Inhibition of neuronal nitric oxide synthase by 4-amino pteridine derivatives: Structure-activity relationship of antagonists of (6R)-5,6,7,8- tetrahydrobiopterin cofactor

Journal of Medicinal Chemistry

Volumn 42, Issue 20, 1999, Pages 4108-4121

  Fröhlich, Lothar G ^a   Kotsonis, Peter ^a   Traub, Hermann ^c   Taghavi Moghadam, Shahriyar ^c   Al Masoudi, Najim ^c   Hofmann, Heinrich ^a   Strobel, Hartmut ^b   Matter, Hans ^b   Pfleiderer, Wolfgang ^c   Schmidt, Harald H H W ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b SANOFI   (France)

^c UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPTERIDINE DERIVATIVE; ARGININE; CITRULLINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CEREBELLUM; CHEMICAL MODIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STRUCTURE ACTIVITY RELATION; SWINE;

ANIMALS; BIOPTERIN; ENZYME INHIBITORS; ISOENZYMES; NEURONS; NITRIC OXIDE SYNTHASE; PTERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0038210982     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm981129a     Document Type: Article

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