Design, synthesis, and evaluation of resveratrol derivatives as Aß1-42 aggregation inhibitors, antioxidants, and neuroprotective agents

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 24, 2012, Pages 7683-7687

  Lu, Chuanjun ^a   Guo, Yueyan ^a   Li, Jianheng ^a   Yao, Meicun ^a   Liao, Qiongfeng ^b   Xie, Zhiyong ^a   Li, Xingshu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

A aggregation; Alzheimer's disease; Antioxidant; Neuroprotective; Resveratrol derivatives

Indexed keywords

5 [4 (ISOPROPYLAMINO)STYRYL]BENZENE 1,3 DIOL; AMYLOID BETA PROTEIN[1-42]; ANTIOXIDANT; ANTITHROMBOCYTIC AGENT; NEUROPROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; RESVERATROL; THIOFLAVINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; FLUORESCENCE ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANTIOXIDANTS; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; REACTIVE OXYGEN SPECIES; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84870239876     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.09.105     Document Type: Article

References (23)

1. J. Pahnke, L.C. Walker, K. Scheffler, and M. Krohn Neurosci. Biobehav. Rev. 1099 2009 33
2. E.D. Roberson, and L. Mucke Science 314 2006 781
3. P. Williams, A. Sorribas, and M.-J.R. Howes Nat. Prod. Rep. 28 2011 48
4. Y. Schott, M. Decker, H. Rommelspacher, and J. Lehmann Bioorg. Med. Chem. Lett. 16 2006 5840
5. A. Wieckowska, M. Bajda, N. Guzior, and B. Malawska Eur. J. Med. Chem. 45 2010 5602
6. D.J. Selkoe Nat. Med. 1060 2011 17
7. S. Treusch, S. Hamamichi, J.L. Goodman, K.E.S. Matlack, C.Y. Chung, V. Baru, J.M. Shulman, A. Parrado, B.J. Bevis, J.S. Valastyan, H. Han, M. Lindhagen-Persson, E.M. Reiman, D.A. Evans, D.A. Bennett, A. Olofsson, P.L. DeJager, R.E. Tanzi, K.A. Caldwell, G.A. Caldwell, and S. Lindquist Science 334 2011 1241
8. A. Melo, L. Monteiro, R.M.F. Lima, D.M. de Oliveira, M.D. de Cerqueira, and R.S. El-Bachá Oxid. Med. Cell Longev. 2011 2011 Article ID 467180
9. V.H. Finder J. Alzheimers Dis. 22 2010 5
10. M. Fiala, and R. Veerhuis Exp. Gerontol. 45 2010 57
11. Y. Huang, E.D. Strobel, C.Y. Ho, C.H. Reynolds, K.A. Conway, J.A. Piesvaux, D.E. Brenneman, G.J. Yohrling, H. Moore Arnold, D. Rosenthal, R.S. Alexander, B.A. Tounge, M. Mercken, M. Vandermeeren, M.H. Parker, A.B. Reitz, and E.W. Baxter Bioorg. Med. Chem. Lett. 20 2010 3158
12. Z. Cai, B. Zhao, and A. Ratka Neuromolecular Med. 13 2011 223
13. S.-J. Park, F. Ahmad, A. Philp, K. Baar, T. Williams, H. Luo, H. Ke, H. Rehmann, R. Taussig, A.L. Brown, M.K. Kim, M.A. Beaven, A.B. Burgin, V. Manganiello, and J.H. Chung Cell 148 2012 421
14. T. Richard, P. Poupard, M. Nassra, Y. Papastamoulis, M.-L. Iglésias, S. Krisa, P. Waffo-Teguo, J.-M. Mérillon, and J.-P. Monti Bioorg. Med. Chem. 19 2011 3152
15. S.S. Kang, M. Cuendet, D.C. Endringer, V.L. Croy, J.M. Pezzuto, and M.A. Lipton Bioorg. Med. Chem. 1044 2009 17
16. J.A. Baur, and D.A. Sinclair Nat. Rev. Drug Disc. 5 2006 493
17. G. Ribeiro Morais, H. Vicente Miranda, I.C. Santos, I. Santos, T.F. Outeiro, and A. Paulo Bioorg. Med. Chem. 19 2011 7698
18. T. Mohamed, J.C.K. Yeung, and P.P.N. Rao Bioorg. Med. Chem. Lett. 21 2011 5881
19. C. Rivière, Y. Papastamoulis, P.-Y. Fortin, N. Delchier, S. Andriamanarivo, P. Waffo-Teguo, G.D.W.F. Kapche, H. Amira-Guebalia, J.-C. Delaunay, J.-M. Mérillon, T. Richard, and J.-P. Monti Bioorg. Med. Chem. Lett. 20 2010 3441
20. B. Ou, M. Hampsch-Woodill, and R.L. Prior J. Agric. Food Chem. 49 2001 4619
21. M. Rosini, V. Andrisano, M. Bartolini, M.L. Bolognesi, P. Hrelia, A. Minarini, A. Tarozzi, and C. Melchiorre J. Med. Chem. 48 2004 360
22. Y. Oyama, A. Hayashi, T. Ueha, and K. Maekawa Brain Res. 635 1994 113
23. J.A. Lenhart, X. Ling, R. Gandhi, T.L. Guo, P.M. Gerk, D.H. Brunzell, and S. Zhang J. Med. Chem. 53 2010 6198