Synthesis and in vitro evaluation of botryllazine B analogues as a new class of inhibitor against human aldose reductase

Tetrahedron

Volumn 65, Issue 15, 2009, Pages 3019-3026

  Saito, Ryota ^a   Tokita, Mai ^a   Uda, Keisuke ^a   Ishikawa, Chikako ^a   Satoh, Mitsutoshi ^a  

^a TOHO UNIVERSITY   (Japan)

Author keywords

Mixed competitive uncompetitive inhibition; Pyrazine; Reductase inhibitor

Indexed keywords

(4 HYDROXYPHENYL)PYRAZINE; (4 METHOXYPHENYL)PYRAZIN; 2 (4 HYDROXYPHENYL)CARBONYL 6 PHENYLPYRAZINE; 2 (4 METHOXYPHENYL)CARBONYL 6 PHENYLPYRAZINE; 2 BENZOYL 6 (4 HYDROXYPHENYL)PYRAZINE; 2 BENZOYL 6 (4 METHOXYPHENYL)PYRAZINE; 6 (3 HYDROXYPHENYL) 2 (4 HYDROXYPHENYL)CARBONYLPYRAZINE; 6 (3 HYDROXYPHENYL) 2 (4 METHOXYPHENYL)CARBONYLPYRAZINE; 6 (3,4 DIHYDROXYPHENYL) 2 (4 HYDROXYPHENYL) CARBONYLPYRAZINE; 6 (3,4 DIMETHOXYPHENYL) 2 (4 METHOXYPHENYL) CARBONYLPYRAZINE; 6 (4 ACETOXYPHENYL) 2 (4 ACETOXYPHENYL)CARBONYLPYRAZINE; 6 (4 ACETOXYPHENYL) 2 (4 METHOXYPHENYL)CARBONYLPYRAZINE; 6 (4 AMINOPHENYL) 2 (4 HYDROXYPHENYL)CARBONYLPYRAZINE; 6 (4 AMINOPHENYL) 2 (4 METHOXYPHENYL)CARBONYLPYRAZINE; 6 (4 BIPHENYLYL) 2 (4 HYDROXYPHENYL)CARBONYLPYRAZINE; 6 (4 BIPHENYLYL) 2 (4 METHOXYPHENYL)CARBONYLPYRAZINE; 6 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL)CARBONYLPYRAZINE; 6 (4 FLUOROPHENYL) 2 (4 METHOXYPHENYL)CARBONYLPYRAZINE; 6 (4 HYDROXYPHENYL) 2 (4 METHOXYPHENYL)CARBONYLPYRAZINE; 6 (4 MERCAPTOPHENYL) 2 (4 HYDROXYPHENYL) CARBONYLPYRAZINE; 6 (4 MERCAPTOPHENYL) 2 (4 METHOXYPHENYL) CARBONYLPYRAZINE; 6 BENZOYL 2 CHLOROPYRAZINE; ALDOSE REDUCTASE INHIBITOR; BOTRYLLAZINE B; BOTRYLLAZINE B DERIVATIVE; COELENTERAMIDE; EPALRESTAT; PYRAZINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SORBINIL; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME KINETICS; IC 50; IN VITRO STUDY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SUZUKI REACTION;

EID: 61549136115     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2009.01.020     Document Type: Article

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