Pyrido[1,2-a]pyrimidin-4-one derivatives as a novel class of selective aldose reductase inhibitors exhibiting antioxidant activity

Journal of Medicinal Chemistry

Volumn 50, Issue 20, 2007, Pages 4917-4927

  La Motta, Concettina La ^a   Sartini, Stefania ^a   Mugnaini, Laura ^a   Simorini, Francesca ^a   Taliani, Sabrina ^a   Salerno, Silvia ^a   Marini, Anna Maria ^a   Da Settimo, Federico ^a   Lavecchia, Antonio ^b   Novellino, Ettore ^b   Cantore, Miriam ^c   Failli, Paola ^c   Ciuffi, Mario ^c  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 PHENYLPYRIDO[1,2 A]PYRIMIDIN 4 ONE DERIVATIVE; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; ALPHA TOCOPHEROL; ANTIOXIDANT; CATECHOL; CATECHOL DERIVATIVE; DEFEROXAMINE; HYDROXYL GROUP; PHENOL; PYRIDO[1,2 A]PYRIMIDINE DERIVATIVE; TOLRESTAT; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION;

ALDEHYDE REDUCTASE; ANIMALS; ANTIOXIDANTS; BINDING SITES; CATECHOLS; HUMANS; KIDNEY; LENS, CRYSTALLINE; MODELS, MOLECULAR; PYRIDINES; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE EXTRACTS;

EID: 34948815084     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070398a     Document Type: Article

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