract formation through the polyol pathway is associated with free radical production. Experimental Eye Research. 68:1999;457-464.
11. Lee A.Y.W., Chung S.S.M. Contributions of polyol pathway to oxidative stress in diabetic cataract. Federation of American Societies for Experimental Biology. 13:1999;23-30.
12. Lim S.S., Jung S.H., Ji J., Shin K.H., Keum S.R. Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin induced diabetic rat tissues. The Journal of Pharmacy and Pharmacology. 53:2001;653-668.
13. Lowry O.H., Rosebrough N.J., Farr A.I.et al. Protein measurements with the folin phenol reagent. Journal of Biological Chemistry. 193:1951;265-275.
14. Matsuda H., Murakani T., Yashiro K., Yamahara J., Yoshikawa M. Antidiabetic principles of natural medicines. IV. Aldose reductase and alpha-glucosidase inhibitors from the roots of Salacia oblonga Wall (celastraceae): structure of a new friedelane-type triterpene, kotalagenin 16-acetate. Chemical and Pharmaceutical Bulletin. 47(12):1999;1725-1729.
15. Tomlinson D.R., Stevens E.J., Diemel L.T. Aldose reductase inhibitors and their potential for the treatment of diabetes complications. Trends in Pharmacological Science. 15:1994;292-298.
16. West C.D., Rapoport S. Colorimetric method for the estimation of dulcitol. Proceedings of the Social and Experimental Biology. 70:1949;142-145.
17. Zhang J.Q., Zhou Y.P. Inhibition of aldose reductase from rat lens by some Chinese herbs and their components. Zhongguo Zhong Yao Za Zhi. 14(9):1989;557-559.